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Domain > www.longevitygenomics.org
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More information on this domain is in
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DNS Resolutions
Date
IP Address
2023-06-05
3.22.62.2
(
ClassC
)
2025-11-01
3.18.152.57
(
ClassC
)
Port 80
HTTP/1.1 302 FoundContent-Type: text/html; charsetiso-8859-1Date: Sat, 01 Nov 2025 10:12:12 GMTLocation: https://www.longevitygenomics.org/Server: ApacheContent-Length: 218Connection: keep-alive !DOCTYPE HTML PUBLIC -//IETF//DTD HTML 2.0//EN>html>head>title>302 Found/title>/head>body>h1>Found/h1>p>The document has moved a hrefhttps://www.longevitygenomics.org/>here/a>./p>/body>/html>
Port 443
HTTP/1.1 200 OKCache-Control: must-revalidate, no-cache, privateContent-language: enContent-Type: text/html; charsetUTF-8Date: Sat, 01 Nov 2025 10:12:12 GMTExpires: Sun, 19 Nov 1978 05:00:00 GMTLink: http://www.longevitygenomics.org/node/20>; relcanonicalLink: http://www.longevitygenomics.org/node/20>; relshortlinkLink: http://www.longevitygenomics.org/node/20>; relrevisionServer: ApacheX-Content-Type-Options: nosniffX-Content-Type-Options: nosniffX-Drupal-Cache: HITX-Drupal-Dynamic-Cache: HITX-Frame-Options: SAMEORIGINX-Generator: Drupal 8 (https://www.drupal.org)X-UA-Compatible: IEedgeContent-Length: 13970Connection: keep-alive !DOCTYPE html>html langen dirltr prefixcontent: http://purl.org/rss/1.0/modules/content/ dc: http://purl.org/dc/terms/ foaf: http://xmlns.com/foaf/0.1/ og: http://ogp.me/ns# rdfs: http://www.w3.org/2000/01/rdf-schema# schema: http://schema.org/ sioc: http://rdfs.org/sioc/ns# sioct: http://rdfs.org/sioc/types# skos: http://www.w3.org/2004/02/skos/core# xsd: http://www.w3.org/2001/XMLSchema# > head> meta charsetutf-8 />script>(function(i,s,o,g,r,a,m){iGoogleAnalyticsObjectr;irir||function(){(ir.qir.q||).push(arguments)},ir.l1*new Date();as.createElement(o),ms.getElementsByTagName(o)0;a.async1;a.srcg;m.parentNode.insertBefore(a,m)})(window,document,script,https://www.google-analytics.com/analytics.js,ga);ga(create, UA-172719723-1, {cookieDomain:auto});ga(set, anonymizeIp, true);ga(send, pageview);/script>meta nameGenerator contentDrupal 8 (https://www.drupal.org) />meta nameMobileOptimized contentwidth />meta nameHandheldFriendly contenttrue />meta nameviewport contentwidthdevice-width, initial-scale1.0 />link relshortcut icon href/sites/default/files/girke-favicon.ico typeimage/vnd.microsoft.icon />link relcanonical hrefhttp://www.longevitygenomics.org/node/20 />link relshortlink hrefhttp://www.longevitygenomics.org/node/20 />link relrevision hrefhttp://www.longevitygenomics.org/node/20 /> title>Welcome | Longevity Genomics/title> link relstylesheet mediaall href/sites/default/files/css/css_c8uKrkdw3uTl-xXgGz0TtfMpOZq9ps2b3GoXRcXqFfo.css />link relstylesheet mediaall href/sites/default/files/css/css_5fSjyn0il64wVnYBIIQT46k7X4vvbCdbdAF6JH4d75Y.css /> !--if lte IE 8>script src/sites/default/files/js/js_VtafjXmRvoUgAzqzYTA3Wrjkx9wcWhjP0G4ZnnqRamA.js>/script>!endif--> meta nameviewport contentwidthdevice-width, initial-scale1.0, maximum-scale1.0, user-scalableno> meta nameHandheldFriendly contenttrue /> meta nameapple-touch-fullscreen contentYES /> /head> body classfront> a href#main-content classvisually-hidden focusable> Skip to main content /a> div classdialog-off-canvas-main-canvas data-off-canvas-main-canvas> div classpage classpage > a nameTop idTop>/a>header idheader classheader roleheader> div classcontainer> button typebutton classnavbar-toggle data-togglecollapse data-target#main-menu-inner> span classsr-only>Toggle navigation/span> span classicon-bar>/span> span classicon-bar>/span> span classicon-bar>/span> /button> div classregion region-header> div idblock-newlongevity2 classblock block-block-content block-block-contentb6e2aec1-345f-494f-b253-ba6e735d03df> div classclearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item>p>img altSite Header data-entity-typefile data-entity-uuid77ee967d-914a-4452-ada7-0a74d9220902 height106 src/sites/default/files/inline-images/Site_Header_0.png width622 />/p>/div> /div> /div> /div>/header> nav idmain-menu classnavbar navbar-default rolenavigation> div classcollapse navbar-collapse idmain-menu-inner> div classcontainer> div classregion region-main-menu> nav rolenavigation aria-labelledbyblock-mainnavigation-menu idblock-mainnavigation classblock block-menu navigation menu--main> h2 classvisually-hidden idblock-mainnavigation-menu>Main navigation/h2> ul classmenu> li classmenu-item> a href/ data-drupal-link-system-path<front> classis-active>Home/a> /li> li classmenu-item> a href/funding data-drupal-link-system-pathnode/24>Funding Opportunities/a> /li> li classmenu-item menu-item--expanded> a href/projects data-drupal-link-system-pathnode/3>Projects/a> ul classmenu> li classmenu-item> a href/projects data-drupal-link-system-pathnode/3>Project Overview/a> /li> li classmenu-item> a href/projects1 data-drupal-link-system-pathnode/4>LAV identification/a> /li> li classmenu-item> a href/projects2 data-drupal-link-system-pathnode/5>Functional annotation based gene prioritization/a> /li> li classmenu-item> a href/projects3 data-drupal-link-system-pathnode/6> LAG identification from gene expression or model organisms/a> /li> li classmenu-item> a href/projects4 data-drupal-link-system-pathnode/7>Genetic Instrumental Variables and Mendelian Randomization/a> /li> li classmenu-item> a href/projects5 data-drupal-link-system-pathnode/8>Longevity-Associated Drugs (LAD)/a> /li> /ul> /li> li classmenu-item> a href/downloads data-drupal-link-system-pathnode/12>Downloads/a> /li> li classmenu-item> a href/software data-drupal-link-system-pathnode/9>Tools/a> /li> li classmenu-item> a href/results data-drupal-link-system-pathnode/13>Results/a> /li> li classmenu-item> a href/members data-drupal-link-system-pathnode/19>Members/a> /li> li classmenu-item> a href/pubs data-drupal-link-system-pathnode/10>Publications/a> /li> li classmenu-item> a href/internal data-drupal-link-system-pathnode/21>Internal/a> /li> /ul> /nav>nav rolenavigation aria-labelledbyblock-useraccountmenu-2-menu idblock-useraccountmenu-2 classblock block-menu navigation menu--account> h2 classvisually-hidden idblock-useraccountmenu-2-menu>User account menu/h2> ul classmenu> li classmenu-item> a href/user/login data-drupal-link-system-pathuser/login>Log in/a> /li> /ul> /nav> /div> /div> /div> /nav> section idmain classmain rolemain> a idmain-content>/a> div classcontainer> div classrow> div classcontent col-lg-12 col-md-12 col-sm-12 col-xs-12> div classregion region-content> div data-drupal-messages-fallback classhidden>/div>div idblock-zircon-page-title classblock block-core block-page-title-block> h1 classpage-title>span propertyschema:name classfield field--name-title field--type-string field--label-hidden>Welcome/span>/h1> /div>div idblock-zircon-content classblock block-system block-system-main-block> article data-history-node-id20 rolearticle about/node/20 typeofschema:WebPage> span propertyschema:name contentWelcome classrdf-meta hidden>/span> div> div propertyschema:text classclearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item>p>You have reached the website for the a href/index.php/node/20>Longevity Genomics/a> research group, an a href/#funding>NIA funded resource-related cooperative agreement/a>. Through the navigation menu you will find pages describing our members, research projects, and open source data, tools, and resources that enable us and others to design translational strategies to promote healthy human aging based on genetic variants associated with longevity./p>h3 idproject-summary>Project Summary/h3>p>Our overall approach, as outlined in the flowchart below, is to use strong>Longevity-Associated Variants (LAVs)/strong>, gene-expression studies, and evidence from model organisms to identify strong>Longevity-Associated Genes (LAGs)/strong>. strong>Mendelian Randomization (MR)/strong> analysis will evaluate the potential impact modulating LAG activity might have on longevity, and candidate strong>Longevity-Associated Drugs (LADs)/strong> targeting LAGs will be identified. To learn more about specific projects, please click on the green icons and visit our a href/projects/>project overview/a> page./p>object data/sites/default/files/2017-10/overallFlowchart-relative-links.svg>/object>h3 idproject-goals>Project Goals/h3>ol>li>Create a research resource that is publicly available through this website to enable scientists to develop translational strategies to promote human longevity. Our publicly-available infrastructure will include the following. ul>li>strong>Software tools/strong> in the form of R packages and analysis walkthroughs in the form of vignettes that will enable researchers to adopt and extend our analytical methods./li> li>strong>Datasets/strong> used by our project. Datasets will include genome-wide single nucleotide polymorphism (SNP) association results for human age-related traits, functional human genomic annotation, information from tissue-specific expression quantitative trait locus (eQTL) studies, and datasets of chemical properties and protein targets of small molecule compounds./li> li>strong>Results/strong> generated through our research. Results will include annotated genome-wide SNP association results, genetic instrumental variables that can be used in Mendelian Randomization analysis, expression profiles associated with traits relevant to human aging, and small molecule compounds targeting genes of interest and expression profiles associated with human aging./li> li>Armed with our data resources and software tools, outside researchers will be able to reproduce our results and extend our approaches to their own datasets. For those who prefer to browse results, our results will be available as downloadable files and through web-based solutions such as a hrefhttp://shiny.rstudio.com/ target_blank>Shiny/a> and a hrefhttp://bioconductor.org/packages/release/bioc/html/ReportingTools.html target_blank>ReportingTools/a>, where appropriate./li> /ul>/li> li>Develop translational strategies to promote human longevity using our research resource. Our translational strategies are based on the identification of modifiable factors that can be pharmacologically targeted and that are causally related to healthy human aging. We organize annual in-person meetings for project members in Washington DC to discuss our analysis methods and translational strategies. Together with our Research Planning Committee, we will design pilot studies to test the feasibility of prioritized translational strategies and we will provide small funding opportunities for scientists to perform these pilot studies. Following each meeting, we will post information about our prioritized translational strategies and pilot studies on the a href/pubs>Publications/a> page of this website./li>/ol>h3 idupdates>Updates/h3>p>Users should be aware that this site is still a work in progress. Many components of this site are under heavy development./p>h3 id-funding>a namefunding idfunding>/a> Funding/h3>p>This project is funded by NIH grant U24AG051129 awarded by the National Institute on Aging (NIA)./p>ul>li>a hrefhttps://www.nia.nih.gov/research/blog/2015/12/translating-genetic-research-find-new-links-healthy-aging target_blank>Discussion by Nalini Raghavachari on NIA blog/a>/li>/ul>h3 idcontact>Contact/h3>p>Researchers interested in learning more about the Longevity Genomics project can contact Dan Evans (Daniel dot Evans at ucsf dot edu)/p>object data/sites/default/files/2017-10/images/logos/InstitutionLogos_210203.svg>/object>/div> /div>/article> /div> /div> !----> /div> /div> /div> /section> a href#Top classbtn-btt titleBack to Top styledisplay: block;>/a> /div> /div> script typeapplication/json data-drupal-selectordrupal-settings-json>{path:{baseUrl:\/,scriptPath:null,pathPrefix:,currentPath:node\/20,currentPathIsAdmin:false,isFront:true,currentLanguage:en},pluralDelimiter:\u0003,suppressDeprecationErrors:true,ajaxPageState:{libraries:classy\/base,classy\/messages,core\/html5shiv,core\/normalize,google_analytics\/google_analytics,system\/base,zircon\/global-styling,zircon\/skins-menu,theme:zircon,theme_token:null},ajaxTrustedUrl:,google_analytics:{trackOutbound:true,trackMailto:true,trackDownload:true,trackDownloadExtensions:7z|aac|arc|arj|asf|asx|avi|bin|csv|doc(x|m)?|dot(x|m)?|exe|flv|gif|gz|gzip|hqx|jar|jpe?g|js|mp(2|3|4|e?g)|mov(ie)?|msi|msp|pdf|phps|png|ppt(x|m)?|pot(x|m)?|pps(x|m)?|ppam|sld(x|m)?|thmx|qtm?|ra(m|r)?|sea|sit|tar|tgz|torrent|txt|wav|wma|wmv|wpd|xls(x|m|b)?|xlt(x|m)|xlam|xml|z|zip},user:{uid:0,permissionsHash:920557a07cbb995eb8f24dccca26b2014ff709df26f85ff8202adadce4849a7e}}/script>script src/sites/default/files/js/js_76IlHPPSMwTwOF3beTNK6vEv80C3B_grQNlMJ7dTMmI.js>/script> /body>/html>
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