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!doctype html>html langen-US>head>meta charsetUTF-8>meta http-equivX-UA-Compatible contentIEedge>meta nameviewport contentwidthdevice-width, initial-scale1.0>meta nameauthor contentJohannes Gutenberg University Mainz>meta namecopyright contentJohannes Gutenberg University Mainz>meta propertyog:site_name contentJohannes Gutenberg University Mainz>meta namerobots contentindex, follow, noarchive>link relpingback hrefhttps://fnb-idn.biologie.uni-mainz.de/xmlrpc.php>link relprofile hrefhttp://gmpg.org/xfn/11>title>Functional Neurobiology/title>link relshortcut icon href/favicon.ico>link relicon href/favicon.ico>meta namerobots contentmax-image-preview:large />	style>img:is(sizesauto i, sizes^auto, i) { contain-intrinsic-size: 3000px 1500px }/style>	link reldns-prefetch href//www.blogs.uni-mainz.de />link reldns-prefetch href//blogs-cdn.uni-mainz.de />link relstylesheet idjgu-style-css hrefhttps://blogs-cdn.uni-mainz.de/styles/jgu_style.css?ver95b742bad4079343422b3af339e265e6ac2efe16 typetext/css mediaall />link relstylesheet idtablepress-default-css hrefhttps://fnb-idn.biologie.uni-mainz.de/wp-content/plugins/tablepress/css/build/default.css?ver3.0.1 typetext/css mediaall />link relstylesheet idjgu-tablepress-css hrefhttps://blogs-cdn.uni-mainz.de/styles/jgu_style_table.css?ver00b7be3e5c8156dd4a4667a5520f0b4a1b9808b5 typetext/css mediaall />link relstylesheet idwp-block-library-css hrefhttps://fnb-idn.biologie.uni-mainz.de/wp-includes/css/dist/block-library/style.min.css?ver6.7.1 typetext/css mediaall />link relstylesheet idjgu-jogustine_styles-css hrefhttps://www.blogs.uni-mainz.de/fb10-fnb-idn/wp-content/plugins/jgu-jogustine/dist/styles/blocks/styles.css?ver1639498111 typetext/css mediaall />style idclassic-theme-styles-inline-css typetext/css>/*! 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interactions of calcium channel subunits hrefhttps://fnb-idn.biologie.uni-mainz.de/dynamic-interactions-of-calcium-channel-subunits/>Dynamic interactions of calcium channel subunits/a>/li>	li classmenueebene3off>a titleMobility of adhesion molecules within synapses hrefhttps://fnb-idn.biologie.uni-mainz.de/mobility-of-adhesion-molecules-within-synapses/>Mobility of adhesion molecules within synapses/a>/li>	li classmenueebene3off>a titleTransfer, integration and storage of information in neuronal networks hrefhttps://fnb-idn.biologie.uni-mainz.de/transfer-integration-and-storage-of-information-in-neuronal-networks/>Transfer, integration and storage of information in neuronal networks/a>/li>/ul>/li>li classmenueebene2off>a titleBachelor's and Master's projects hrefhttps://fnb-idn.biologie.uni-mainz.de/teaching/>Bachelor’s and Master’s projects/a>/li>li classmenueebene2off>a titleOpen Positions hrefhttps://fnb-idn.biologie.uni-mainz.de/open-positions/>Open Positions/a>/li>li classmenueebene2off>a titleOur Team hrefhttps://fnb-idn.biologie.uni-mainz.de/unser-team/>Our Team/a>/li>li classmenueebene2off>a titlePublications hrefhttps://fnb-idn.biologie.uni-mainz.de/publications/>Publications/a>/li>li classmenueebene2off>a titleFunding hrefhttps://fnb-idn.biologie.uni-mainz.de/funding/>Funding/a>/li>li classmenueebene2off>a titleContact hrefhttps://fnb-idn.biologie.uni-mainz.de/contact/>Contact/a>/li>/ul>!-- Navigationsbaum -->/nav>aside idspaltelinks_unten rolecomplementary>/aside>/div>article idspaltemitte classcol-sm-9 col-md-6 editorcontent>a idcontent>/a>article idpost-102 classrow row-margin post-102 page type-page status-publish hentry>h1>Research Group Functional Neurobiology/h1>div classentry-content>p>img fetchpriorityhigh decodingasync classalignnone size-full wp-image-1022 src//fnb-idn.biologie.uni-mainz.de/files/2019/09/pfp.png alt width664 height231 />/p>p>The fast communication between and within neuronal networks is based on the excitability of individual neurons and their connectivity to other neurons. In this respect, neurons can be seen as computational devices that integrate information from multiple synaptic contacts and transform this information into an output function. Within synaptic contacts, the number of signaling molecules, like presynaptic calcium channels and postsynaptic receptors, is in the order of a few tens to hundred molecules. Considering the stochastic nature of ion channel gating and the ability of integral proteins to change rapidly their position in the cell membrane, we address the question to which extent such “molecular noise” modulates the input-output relation of a particular neuron and will change neuronal network activity./p>p>Dynamics of molecules in the cell membrane of neurons is important within the nanometer range, a spatial scale that is most relevant within synapses. Here, we focus on voltage-gated calcium channels, synaptic adhesion molecules and postsynaptic ionotropic receptors. With the use of super resolution microscopy, we are able to look into synapses (200-500 nm large) and observe the motion of individual ion channels. Combining this approach with fluorescence-based functional readouts and electrophysiology, we explore the function of molecular dynamics in neuronal communication and memory formation. Interventions on the dynamics of single molecules revealed that local mobility of AMPA receptors and Casub>V/sub>2.1 channel has direct impact on the short-term plasticity of central synapses (Heine et al. 2008, Schneider et al. 2015, Heck et al. 2019)./p>p> /p>p>strong>These are our current research topics:/strong>/p>p>Calcium channel dynamics within the neuronal membrane/p>p>Mobility of adhesion molecules within synapses/p>p>Dynamic interactions of calcium channel subunits/p>p>Transfer, integration and storage of information in neuronal networks/p>/div>/article>/article>aside idspalterechts classcol-sm-9 col-sm-offset-3 col-md-3 col-md-offset-0 rolecomplementary>div idsearch-1 classjgu_widget widget_search>div classjgu_widget jgu_quicksearch>form methodget actionhttps://fnb-idn.biologie.uni-mainz.de/ idjgu_searchbox>fieldset classgroup>legend>Search in content/legend>label forjgu_searchstring>Search/label>input typetext names idjgu_searchstring classtext maxlength50 placeholderSearch required>button typesubmit classsubmit namesubmit idjgu_searchsubmit titleGo>Go/button>/fieldset>input typehidden namesearch_engine valueinternal>input typehidden namesitesearch valueuni-mainz.de>/form>/div>/div>div idtext-2 classjgu_widget widget_text>			div classtextwidget>br>strong>Institute of Developmental and Neurobiology (iDN)/strong>br>Functional Neurobiology  -  RG Heinebr>strong>Johannes Gutenberg-University Mainz/strong>br>Hanns-Dieter-Hüsch-Weg 15br>55128 Mainz, Germany/div>		/div>div idtext-4 classjgu_widget widget_text>h2 classheadlineboxneutral>Teaching/h2>			div classtextwidget>p>a hrefhttps://www.blogs.uni-mainz.de/fb10-biologie-eng/master-neuroscience/>Master Degree Neuroscience/a>/p>p> /p>/div>		/div>/aside>/main>footer idmain-footer classcontainer>div idfooter_pageinfos classcol-sm-4>span classsr-only>Additional information about this page/span>ul classlist-inline>li>dfn classsr-only>Page-Name:/dfn>Functional Neurobiology/li>li>dfn classsr-only>Last Update:/dfn>14. November 2019/li>/ul>/div>div idfooter_social classcol-sm-4>ul>/ul>/div>div idfooter_servicenav classcol-sm-4>ul classlist-inline>li>a hrefhttps://www.uni-mainz.de/en/privacy/ titlePrivacy>Privacy/a>/li>li>a hrefhttps://administration.uni-mainz.de/legal-notice/ titleLegal Notice>Legal Notice/a>/li>li>a hrefhttps://www.uni-mainz.de/en/accessibility/ titleAccessibility>Accessibility/a>/li>li>a href#page_start>To top of page/a>/li>/ul>/div>/footer>/div>script srchttps://blogs-cdn.uni-mainz.de/scripts/jgu.min.js?v23c6de6f03b61cddf1f141502326ca2f44f02f6d>/script>        !-- Piwik -->        script typetext/javascript>            var pkBaseURL  ((https:  document.location.protocol) ? https://webstats.zdv.uni-mainz.de/piwik/ : http://webstats.zdv.uni-mainz.de/piwik/);            document.write(unescape(%3Cscript src + pkBaseURL + piwik.js typetext/javascript%3E%3C/script%3E));        /script>        script typetext/javascript>            try {                var piwikTracker  Piwik.getTracker(pkBaseURL + piwik.php, 11);				// Nach Absprache mit Stabsstelle Rechtsangelegenheiten - Datenschutz                // soll der Wiedererkennungscookie nur 7 Tage lang gespeichert werden                piwikTracker.setVisitorCookieTimeout(604800);// CustomVariable um die BlogID zu speichern.                piwikTracker.setCustomVariable(1, blogid, 1484, page);                piwikTracker.trackPageView();                piwikTracker.enableLinkTracking();            } catch (err) {            }        /script>        noscript>p>img src//webstats.zdv.uni-mainz.de/piwik/piwik.php?idsite11 styleborder:0 alt>/p>        /noscript>        !-- End Piwik Tracking Code -->        script typetext/javascript srchttps://blogs-cdn.uni-mainz.de/scripts/navigation.js?ver7b9f26aa33dec6b815379c7dd579556ed8e835b4 idjgu-theme-navigation-js>/script>script typetext/javascript srchttps://blogs-cdn.uni-mainz.de/scripts/skip-link-focus-fix.js?ver5c8261dffb4f346e02aba4548c75df7c7ae0e663 idjgu-theme-skip-link-focus-fix-js>/script>/body>/html>

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