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Domain > www.lc-bio.com
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AlienVault OTX
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DNS Resolutions
Date
IP Address
2014-09-09
210.209.123.158
(
ClassC
)
2025-01-12
221.12.19.205
(
ClassC
)
Port 80
HTTP/1.1 301 Moved PermanentlyServer: nginx/1.18.0Date: Sun, 12 Jan 2025 19:05:09 GMTContent-Type: text/htmlContent-Length: 169Connection: keep-aliveLocation: https://www.lc-bio.com/ html>head>title>301 Moved Permanently/title>/head>body>center>h1>301 Moved Permanently/h1>/center>hr>center>nginx/1.18.0/center>/body>/html>
Port 443
HTTP/1.1 200 OKServer: nginx/1.18.0Date: Sun, 12 Jan 2025 19:05:10 GMTContent-Type: text/html;charsetutf-8Transfer-Encoding: chunkedConnection: keep-alivex-powered-by: Nuxt !DOCTYPE html>html langzh>head>meta charsetutf-8>title>联川生物/title>meta nametheme-color content#005ca4>meta nameviewport contentwidthdevice-width, initial-scale1>meta namekeywords content联川生物 转录调控 单细胞 Olink蛋白质组学>meta namedescription content杭州联川生物为全球各地的科研用户提供基因组、转录组、蛋白组、代谢组，以及单细胞和空间组学测序服务。>meta nameformat-detection contenttelephoneno>link relstylesheet typetext/css href/static/swiper-bundle.min.css>script src/static/swiper-bundle.min.js>/script>script srchttps://webapi.amap.com/maps?v1.4.15>/script>link relmodulepreload asscript crossorigin href/_nuxt/entry.09d0aa3c.js>link relpreload asstyle href/_nuxt/entry.0a4fa952.css>link relmodulepreload asscript crossorigin href/_nuxt/index.c909bd55.js>link relmodulepreload asscript crossorigin href/_nuxt/home.e22701ea.js>link relprefetch asscript crossorigin 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stylebackground-image:url(https://www.lc-bio.com/upload/science/2023/07/09/kjfw_06.jpg); data-v-5a3dbf4c>a href/tech-service data-v-5a3dbf4c>div classtech-info data-v-5a3dbf4c>p classtech-title data-v-5a3dbf4c>基因组学/p>p classtech-title-en data-v-5a3dbf4c>Genomics/p>/div>/a>/li>li classtech-item stylebackground-image:url(https://www.lc-bio.com/upload/science/2023/7/10/1688977333269.png); data-v-5a3dbf4c>a href/tech-service data-v-5a3dbf4c>div classtech-info data-v-5a3dbf4c>p classtech-title data-v-5a3dbf4c>多组学联合分析（开发中）/p>p classtech-title-en data-v-5a3dbf4c>/p>/div>/a>/li>!---->/ul>/section>section classnews-dy box data-v-5a3dbf4c>h3 classbox-title data-v-5a3dbf4c>新闻动态/h3>p classbox-sub-title data-v-5a3dbf4c>NEWS/p>div classbox-hr data-v-5a3dbf4c>/div>div classnews-wrapper data-v-5a3dbf4c>div classnews data-v-5a3dbf4c>div classnews-left data-v-5a3dbf4c>h2 classnews-title data-v-5a3dbf4c>科研动态/h2>ul classnews-list data-v-5a3dbf4c>!---->li classselected news-item data-v-5a3dbf4c>img classnews-list-img srchttps://www.lc-bio.com//upload/science/2023/7/12/1689126089191.png data-v-5a3dbf4c>div classnews-date data-v-5a3dbf4c>p classnews-day data-v-5a3dbf4c>12/p>p data-v-5a3dbf4c>2023-07/p>/div>div classnews-info data-v-5a3dbf4c>h4 classnews-info-title data-v-5a3dbf4c>a href/tech-service-detail?cid17&id75 data-v-5a3dbf4c>真核有参转录组测序/a>/h4>p classnews-info-desc data-v-5a3dbf4c>转录组广义上指特定细胞在某一功能状态下的所有转录产物，包括mRNA 和非编码RNA（ncRNA）。转录组研究能够从整体水平研究基因功能以及基因结构，揭示特定生物学过程以及疾病发生过程中的分子机理，目前已广泛应用于基础研究、临床诊断和药物研发、动植物育种等各个领域。/p>a classnews-more href/tech-service-detail?cid17&id75 data-v-5a3dbf4c>查看更多 >/a>/div>/li>li classnews-item data-v-5a3dbf4c>!---->div classnews-date data-v-5a3dbf4c>p classnews-day data-v-5a3dbf4c>12/p>p data-v-5a3dbf4c>2023-07/p>/div>div classnews-info data-v-5a3dbf4c>h4 classnews-info-title data-v-5a3dbf4c>a href/tech-service-detail?cid17&id76 data-v-5a3dbf4c>绝对定量转录组测序/a>/h4>p classnews-info-desc data-v-5a3dbf4c>转录组测序特指对具有编码蛋白质功能的信使RNA（mRNA）进行序列测定及分析，以获得转录本信息，发现和鉴定新基因等。根据研究物种是否具有参考基因组以及注释信息。真核有参转录组主要研究的物种需要具注释完整的参考基因组信息，并对样本中mRNA的表达量以及组间差异mRNA进行分析。/p>a classnews-more href/tech-service-detail?cid17&id76 data-v-5a3dbf4c>查看更多 >/a>/div>/li>li classnews-item data-v-5a3dbf4c>!---->div classnews-date data-v-5a3dbf4c>p classnews-day data-v-5a3dbf4c>12/p>p data-v-5a3dbf4c>2023-07/p>/div>div classnews-info data-v-5a3dbf4c>h4 classnews-info-title data-v-5a3dbf4c>a href/tech-service-detail?cid17&id77 data-v-5a3dbf4c>真核无参转录组测序/a>/h4>p classnews-info-desc data-v-5a3dbf4c>真核无参转录组适用于无参考基因组的真核生物或基因组组装注释质量不高的真核生物。前期需要对物种组织中所有表达的mRNA及转录本采用Trinity等软件进行de novo组装，产生长度最长的转录本并标记为Unigene，在Unigene的基础上使用Salmon等软件进行定量计算。/p>a classnews-more href/tech-service-detail?cid17&id77 data-v-5a3dbf4c>查看更多 >/a>/div>/li>!---->/ul>/div>div classnews-right data-v-5a3dbf4c>h2 classnews-title data-v-5a3dbf4c>新闻中心/h2>div classnews-image data-v-5a3dbf4c>a href/about-detail?index5&newsTypedetail&id313 data-v-5a3dbf4c>img 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All Rights Reserved./p>div data-v-31cf26d7>a hrefhttps://beian.miit.gov.cn/#/Integrated/recordQuery target_blank data-v-31cf26d7>浙ICP备15020535号-5/a>img src/static/beian.jpg alt浙公网安备 stylewidth:16px;height:16px;vertical-align:middle;margin-left:5px;margin-right:5px; data-v-31cf26d7>a hrefhttps://beian.mps.gov.cn/#/query/webSearch?code33019202002521 relnoreferrer target_blank data-v-31cf26d7>浙公网安备33019202002521号/a>/div>/div>/div>/footer>/div>/div>script typeapplication/json id__NUXT_DATA__ data-ssrtrue>Reactive,1,{data:2,state:641,_errors:642,serverRendered:644},{6W8l71VhzM:3,ZnpEkciXG7:458,031X7Q9U1q:498,alRqIOlioq:578,DjgZsauEtM:588,RN0rC5JpWO:590,bNQpw0TksX:592,CyGwzluQvt:594,113d650sm9:596,KQKFDPp9UK:604,o6HEvWhdsF:606,2wPHVM5snr:608,hwSMj3ZHOP:610,S2QJfaO5dT:612},{code:4,datas:5,totalCount:191},0,6,102,163,207,273,341,408,450,{id:7,createTime:8,updateTime:9,title:10,subTitle:11,categoryIndex:12,imagePath:13,remark:14,isDelete:4,dropdownNavList:15,text:10,href:101},17,2023-06-24 17:35:17,2023-07-10 14:07:05,转录调控组学,Transcriptomics,1,upload/science/2023/07/09/kjfw_01.jpg,转录组学,16,27,37,47,57,68,79,90,Reactive,17,{id:18,createTime:19,updateTime:20,title:21,categoryId:7,serviceIndex:12,imagePath:22,summary:23,releaseTime:24,status:12,categoryName:10,statusName:25,link:26},75,2023-07-12 08:56:36,2023-07-26 10:05:42,真核有参转录组测序,/upload/science/2023/7/12/1689126089191.png,转录组广义上指特定细胞在某一功能状态下的所有转录产物，包括mRNA 和非编码RNA（ncRNA）。转录组研究能够从整体水平研究基因功能以及基因结构，揭示特定生物学过程以及疾病发生过程中的分子机理，目前已广泛应用于基础研究、临床诊断和药物研发、动植物育种等各个领域。,2023-07-12 09:01:15,已发布,/tech-service-detail?cid17&id75,Reactive,28,{id:29,createTime:30,updateTime:31,title:32,categoryId:7,serviceIndex:33,imagePath:22,summary:34,releaseTime:35,status:12,categoryName:10,statusName:25,link:36},76,2023-07-12 11:10:08,2023-07-26 10:06:17,绝对定量转录组测序,2,转录组测序特指对具有编码蛋白质功能的信使RNA（mRNA）进行序列测定及分析，以获得转录本信息，发现和鉴定新基因等。根据研究物种是否具有参考基因组以及注释信息。真核有参转录组主要研究的物种需要具注释完整的参考基因组信息，并对样本中mRNA的表达量以及组间差异mRNA进行分析。,2023-07-12 11:11:31,/tech-service-detail?cid17&id76,Reactive,38,{id:39,createTime:40,updateTime:41,title:42,categoryId:7,serviceIndex:43,imagePath:22,summary:44,releaseTime:45,status:12,categoryName:10,statusName:25,link:46},77,2023-07-12 11:55:07,2023-07-26 10:07:30,真核无参转录组测序,3,真核无参转录组适用于无参考基因组的真核生物或基因组组装注释质量不高的真核生物。前期需要对物种组织中所有表达的mRNA及转录本采用Trinity等软件进行de novo组装，产生长度最长的转录本并标记为Unigene，在Unigene的基础上使用Salmon等软件进行定量计算。,2023-07-12 13:00:10,/tech-service-detail?cid17&id77,Reactive,48,{id:49,createTime:50,updateTime:51,title:52,categoryId:7,serviceIndex:53,imagePath:22,summary:54,releaseTime:55,status:12,categoryName:10,statusName:25,link:56},38,2023-07-10 01:05:47,2023-07-26 10:06:39,miRNA测序,4,miRNA是在真核生物中发现的一类内源性的具有调控功能的非编码RNA（ncRNA），其长度约为18~25nt。miRNA可在转录后水平与mRNA(靶基因)以完全匹配或不完全匹配的方式结合，引起mRNA剪切降解或是抑制mRNA翻译来调控基因的表达，进而发挥其生物学调控功能。,2023-07-10 01:09:29,/tech-service-detail?cid17&id38,Reactive,58,{id:59,createTime:60,updateTime:61,title:62,categoryId:7,serviceIndex:63,imagePath:64,summary:65,releaseTime:66,status:12,categoryName:10,statusName:25,link:67},78,2023-07-17 16:17:48,2023-07-26 10:08:06,外泌体miRNA测序,5,/upload/science/2023/7/17/1689581924579.png,外泌体（exosomes）是一种直径大约为50-150nm，具有脂质双层膜结构的微小囊泡，外泌体可由大部分细胞分泌，进入各种体液内。外泌体中包含细胞的许多成分，包括DNA、RNA、脂质、代谢物以及胞质和细胞表面蛋白。细胞生成外泌体的生理目的推测是外泌体可能从细胞中清除过量和/或不必要的成分，以维持细胞内稳态。,2023-07-17 16:20:15,/tech-service-detail?cid17&id78,Reactive,69,{id:70,createTime:71,updateTime:72,title:73,categoryId:7,serviceIndex:74,imagePath:75,summary:76,releaseTime:77,status:12,categoryName:10,statusName:25,link:78},79,2023-07-17 17:26:47,2023-07-26 10:05:18,lncRNA测序,6,/upload/science/2023/7/17/1689586075522.png,长链非编码RNA（lncRNA）是一类长度大于200 nt 的非编码RNA（ncRNA），广泛存在于各种生物体内，在表观遗传调控、细胞周期调控和细胞分化调控等众多生命活动中发挥重要作用，与动植物的生长发育，人类的疾病发生有着密切关系，也可作为疾病诊断的标志物或是重要靶点。,2023-07-17 17:28:57,/tech-service-detail?cid17&id79,Reactive,80,{id:81,createTime:82,updateTime:83,title:84,categoryId:7,serviceIndex:85,imagePath:86,summary:87,releaseTime:88,status:12,categoryName:10,statusName:25,link:89},80,2023-07-18 10:32:12,2023-07-26 10:35:24,circRNA测序,7,/upload/science/2023/7/18/1689647601786.png,随着高通量测序以及生物信息分析技术的快速发展，在不同物种中鉴定出成千上万个circRNA，其中大多数circRNA 在不同物种间具有保守性和稳定性，并且circRNA 的表达具有细胞特异性、组织特异性以及发育阶段特异性。circRNA除了常规的对miRNA竞争结合的ceRNA调控机制外，还有翻译多肽等新功能，在医学及动植物基础研究及后期转化上有着巨大的潜力。,2023-07-18 10:38:10,/tech-service-detail?cid17&id80,Reactive,91,{id:92,createTime:93,updateTime:94,title:95,categoryId:7,serviceIndex:96,imagePath:97,summary:98,releaseTime:99,status:12,categoryName:10,statusName:25,link:100},94,2024-04-11 11:53:42,2024-04-11 14:47:38,免疫组TCR_BCR测序,15,/upload/science/2024/4/11/1712807385381.png,T细胞和B细胞是适应性免疫反应中的关键细胞，它们对抗原的识别依赖于各自细胞表面的特定受体——T细胞受体（TCR）和B细胞受体（BCR）。这两种受体类型能够识别广泛的抗原，这归功于它们的高度多样性。这种多样性源于TCR和BCR基因片段的不同排列组合：对于BCR来说，它的轻链和TCR的β链包括V、D、J、C区域，而BCR的重链和TCR的α链则由V、J、C区域组成。在细胞发育过程中，这些基因片段通过重组和重排，形成多种不同的变异，从而确保了受体的多样性。,2024-04-11 13:39:33,/tech-service-detail?cid17&id94,/tech-service,{id:103,createTime:104,updateTime:105,title:106,categoryIndex:33,imagePath:107,remark:106,isDelete:4,dropdownNavList:108,text:106,href:101},18,2023-06-24 17:38:54,2024-01-31 17:05:01,单细胞,upload/science/2023/07/09/kjfw_02.jpg,109,118,126,133,143,153,Reactive,110,{id:111,createTime:112,updateTime:113,title:114,categoryId:103,serviceIndex:12,imagePath:115,summary:116,status:12,categoryName:106,statusName:25,link:117},48,2023-07-12 00:22:31,2023-07-26 09:52:58,单细胞转录组测序（10x 3）,/upload/science/2023/7/13/1689180279559.jpg, 10X Genomics平台首先利用微流控技术分选单个细胞，然后将带有barcode和引物的凝胶珠以及单个细胞包裹在油滴中；在油滴中凝胶珠溶解释放反转录oligo，细胞裂解释放mRNA，通过mRNA 末端标签扩增（3’WTA）法获得用于测序的带barcode的cDNA,/tech-service-detail?cid18&id48,Reactive,119,{id:120,createTime:112,updateTime:121,title:122,categoryId:103,serviceIndex:33,imagePath:115,summary:123,releaseTime:124,status:12,categoryName:106,statusName:25,link:125},49,2023-07-26 09:45:06,单细胞免疫组测序（10x 5）, T淋巴细胞（T cell）和B淋巴细胞（B cell）主要负责适应性免疫应答，其抗原识别主要依赖于T细胞受体（T cell recptor, TCR）和B细胞受体（B cell recptor, BCR），这两类细胞表面分子的共同特点是其多样性，可以识别多种多样的抗原分子。BCR的轻链和TCRβ链由…,2023-07-19 14:50:55,/tech-service-detail?cid18&id49,Reactive,127,{id:128,createTime:112,updateTime:129,title:130,categoryId:103,serviceIndex:43,imagePath:115,summary:131,status:12,categoryName:106,statusName:25,link:132},50,2023-07-26 09:53:56,单细胞ATAC测序,ATAC-seq（Assay for Transposase Accessible Chromatin with high-throughput sequencing，染色质易开放区域测序）是2013年由美国Stanford大学的William Greenleaf教授研发了一种全新的方法，利用DNA转座酶结合高通量测序技术，来研究染色体的可进入性。ATA…,/tech-service-detail?cid18&id50,Reactive,134,{id:135,createTime:136,updateTime:137,title:138,categoryId:103,serviceIndex:53,imagePath:139,summary:140,releaseTime:141,status:12,categoryName:106,statusName:25,link:142},83,2023-07-19 10:53:56,2023-07-26 09:07:13,单细胞核转录组测序,/upload/science/2023/7/19/1689734962614.jpg,单细胞RNA-seq(scRNA-seq)已经成为探究复杂组织中细胞类型、分子变化和细胞功能的重要手段。然而，单细胞技术要求从新鲜组织中制备单细胞悬液，获得较高的细胞活性和细胞质量，而-80度冰箱海量的冻存样本因为无法制备高质量细胞悬液而无法应用于单细胞测序，这是限制单细胞技术广泛应用的主要障碍。,2023-07-19 10:55:21,/tech-service-detail?cid18&id83,Reactive,144,{id:145,createTime:146,updateTime:147,title:148,categoryId:103,serviceIndex:63,imagePath:149,summary:150,releaseTime:151,status:12,categoryName:106,statusName:25,link:152},84,2023-07-19 11:15:41,2023-07-26 09:46:44,FFPE单细胞转录组测序,/upload/science/2023/7/19/1689736364477.jpg,FFPE单细胞测序技术是基于随机引物的单细胞全长转录组扩增技术，能够实现对RNA非完整样本的转录本进行扩增，该技术非常适用于FFPE标本的单细胞检测。由于是随机引物的扩增方式，对于物种没有限制，原则上任何物种采用FFPE保存的标本，均可以采用该方式进行单细胞转录本的检测！,2023-07-19 11:17:01,/tech-service-detail?cid18&id84,Reactive,154,{id:155,createTime:156,updateTime:157,title:158,categoryId:103,serviceIndex:74,imagePath:159,summary:160,releaseTime:161,status:12,categoryName:106,statusName:25,link:162},88,2023-07-19 13:48:45,2023-07-26 09:54:50,墨卓单细胞转录组,/upload/science/2023/7/19/1689745187192.jpg,MobiNova®高通量单细胞测序技术包含可适配真核生物的MobiNova®-100，以及适配原核生物的MobiNova®-M1两大高通量单细胞测序建库平台。,2023-07-19 13:50:08,/tech-service-detail?cid18&id88,{id:164,createTime:165,title:166,categoryIndex:43,imagePath:167,remark:166,isDelete:4,dropdownNavList:168,text:166,href:101},25,2024-01-31 17:02:44,空间组学,/upload/science/2024/1/31/1706691754817.jpg,169,178,185,196,Reactive,170,{id:171,createTime:172,updateTime:173,title:174,categoryId:164,serviceIndex:74,imagePath:175,summary:176,releaseTime:173,status:12,categoryName:166,statusName:25,link:177},92,2024-01-31 17:37:07,2024-02-04 13:44:08,Visium HD,/upload/science/2024/1/31/1706692043939.jpg,Visium HD推动了空间转录组发展的新时代，以单细胞尺度的分辨率增强了已被验证的全转录组空间信息，实现了全组织覆盖，并可通过创新的探针和Visium CytAssist技术的支持为Visium HD工作流程提供一流的数据。,/tech-service-detail?cid25&id92,Reactive,179,{id:180,createTime:112,updateTime:181,title:182,categoryId:164,serviceIndex:85,imagePath:115,summary:183,status:12,categoryName:166,statusName:25,link:184},51,2024-01-31 17:04:11,空间转录组,细胞的转录信息、空间位置信息、形态学信息、生理学信息，对理解细胞功能至关重要。空间转录组技术实现在组织环境中将基因表达情况可视化。联川空间转录组测序是利用10X Genomics Visium平台，结合显微成像、芯片、测序技术，从一片完整的冰冻组织切片,/tech-service-detail?cid25&id51,Reactive,186,{id:187,createTime:188,updateTime:189,title:190,categoryId:164,serviceIndex:191,imagePath:192,summary:193,releaseTime:194,status:12,categoryName:166,statusName:25,link:195},86,2023-07-19 11:37:09,2024-01-31 17:04:32,FFPE空间转录组测序,8,/upload/science/2023/7/19/1689737456100.jpg,10x Visium CytAssist FFPE空间转录组采用探针法进行基因的杂交和表达检测，目前仅适用人、小鼠物种的FFPE样本。其中人有18000个基因的探针；小鼠有20000个基因的探针。FFPE表达芯片尺寸有6.5*6.5mm，11*11mm两种尺寸。,2023-07-19 11:38:27,/tech-service-detail?cid25&id86,Reactive,197,{id:198,createTime:199,updateTime:200,title:201,categoryId:164,serviceIndex:202,imagePath:203,summary:204,releaseTime:205,status:12,categoryName:166,statusName:25,link:206},87,2023-07-19 13:28:47,2024-01-31 17:04:48,Stereo-Seq时空转录组（华大）,9,/upload/science/2023/7/19/1689743620605.jpg,华大时空组学（Stereo-Seq）是一种基于DNA纳米球研发的产品，以时空芯片捕获组织样本中的mRNA，并进一步的采用时空条形码还原组织样本的空间位置信息，实现组织原位测序。,2023-07-19 13:50:15,/tech-service-detail?cid25&id87,{id:208,createTime:209,updateTime:210,title:211,subTitle:212,categoryIndex:43,imagePath:213,remark:211,isDelete:4,dropdownNavList:214,text:211,href:101},19,2023-06-24 17:39:54,2023-07-09 01:09:53,表观组学,Epigenomics,upload/science/2023/07/09/kjfw_03.jpg,215,224,231,238,245,252,262,Reactive,216,{id:217,createTime:218,updateTime:219,title:220,categoryId:208,serviceIndex:12,imagePath:221,summary:222,status:12,categoryName:211,statusName:25,link:223},52,2023-07-12 00:40:02,2023-07-18 14:05:19,全基因组甲基化测序(WGBS),/upload/201706/01/201706012309542528.jpg,简化甲基化测序(Reduced Representation Bisulfite Sequencing,RRBS)是利用限制性内切酶对基因组进行酶切，然后进行Bisulfite测序对基因组甲基化展开分析。该技术显著提高了CpG区域的测序深度，在CpG岛、启动子区域和增强子元件区域可以获得高精度…,/tech-service-detail?cid19&id52,Reactive,225,{id:226,createTime:218,updateTime:227,title:228,categoryId:208,serviceIndex:33,imagePath:221,summary:229,status:12,categoryName:211,statusName:25,link:230},53,2023-07-18 14:09:36,简化甲基化测序(RRBS),简化甲基化测序(Reduced Representation Bisulfite Sequencing,RRBS)是利用限制性内切酶对基因组进行酶切，然后进行Bisulfite测序对基因组甲基化展开分析。该技术显著提高了CpG区域的测序深度，在CpG岛、启动子区域和增强子元件区域可以获得高精度的分辨率。,/tech-service-detail?cid19&id53,Reactive,232,{id:233,createTime:218,updateTime:234,title:235,categoryId:208,serviceIndex:43,imagePath:221,summary:236,status:12,categoryName:211,statusName:25,link:237},54,2023-07-26 13:39:45,m6A测序/微量m6A测序（MeRIP-seq）,已知RNA上存在一百多种碱基修饰，其中m6A修饰为含量最高的一种修饰之一。在甲基化转移酶的作用下，腺嘌呤A发生修饰转化成m6A。而在去甲基化酶的作用下，m6A修饰重新转为普通的腺嘌呤A。,/tech-service-detail?cid19&id54,Reactive,239,{id:240,createTime:218,updateTime:241,title:242,categoryId:208,serviceIndex:53,imagePath:221,summary:243,status:12,categoryName:211,statusName:25,link:244},55,2023-07-26 13:21:22,ChIP-seq（染色质免疫共沉淀测序）,ChIP-seq全称Chromatin Immunoprecipitation sequencing，也叫染色质免疫共沉淀测序技术，是研究蛋白质与DNA相互作用的有力工具，通常用于转录因子结合位点或组蛋白特异性修饰位点的研究。将ChIP与二代测序技术相结合的ChIP-Seq技术，能够高效地在全基因组范围内检测与组蛋白、转录因子等互作的DNA区段。,/tech-service-detail?cid19&id55,Reactive,246,{id:247,createTime:218,updateTime:248,title:249,categoryId:208,serviceIndex:63,imagePath:221,summary:250,status:12,categoryName:211,statusName:25,link:251},56,2023-07-26 13:49:20,RIP-seq（ RNA免疫共沉淀测序）,RNA immunoprecipitation sequencing (RIP-seq)是RNA免疫共沉淀结合高通量测序的一种技术，通过免疫沉淀靶蛋白来捕获互作的RNA。其原理是运用针对目标蛋白的抗体把相应的RNA-蛋白复合物沉淀下来，然后经过分离纯化获得结合在复合物上的RNA，再通过高通量测序…,/tech-service-detail?cid19&id56,Reactive,253,{id:254,createTime:255,updateTime:256,title:257,categoryId:208,serviceIndex:202,imagePath:258,summary:259,releaseTime:260,status:12,categoryName:211,statusName:25,link:261},95,2024-04-11 14:04:50,2024-04-11 14:45:24,ATAC-seq,/upload/science/2024/4/11/1712815486714.jpg,ATAC-seq（Assay for Transposase Accessible Chromatin using sequencing）是一种利用转座酶 Tn5 来研究染色质可及性的高通量测序技术。ATAC-seq 的核心原理在于使用转座酶 Tn5 对开放染色质区域进行切割，并在此过程中将测序接头整合到这些区域的 DNA 上，随后，这些被接头标记的 DNA 片段会经过高通量测序，以识别在细胞核中开放的染色质区域。这些区域通常是基因组中易于与转录因子和其他调控蛋白相结合的部位。因此，ATAC-seq 是研究基因表达调控、细胞分化和疾病状态下的表观遗传变化的强大工具。,2024-04-11 14:20:42,/tech-service-detail?cid19&id95,Reactive,263,{id:264,createTime:265,updateTime:266,title:267,categoryId:208,serviceIndex:268,imagePath:269,summary:270,releaseTime:271,status:12,categoryName:211,statusName:25,link:272},96,2024-04-11 14:39:15,2024-04-11 14:44:49,CUT&Tag,12,/upload/science/2024/4/11/1712817553067.jpg,CUT&Tag（Cleavage Under Targets and Tagmentation）是蛋白-DNA 互作的一大革新技术，该技术核心为 Hyperactive pG-Tn5/pA-Tn5 Transposase，该酶是将Protein G/A 与经过工程学改造的超高活性 Tn5 转座酶进行融合，形成同时具备转座酶与 Protein G/A活性的新型融合酶，专门适用于蛋白质-基因组互作研究的 CUT&Tag 技术核心酶，在切割DNA片段的同时在序列两端加上测序接头，经PCR扩增后形成可以直接用于高通量测序的文库。,2024-04-11 14:40:21,/tech-service-detail?cid19&id96,{id:274,createTime:275,updateTime:276,title:277,subTitle:278,categoryIndex:53,imagePath:279,remark:277,isDelete:4,dropdownNavList:280,text:277,href:101},20,2023-07-09 01:04:11,2023-07-09 01:08:47,微生物组学,Microbiome,upload/science/2023/07/09/kjfw_04.jpg,281,291,301,311,321,331,Reactive,282,{id:283,createTime:284,updateTime:285,title:286,categoryId:274,serviceIndex:12,imagePath:287,summary:288,releaseTime:289,status:12,categoryName:277,statusName:25,link:290},81,2023-07-18 14:29:47,2023-07-25 17:03:07,宏基因组测序,/upload/science/2023/7/18/1689661334836.jpg,宏基因组测序（Metagenomics Sequencing）是对环境样品中的微生物群落的基因组进行高通量测序，主要研究微生物种群结构、基因功能活性、微生物之间的相互协作关系以及微生物与环境之间的关系。,2023-07-18 14:31:05,/tech-service-detail?cid20&id81,Reactive,292,{id:293,createTime:294,updateTime:295,title:296,categoryId:274,serviceIndex:33,imagePath:297,summary:298,releaseTime:299,status:12,categoryName:277,statusName:25,link:300},82,2023-07-18 17:06:15,2023-07-25 16:10:01,宏转录组测序,/upload/science/2023/7/18/1689670710983.jpg,宏转录组测序（Metatranscriptomics sequencing）是在转录水平，以特定样本中微生物群落的全部转录本为研究对象，分析微生物群落的基因表达与调控。相比于扩增子测序，宏转录组测序可以给研究者提供更丰富的微生物群落的基因表达信息、功能信息以及参与的通路信息，更有助于阐释微生物群落与宿主或是环境的相互作用。,2023-07-19 11:19:11,/tech-service-detail?cid20&id82,Reactive,302,{id:303,createTime:304,updateTime:305,title:306,categoryId:274,serviceIndex:43,imagePath:307,summary:308,releaseTime:309,status:12,categoryName:277,statusName:25,link:310},85,2023-07-19 11:26:55,2023-07-25 15:58:38,微生物群落多样性（16S/ITS测序）,/upload/science/2023/7/19/1689750561580.jpg,扩增子测序常用于微生物群落的多样性分析。16S rDNA测序（v3-v4）和ITS测序（ITS2）常分别用于细菌群落和真菌群落的多样性分析。联川生物的扩增子测序数据分析已全面使用QIIME 2流程，不再使用传统的基于OTU的分析方法，调用DADA2对原始数据进行去噪，相当于按照100%的相似性聚类，进而获得单碱基精度的代表序列，结果更丰富，更真实的还原微生物群落结构。,2023-07-19 15:09:39,/tech-service-detail?cid20&id85,Reactive,312,{id:313,createTime:314,updateTime:315,title:316,categoryId:274,serviceIndex:53,imagePath:317,summary:318,releaseTime:319,status:12,categoryName:277,statusName:25,link:320},89,2023-07-19 14:33:21,2023-07-25 16:08:12,植物内生菌多样性测序,/upload/science/2023/7/19/1689747829746.jpg,内生菌长期生活在植物体的特殊环境里，并和宿主协同进化，在演变过程中二者形成了互利共生关系，一方面植物为内生菌提供光合产物和矿物质供内生菌生长需要，另一方面内生菌在宿主的生长发育和系统演化过程中起重要作用。植物内生菌多样性测序即是对植物体内的细菌或真菌群落组成进行鉴定。,2023-07-19 16:41:36,/tech-service-detail?cid20&id89,Reactive,322,{id:323,createTime:324,updateTime:325,title:326,categoryId:274,serviceIndex:63,imagePath:327,summary:328,releaseTime:329,status:12,categoryName:277,statusName:25,link:330},90,2023-07-21 09:51:17,2023-07-25 16:07:07,肿瘤微生物测序,/upload/science/2023/7/21/1689902515131.jpg,研究人员早已在肿瘤内发现了细菌的存在，但因其生物量低，全面描述肿瘤微生物组的特征极具挑战性。肿瘤内的细菌已被发现具有肿瘤特异性，并且已有的机制研究表明，肿瘤内微生物群可能直接调节肿瘤的发生、发展，以及对化疗或免疫治疗的应答。2020年两项重量级的肿瘤内微生物组研究相继在Nature和Science上发表，标志着研究人员可以借助高通量测序技术对肿瘤内的微生物组开展全面且深入地研究，更进一步地揭示微生物在肿瘤中的作用。,2023-07-21 09:53:04,/tech-service-detail?cid20&id90,Reactive,332,{id:333,createTime:334,updateTime:335,title:336,categoryId:274,serviceIndex:74,imagePath:337,summary:338,releaseTime:339,status:12,categoryName:277,statusName:25,link:340},60,2023-07-12 00:45:27,2023-07-25 17:13:51,功能基因多样性测序,/upload/science/2023/7/25/1690272824829.jpg,在自然界的各类环境中，都有微生物的存在，它们在各自的“岗位”上都发挥着或大或小、或多或少的作用。有一些具有特殊功能的微生物，由于其作用的重要性或特殊性而受到人们的广泛关注，它们就叫做功能微生物，如固氮菌、反硝化菌、氨氧化细菌、甲烷氧化菌等。每种功…,2023-07-25 17:15:04,/tech-service-detail?cid20&id60,{id:342,createTime:343,updateTime:344,title:345,subTitle:346,categoryIndex:63,imagePath:347,remark:346,isDelete:4,dropdownNavList:348,text:345,href:101},21,2023-07-09 01:04:54,2023-07-09 01:08:55,蛋白与代谢组学,Proteomics,upload/science/2023/07/09/kjfw_05.jpg,349,358,368,375,382,388,394,401,Reactive,350,{id:351,createTime:352,updateTime:353,title:354,categoryId:342,serviceIndex:12,imagePath:355,summary:356,status:12,categoryName:345,statusName:25,link:357},62,2023-07-12 00:51:14,2023-07-20 08:34:42,代谢全谱分析/非靶代谢组学,/upload/201706/01/201706012310021263.jpg,背景简介 代谢全谱为非靶向代谢组学分析，采用色谱-质谱联用技术采集样品的代谢谱图，比较不同组样品代谢产物的含量，鉴定差异表达的代谢物，并探索差异代谢物之间的代谢通路。代谢组学分析技术已广泛应用于疾病诊断、药物靶点发现、疾病机理研究、营养食品科学、毒理学…,/tech-service-detail?cid21&id62,Reactive,359,{id:360,createTime:361,updateTime:362,title:363,categoryId:342,serviceIndex:33,imagePath:364,summary:365,releaseTime:366,status:12,categoryName:345,statusName:25,link:367},93,2024-02-04 14:45:23,2024-02-04 16:49:29,空间代谢组,/upload/science/2024/2/4/1707028453329.jpg,空间代谢组学整合了质谱成像技术（Mass spectrometry imaging，MSI）和传统代谢组学技术，能够获取代谢物在组织中的位置信息，实现对生物学样本的代谢物定性、定量和空间分布的检测。突破了传统代谢物组学研究损失空间信息的瓶颈，为传统代谢物组学分析提供了全新的可视化视角。,2024-02-04 14:50:31,/tech-service-detail?cid21&id93,Reactive,369,{id:370,createTime:352,updateTime:371,title:372,categoryId:342,serviceIndex:33,imagePath:355,summary:373,status:12,categoryName:345,statusName:25,link:374},63,2023-07-20 08:32:48,微量/单细胞蛋白组学,产品介绍1.1 背景介绍常规的蛋白质组学需要一定的蛋白量才能进行后续的组学服务，本产品使用微量的细胞样品（200个细胞即可），就可以进行蛋白质组学研究。细胞是常见的组学研究样本。本产品线的主要特点是需求样本量少，可满足客户低样本量检测需求。1.2 技术优势通过芯片的纳…,/tech-service-detail?cid21&id63,Reactive,376,{id:377,createTime:352,updateTime:378,title:379,categoryId:342,serviceIndex:43,imagePath:355,summary:380,status:12,categoryName:345,statusName:25,link:381},64,2023-07-13 00:55:22,TMT标记定量蛋白质组学,背景简介 TMT™（Tandem Mass Tag™）技术是由美国Thermo Scientific公司研发的一种多肽体外标记技术。该技术采用10种同位素的标签，通过特异性标记蛋白多肽N末端或赖氨酸侧链基团，而后进行串联质谱分析，可同时比较10组不同样品中蛋白质的相对含量。TMT技术是常用的差异蛋白…,/tech-service-detail?cid21&id64,Reactive,383,{id:384,createTime:352,updateTime:378,title:385,categoryId:342,serviceIndex:53,imagePath:355,summary:386,status:12,categoryName:345,statusName:25,link:387},65,Labelfree蛋白质组定量,背景简介 蛋白质非标记定量技术（label-free）是通过液质联用技术对蛋白质酶解肽段进行质谱分析，无需使用昂贵的稳定同位素标签做内部标准，只需分析大规模鉴定蛋白质时所产生的质谱数据，比较不同样品中相应肽段的信号强度，从而对肽段对应的蛋白质进行相对定量。与iTRAQ技术…,/tech-service-detail?cid21&id65,Reactive,389,{id:390,createTime:352,updateTime:378,title:391,categoryId:342,serviceIndex:63,imagePath:355,summary:392,status:12,categoryName:345,statusName:25,link:393},66,DIA定量与检测,背景简介 数据非依赖性的扫描模式(Data-independent acquisition, DIA)是近几年来发展的一种新的质谱数据采集方式。可以对特定质量范围内的所有母离子进行碎裂，采集所有母离子的碎片离子信息进行蛋白定性和定量。目前流行的蛋白质组学研究手段，如iTRAQTMT、 Label-fr…,/tech-service-detail?cid21&id66,Reactive,395,{id:396,createTime:352,updateTime:397,title:398,categoryId:342,serviceIndex:74,imagePath:355,summary:399,status:12,categoryName:345,statusName:25,link:400},67,2023-07-20 08:34:12,4D-DIA/labelfree,4D蛋白质组是新一代蛋白质组学分析技术， 由布鲁克公司与蛋白质组学领域的领军人物Matthias Mann， Ruedi Aebersold， Jrgen Cox ， Ben Collins和Hannes Roest等科研团队合作推出的技术。4D-Proteomics™： 在传统保留时间（retention time）、质荷比（m/z）、离子…,/tech-service-detail?cid21&id67,Reactive,402,{id:403,createTime:352,updateTime:404,title:405,categoryId:342,serviceIndex:85,imagePath:355,summary:406,status:12,categoryName:345,statusName:25,link:407},68,2023-08-22 10:20:48,Olink蛋白质组学,Olink采用具有独立知识产权的PEA（Proximity Extension Assay，邻位延伸分析技术），将带有特有核苷酸序列探针的一对抗体与被检测蛋白质特异性结合，正确且邻位探针通过末端5bp配对碱基互补结合，在延伸酶的作用下形成双链模板，利用qPCR或NGS进行检测，通过特异性的核苷酸序列…,/tech-service-detail?cid21&id68,{id:409,createTime:410,updateTime:411,title:412,subTitle:413,categoryIndex:74,imagePath:414,remark:412,isDelete:4,dropdownNavList:415,text:412,href:101},22,2023-07-09 01:05:24,2023-07-09 01:09:03,基因组学,Genomics,upload/science/2023/07/09/kjfw_06.jpg,416,425,432,438,444,Reactive,417,{id:418,createTime:419,updateTime:420,title:421,categoryId:409,serviceIndex:33,imagePath:422,summary:423,status:12,categoryName:412,statusName:25,link:424},70,2023-07-12 00:55:54,2023-07-13 00:58:50,基因组重测序,/upload/201706/10/201706101442224588.jpg,背景介绍基因组重测序是对已知基因组序列的物种进行全基因组范围的测序，并在此基础上对个体或群体进行差异性（SNP、InDel和SV等）分析。基于基因组重测序技术，可以快速进行资源普查筛选，寻找到大量遗传变异，实现遗传进化分析及重要性状候选基因的预测。随着测序成本降低以…,/tech-service-detail?cid22&id70,Reactive,426,{id:427,createTime:419,updateTime:428,title:429,categoryId:409,serviceIndex:43,imagePath:422,summary:430,status:12,categoryName:412,statusName:25,link:431},71,2023-07-19 14:27:36,外显子组测序,外显子组（Exome）是一个物种基因组中全部外显子（Exon）区域的总和，该区域包含着合成蛋白质所需要的信息，涵盖了与个体表型相关的大部分的功能性变异。,/tech-service-detail?cid22&id71,Reactive,433,{id:434,createTime:419,updateTime:420,title:435,categoryId:409,serviceIndex:53,imagePath:422,summary:436,status:12,categoryName:412,statusName:25,link:437},72,遗传图谱,产品介绍 遗传图谱也叫连锁遗传图谱（Geneticlinkage map），是指基因或DNA分子标记在染色体水平上的相对位置与遗传距离，通常以基因或DNA片段在染色体交换过程中的重组频率来描述，单位为厘摩尔（cM）。例如两个基因或两个分子标记之间的遗传距离为0.8cM表示减数分裂时的…,/tech-service-detail?cid22&id72,Reactive,439,{id:440,createTime:419,updateTime:420,title:441,categoryId:409,serviceIndex:63,imagePath:422,summary:442,status:12,categoryName:412,statusName:25,link:443},73,全基因组关联分析(GWAS）,背景简介 GWAS(Genome-wide association study)，即全基因组关联分析，是指在人类全基因组范围内找出存在的序列变异，即单核苷酸多态性(SNP)，从中筛选出与疾病相关的SNPs。全基因组关联研究是一种检测特定物种中不同个体间的全部或大部分基因，从而了解不同个体间的基因变化…,/tech-service-detail?cid22&id73,Reactive,445,{id:446,createTime:419,updateTime:420,title:447,categoryId:409,serviceIndex:74,imagePath:422,summary:448,status:12,categoryName:412,statusName:25,link:449},74,BSA性状定位/Graded-seq,背景简介 Bulked-segregant analysis简称BSA，也叫混合分组分析，是一种利用样本混池的建库方式对动植物的极端性状进行QTL定位的一种方法。这种方法快速便捷，在亲本群体中选择表型极端的个体构建表型极端的子代群体，并对极端性状的子代群体进行混池测序，从而迅速定位…,/tech-service-detail?cid22&id74,{id:451,createTime:452,updateTime:453,title:454,categoryIndex:85,imagePath:455,remark:456,isDelete:4,dropdownNavList:457,text:454,href:101},23,2023-07-10 14:09:11,2023-07-24 08:46:01,多组学联合分析（开发中）,upload/science/2023/7/10/1688977333269.png,多组学联合分析,,{code:4,datas:459,totalCount:85},460,468,475,480,486,490,493,{id:461,createTime:462,title:463,categoryId:464,bannerIndex:12,imagePath:465,remark:466,isDelete:4,categoryName:467},29,2024-07-08 15:18:07,联川olink用户文章新英格兰医学杂志if158.5,14,https://www.lc-bio.com//upload/banner/2024/7/8/1720422988219.jpg,无,首页banner,{id:469,createTime:470,updateTime:471,title:472,categoryId:464,bannerIndex:12,imagePath:473,remark:474,isDelete:4,categoryName:467},27,2024-03-22 17:21:05,2024-03-22 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10:50:57,组织基因组DNA提取试剂盒,/upload/productCategory/2024/1/9/1704768656354.jpg,/product?id26&title注册试剂&img/upload/productCategory/2024/3/11/1710148083260.jpg,{id:514,createTime:515,level:33,parentId:501,title:516,subTitle:516,imagePath:517,categoryIndex:12,remark:516,isDelete:4,subCategoryId:501,link:512},31,2024-01-09 08:50:29,DNA纯化磁珠,/upload/productCategory/2024/1/9/1704761418637.jpg,{id:519,createTime:520,updateTime:521,level:33,parentId:501,title:522,subTitle:522,imagePath:523,categoryIndex:33,remark:522,isDelete:4,subCategoryId:501,link:512},32,2024-01-09 09:19:58,2024-01-09 09:40:02,全血基因组DNA提取试剂盒（磁珠法）,/upload/productCategory/2024/1/9/1704764400701.jpg,{id:525,createTime:526,level:33,parentId:501,title:527,subTitle:527,imagePath:528,categoryIndex:53,remark:527,isDelete:4,subCategoryId:501,link:512},33,2024-01-09 09:53:12,人EGFR、BRAF、KRAS、ALK、ROS1基因突变联合检测试剂盒（可逆末端终止测序法）,/upload/productCategory/2024/1/9/1704765185162.jpg,530,531,532,533,Reactive,507,Reactive,513,Reactive,518,Reactive,524,{id:469,createTime:535,level:12,parentId:4,title:536,subTitle:536,imagePath:537,categoryIndex:12,remark:536,isDelete:4,subCategoryId:4,sonNodes:538,dropdownNavList:571,text:536,href:545},2023-12-11 09:40:18,科研试剂,/upload/productCategory/2023/12/11/1702258810313.jpg,539,546,551,556,561,566,{id:540,createTime:541,updateTime:542,level:33,parentId:469,title:543,subTitle:543,imagePath:544,categoryIndex:33,remark:543,isDelete:4,subCategoryId:469,link:545},28,2023-12-11 09:42:56,2024-01-09 09:47:48,动物组织总RNA提取试剂盒（磁珠法）,/upload/productCategory/2024/1/9/1704764863694.jpg,/product?id27&title科研试剂&img/upload/productCategory/2023/12/11/1702258810313.jpg,{id:461,createTime:547,updateTime:548,level:33,parentId:469,title:549,subTitle:549,imagePath:550,categoryIndex:43,remark:549,isDelete:4,subCategoryId:469,link:545},2024-01-08 17:29:08,2024-01-09 09:48:31,Purification Beads 006,/upload/productCategory/2024/1/9/1704764908938.jpg,{id:552,createTime:553,level:33,parentId:469,title:554,subTitle:554,imagePath:555,categoryIndex:12,remark:554,isDelete:4,subCategoryId:469,link:545},30,2024-01-09 08:20:14,粪便基因组DNA提取试剂盒（磁珠法）,/upload/productCategory/2024/1/9/1704759609093.jpg,{id:557,createTime:558,level:33,parentId:469,title:559,subTitle:559,imagePath:560,categoryIndex:53,remark:559,isDelete:4,subCategoryId:469,link:545},34,2024-01-09 10:30:21,粪便样本保存管,/upload/productCategory/2024/1/9/1704767418943.jpg,{id:562,createTime:563,level:33,parentId:469,title:564,subTitle:564,imagePath:565,categoryIndex:63,remark:564,isDelete:4,subCategoryId:469,link:545},35,2024-01-09 10:58:14,RNA-seq组织保存液,/upload/productCategory/2024/1/9/1704769093210.jpg,{id:567,createTime:568,level:33,parentId:469,title:569,subTitle:569,imagePath:570,categoryIndex:74,remark:569,isDelete:4,subCategoryId:469,link:545},36,2024-01-09 11:25:08,Purification Beads 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13:43:58,2024-07-25 13:47:13,校企合作新风尚，联川生物携手浙理工开启生物信息学新课堂,https://www.lc-bio.com//upload/science/2024/7/25/1721885878352.jpg,浙江理工大学生物信息学微专业开课仪式的成功举办，不仅为学员们提供了一个优质的学习平台和实践机会，也为校企合作树立了新的典范。相信在双方的共同努力下，生物信息学领域将会迎来更加美好的未来！让我们携手并进、共创辉煌！,2024-07-25 13:44:04,企业要闻,/about-detail?index5&newsTypedetail&id313,{id:625,createTime:626,updateTime:627,title:628,categoryId:274,informationIndex:12,imagePath:629,summary:630,releaseTime:631,status:12,categoryName:622,statusName:25,link:632},310,2023-07-19 15:42:07,2023-07-19 15:43:25,联川生物跻身国家级专精特新“小巨人”企业名单,https://www.lc-bio.com//upload/science/2023/7/19/1689752596284.jpg,7月14日，根据工信部统一部署，浙江省经济和信息化厅发布了《关于浙江省第五批专精特新“小巨人”企业和第二批专精特新“小巨人”复核通过企业名单的公示》，联川生物榜上有名！,2023-07-19 15:44:37,/about-detail?index5&newsTypedetail&id310,{id:33,createTime:634,updateTime:635,title:636,categoryId:274,informationIndex:12,imagePath:637,summary:638,status:12,categoryName:622,statusName:25,link:639},2022-03-23 17:14:04,2023-07-12 01:31:42,关于杭州联川生物医药科技有限公司基因科技产品及服务平台扩产升级项目有关情况的公示,https://www.lc-bio.com//upload/202203/23/202203231705301265.png,根据浙江省人民政府办公厅关于全面推行“区域环评+环境标准”改革的指导意见（浙政办发〔2017 ) 57 号）和《杭州钱塘新区“区域环评+环境标准”改革实施方案》(钱塘管办发(2019) 54号)要求，我公司现将《杭州联川生物医药科技有限公司基因科技产品及服务平台扩产升级项目“区域…,/about-detail?index5&newsTypedetail&id2,308,{},{6W8l71VhzM:643,ZnpEkciXG7:643,031X7Q9U1q:643,alRqIOlioq:643,DjgZsauEtM:643,RN0rC5JpWO:643,bNQpw0TksX:643,CyGwzluQvt:643,113d650sm9:643,KQKFDPp9UK:643,o6HEvWhdsF:643,2wPHVM5snr:643,hwSMj3ZHOP:643,S2QJfaO5dT:643},null,true/script>script>window.__NUXT__{};window.__NUXT__.config{public:{},app:{baseURL:/,buildAssetsDir:/_nuxt/,cdnURL:}}/script>script typemodule src/_nuxt/entry.09d0aa3c.js crossorigin>/script>/body>/html>
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