Domain > www.humirapro.com

More information on this domain is in AlienVault OTX

DNS Resolutions

Date	IP Address
2020-04-29	143.204.142.24 (ClassC)
2020-06-23	13.249.71.63 (ClassC)
2020-06-23	13.249.71.64 (ClassC)
2021-06-09	65.8.227.7 (ClassC)
2021-06-09	65.8.227.86 (ClassC)
2024-11-18	204.246.191.128 (ClassC)

HTTP/1.1 200 OKContent-Type: text/html;charsetutf-8Content-Length: 203327Connection: keep-aliveDate: Mon, 18 Nov 2024 19:57:15 GMTSet-Cookie: AWSALBV/cK0JIs8ncUjHEsTMUqzn14nT0AdKnPgSb9M4m/Tv/U7lmHnEKIUl4eBDsHJY6O1sRdE8nMApYp1M7dnpnU/QUliYIE5Hv3yVMVmnkrdqHhp9Ynhlg7PUe5DdfH; ExpiresMon, 25 Nov 2024 19:57:15 GMT; Path/Set-Cookie: AWSALBCORSV/cK0JIs8ncUjHEsTMUqzn14nT0AdKnPgSb9M4m/Tv/U7lmHnEKIUl4eBDsHJY6O1sRdE8nMApYp1M7dnpnU/QUliYIE5Hv3yVMVmnkrdqHhp9Ynhlg7PUe5DdfH; ExpiresMon, 25 Nov 2024 19:57:15 GMT; Path/; SameSiteNone; SecureServer: X-Frame-Options: SAMEORIGINStrict-Transport-Security: max-age31536000; includeSubDomainsX-Content-Type-Options: nosniffLast-Modified: Fri, 15 Nov 2024 12:07:58 GMTETag: 31a3f-626f26af87f15Accept-Ranges: bytesX-Dispatcher: dispatcher1useast1-b80X-Vhost: publishCache-Control: max-age0, s-maxage86400Vary: Accept-EncodingX-Cache: Hit from cloudfrontVia: 1.1 87cff53a3b3c669d865b820d148e2d62.cloudfront.net (CloudFront)X-Amz-Cf-Pop: HIO50-C2X-Amz-Cf-Id: yvx7B3KPgyGk8lUZWpX5SemIyhU5UaTNVop3ApbzbnsrNLCEj1KTdwAge: 1261

!DOCTYPE HTML>html langen-US>                        head>meta http-equivcontent-type contenttext/html; charsetUTF-8/>meta charsetutf-8/>meta nameviewport contentwidthdevice-width, initial-scale1/>					link relshortcut icon sizes196x196 href/content/dam/humirapro/images/favicon.png/_jcr_content/renditions/cq5dam.thumbnail.196.196.png/>					link relapple-touch-icon sizes180x180 href/content/dam/humirapro/images/favicon.png/_jcr_content/renditions/cq5dam.thumbnail.180.180.png/>					link relapple-touch-icon sizes120x120 href/content/dam/humirapro/images/favicon.png/_jcr_content/renditions/cq5dam.thumbnail.120.120.png/>					link relapple-touch-icon sizes167x167 href/content/dam/humirapro/images/favicon.png/_jcr_content/renditions/cq5dam.thumbnail.167.167.png/>					link relapple-touch-icon sizes57x57 href/content/dam/humirapro/images/favicon.png/_jcr_content/renditions/cq5dam.thumbnail.57.57.png/>					link relapple-touch-icon sizes152x152 href/content/dam/humirapro/images/favicon.png/_jcr_content/renditions/cq5dam.thumbnail.152.152.png/>					link relicon sizes32x32 href/content/dam/humirapro/images/favicon.png/_jcr_content/renditions/cq5dam.thumbnail.32.32.png/>	!-- Custom Meta tags added as authored -->								meta contentHUMIRA® (adalimumab) Healthcare Professional Site propertyog:title/>										meta contentFind HUMIRA full prescribing information including Important Safety Information and the BOXED WARNING. propertyog:description/>										meta contenthttps://www.humirapro.com/content/dam/humirapro/seo/HUMIRA%20Pro%20OG%20Image.png propertyog:image/>										meta contenthttps://www.humirapro.com propertyog:url/>										meta content349686310249732 propertyfb:app_id/>										meta contentWebsite propertyog:type/>										meta contentHUMIRA For Healthcare Professionals propertyog:site_name/>				!-- **** MRP Meta Tags **** -->!-- ****Removed redirect.html from body and added in head to fix server side redirection **** -->	    link reldns-prefetch hrefhttps://use.typekit.net/>    link reldns-prefetch hrefhttps://p.typekit.net/>    link reldns-prefetch hrefhttps://dpm.demdex.net/>    link reldns-prefetch hrefhttps://fast.abbviecommercial.demdex.net/>    link reldns-prefetch hrefhttps://abbviecommercial.demdex.net/>    link reldns-prefetch hrefhttps://abbviecommercial.tt.omtrdc.net/>    link reldns-prefetch hrefhttps://smetrics.abbvie.com/>    link reldns-prefetch hrefhttps://assets.adobedtm.com/>                    meta namekeywords content/>                meta namedescription contentHUMIRA is indicated for the treatment of rheumatology, dermatology, and gastroenterology indications. Review efficacy, safety data, and more./>                        meta namelanguage contenten/>                    meta namecountry contentUS/>            meta namepagename contentHUMIRA® (adalimumab) | For Healthcare Professionals/>    meta nametemplatename contentfull-width-content-page/>    meta namepageurl content//>            meta namefranchise contentCross Franchise (Cross)/>                    meta namecontent-journey contentHome/>                    meta namepatient-journey contenthumirapro-hcp|br|cross|cros|homepage/>                        meta nameforcedmodaloverlay contentno/>                    meta nameindication-id content/>                meta namesitename contentHumirapro/>                    meta nameglobalisi contentUS-HUM-210183/>                    meta nameepassnumber contentUS-HUM-220512/>        						    script src/etc/clientlibs/common-elements/clientlibs/plugins/clientlib.min.d2454d9f632f1f286ab2bca6de3f7e29.js>/script>				                link relstylesheet href/etc/clientlibs/common-elements/clientlibs/v1/css-clientlib-all.min.c5b95a85772a4c317f0a2b728ae6a67a.css typetext/css>                    !-- Site Level CSS -->            link relpreload href/content/dam/humirapro/css/HUMD-ITS-1018/HumiraPro.css asstyle/>        link relstylesheet href/content/dam/humirapro/css/HUMD-ITS-1018/HumiraPro.css typetext/css/>        !-- Page Level CSS -->                                                                            script>        window.AbbViePageInfo  {            loginPage : ,            forcedLogin : ,            editState: false,            pagepath: /content/humirapro/en-us,            adminConfigPath: /content/admin/humirapro/en-us,            apiEndPoints: {getPatientFullfilment: /api/BrandAPIGateway/api/V2/PatientFulfillment/GetPatientFulfillment,saveAssessment: /api/BrandAPIGateway/api/Assessment/Save,physicianLookUp: /api/BrandAPIGateway/api/Physician/LookUp,getAssessment: /api/BrandAPIGateway/api/Assessment/Get,getAggregated: /api/BrandAPIGateway/api/Assessment/GetAggregated,refreshToken: /bin/abbvieforms/refreshlogin,getSearchSuggestions: /suggest,getSearchResults: /search,apigeePhysicianLookUp: /bin/abbvie/apiproxy},            share: {copy:{text:,showSuccess:false,enable:false},email:{modalID:,enable:false},facebook:{url:https://www.facebook.com/sharer/sharer.php?u,enable:false},twitter:{url:https://www.twitter.com/share?url,enable:false},linkedin:{url:https://www.linkedin.com/shareArticle?minitrue&url,enable:false},tumblr:{url:https://www.tumblr.com/widgets/share/tool?canonicalUrl,enable:false},pinterest:{url:https://pinterest.com/pin/create/button/?url,enable:false},instagram:{url:https://instagram.com/share?uri,enable:false},exitModal:{modalID:}},            brandConfig : fm-brandname-humirapro,            headers:,            targetTimeout: 1000,            timeOut :,            originNames:,            indicationName : ,            indicationReset : false,            epassNumber : US-HUM-220512,            indicationAware : true,            indicationEndPoints :{                header: /{{indication}}/jcr:content/headerIpar.html,                footer: /{{indication}}/jcr:content/footerIpar.html,                safetyBar: /{{indication}}/jcr:content/safetybar.html,                inlineUse: /content/global/en-us/humira/professional/{{indication}}/use/jcr:content/contentpar.html,                inlineISI: /content/global/en-us/humira/professional/{{indication}}/isi/jcr:content/contentpar.html            },            campaignConfig : {sids:{},emids:{},qids:{},videooptionids:{},eids:{},optionids:{}},            runModes: prod, s7connect, crx3, nosamplecontent, publish, crx3tar,            friendlyNames: ,            coveoSearchHub:humirapro-search,            coveoSearchUrl:https://platform.cloud.coveo.com/rest/search,            coveoOrganizationId:abbvieincproductionyd9g1cpe,            coveoHostedSearchPageAPIKey:xx63ab8217-2b82-4c4a-967f-d6894f422ff3,            coveoQuerySuggestionsEnabled:false,            admpInvisibleEntRecaptchaSitekey : 6Ld-4xkiAAAAAIqU4DUDupoGer6ss43KQeOGEtk0,            maxComponentCount: 100,            headerInheritance: ,            footerInheritance: ,            safetybarInheritance: ,            globalFooterLinks: { 	"findLinkText": "PRIVACY POLICY", 	"newLinkText": "Consumer Health Data Privacy Notice", 	"newLinkUrl": "https://abbv.ie/PrivacyConsumerHealth", 	"language": "en" }, { 	"findLinkText": "PRIVACY Notice", 	"newLinkText": "Consumer Health Data Privacy Notice", 	"newLinkUrl": "https://abbv.ie/PrivacyConsumerHealth", 	"language": "en" }, { 	"findLinkText": "Aviso De privacidad", 	"newLinkText": "Aviso de Privacidad de los Datos de Salud de los Consumidores", 	"newLinkUrl": "https://abbv.ie/PrivacidadConsumidores", 	"language": "es" }, { 	"findLinkText": "Aviso De privacidad", 	"newLinkText": "Aviso de Privacidad de los Datos de Salud de los Consumidores", 	"newLinkUrl": "https://abbv.ie/PrivacidadConsumidores", 	"language": "es-pr" },            pageAudienceType: Health Care Professional (HCP)        };        /script>                script>//Dont use let/const for global definitions here b/c this code is also in pre-load-utils.js////Add constants herevar MEDIA_DESKTOP  985;  //desktop everything > 985var MEDIA_TABLET  601;   //tablet everything > 600 and  985var MEDIA_MOBILE  600;   //mobile  600function arrayBufferToBase64(buffer) {	var binary  ;	var bytes  new Uint8Array(buffer);	var len  bytes.byteLength;	for (var i  0; i  len; i++) {		binary + String.fromCharCode(bytesi);	}	return window.btoa(binary);}function base64ToArrayBuffer(base64) {	var binary_string  window.atob(base64);	var len  binary_string.length;	var bytes  new Uint8Array(len);	for (var i  0; i  len; i++) {		bytesi  binary_string.charCodeAt(i);	}	return bytes.buffer;}// Browser Detectionvar browserAgent  (function() {	var bAgents  {		opera   : { status : false, browser: opera         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safari.pushNotification));			// Internet Explorer 6-11			// bAgentsie.status  true;			bAgentsie.status  !!document.documentMode;			// Edge 20+			bAgentsedge.status  !bAgentsie.status && !!window.StyleMedia;			// Chrome 1 - 71			bAgentschrome.status  !!window.chrome && (!!window.chrome.webstore || !!window.chrome.runtime);			// Blink engine detection			bAgentsblink.status  (bAgentschrome.status || bAgentsopera.status) && !!window.CSS;			// Touch Device			bAgentstouch.status  ontouchstart in document.documentElement;			// Mobile Chrome			bAgentsmChrome.status  (window.navigator.userAgent.indexOf(Android) > -1 && (/Chrome\/.0-9*/).test(window.navigator.userAgent)) || navigator.userAgent.match(CriOS);			// Mobile Safari			bAgentsmSafari.status  /Mac OS X|iP(ad|od|hone)/i.test(window.navigator.userAgent) && /WebKit/i.test(window.navigator.userAgent) && !(/(CriOS|FxiOS|OPiOS|mercury)/i.test(window.navigator.userAgent));			// Print browser name into html tag			var htmlObj  document.getElementsByTagName(html)0;			for(var prop in bAgents){				if(bAgentsprop.status) { htmlObj.classList.add(abbv-browser- + bAgentsprop.browser); }			}		},		checkIfBrowser : function(ifBrowser){			return bAgentsifBrowser.status;		},		printObj : function(){			console.log(bAgents);		}	};})();var cookieObj  (function() {	//NOTE: Unlikely that we have cookie names/values with spaces or special characters, but encode/decode just in case	//NOTE: Chrome now sets a max cookie age of 400, even if a larger value is passed	return {		init: function() {			// no longer needed - left for back-compat (forms code)		},		/**		 * Retrieve a cookie value		 * @param {String} name cookie name		 * @returns {String} cookie value, or undefined if not found		 */		getCookie: function(name) {			if (!name) {				return undefined;			}			name  encodeURIComponent(name);			let value  document.cookie.split(; ).find((c) > c.startsWith(name + ));			return value ? decodeURIComponent(value.split()1) : undefined; 		},		/**		 * Set a cookie value on root path		 * @param {String} name cookie name 		 * @param {String} value cookie value		 * @param {Number} days0 number of days for cookie to persist. 0 (falsy value) sets session cookie. Negative value deletes cookie.		 * @param {Boolean} notSecurefalse true to set unsecure cookie (not advised)		 */		createCookie: function(name, value, days, notSecure) {			let expires;			if (days) {				let date  new Date();				date.setTime(date.getTime() + (days * 24 * 60 * 60 * 1000));				expires  ; expires + date.toGMTString();			} else {				expires  ;  //session cookie			}			document.cookie  encodeURIComponent(name) +  + encodeURIComponent(value) + expires + ; path/; + (notSecuretrue ?  : secure);			//Should evaluate any cookies explicity set to unsecure			if (notSecure  true) {				console.log(cookieObj: wrote unsecure cookie - name + name);			}		},		/**		 * Delete a cookie		 * @param {String} name cookie name		 */		deleteCookie: function(name) {			this.createCookie(name, , -1);		}	};})();var urlObj  (function() {	var queryVars  {};	var queryVarsU  {};	return {		init : function(){			urlObj.analzeQuery();		},		analzeQuery : function(){			var qString  window.location.search.split(?)1;			if(qString ! undefined){				var temp  qString.split(&);				for(let i  0; i  temp.length; i++){					let tempSplit  tempi.split();					queryVarstempSplit0  tempSplit1;					queryVarsUtempSplit0.toUpperCase()  tempSplit1;				}			}		},		getParam : function(key, caseSensative){			caseSensative  caseSensative  undefined ? true : caseSensative;			let val;			if(caseSensative  true){ val  decodeURIComponent(queryVarsencodeURIComponent(key));}			else { val  decodeURIComponent(queryVarsUencodeURIComponent(key.toUpperCase()));}			return val;		},		getParamsObj : function (){			return queryVars;		},		getParamsObjU : function (){			return queryVarsU;		},		printObj : function(){			console.log(queryVars);			console.log(queryVarsU);		}	};})();var campaignTracking  (function() {	var idTables;	var gpf_payload  {};	var sa_payload  {		CampaignMasterId:,		CompleteDate:null,		ConsumerId:,		IndividualId:,		AssessmentQuestion: {			QuestionId:,			QuestionOptions:{				OptionId:,				ResponseText:			}		},		OtherInformation:{}	};	var questionLookupReq  false;	var saveReady  false;	return {		init : function(){			idTables  AbbViePageInfo.campaignConfig;      		AbbViePageInfo.campaignTracking  {};			if(campaignTracking.getIndividualID()){				// console.log(-- Individual ID Found --);				AbbViePageInfo.campaignTracking.individualID  sa_payload.IndividualId;				if(campaignTracking.getCampaignMasterID()){					// console.log(-- Campaign Master ID Found --);					AbbViePageInfo.campaignTracking.campaignMasterId  sa_payload.CampaignMasterId;					if(campaignTracking.getOptionID()){						// console.log(-- Option ID Found --);						if(campaignTracking.getQuestionID()){							// console.log(-- Question ID Found --);							saveReady  true;						}						campaignTracking.getAdditionalInfo();					}				}			}			if(saveReady){				campaignTracking.saveAssessment();			}		},		getIndividualID : function (){			let haveInfo  false;			if(urlObj.getParam(s_fid,false) ! undefined){				gpf_payload.Source  Intouch;				gpf_payload.FulfillmentID  urlObj.getParam(s_fid,false);				haveInfo  true;				// return true;			} else if (urlObj.getParam(h_fid,false) ! undefined){				gpf_payload.Source  Epsilon;				gpf_payload.FulfillmentID  urlObj.getParam(h_fid,false);				haveInfo  true;				// return true;			} else if (urlObj.getParam(fid) ! undefined){				gpf_payload.Source  Epsilon;				gpf_payload.FulfillmentID  urlObj.getParam(fid,false);				haveInfo  true;				// return true;			} else {				console.log(missing fid variant);				// return false;			}			if(haveInfo){				//Ajax call to get individual ID				let url  AbbViePageInfo.apiEndPoints.getPatientFullfilment;				let successState  false;				ajaxCall(url, POST, JSON.stringify(gpf_payload), gpfSuccess, gpfFail);				//Success				function gpfSuccess(data){					//Set to sa_payload					if(data.ContentResult && data.ContentResult.IndividualId){						var id  data.ContentResult.IndividualId;						sa_payload.IndividualId  id;						sessionStorage.setItem(IndividualId,id);						//Write cookie						successState  true;					}				}				//Fail				function gpfFail(jqXHR, textStatus, errorThrown){					//return false					console.log(Get Patient Fullfillment Fail);					successState  false;				}				return successState;			} else {				return false;			}		},		getCampaignMasterID : function(){			if(urlObj.getParam(mcid,false) ! undefined){				sa_payload.CampaignMasterId  urlObj.getParam(mcid,false);				return true;			} else if (urlObj.getParam(em_id) ! undefined){				sa_payload.CampaignMasterId  idTables.emidsurlObj.getParam(em_id);				questionLookupReq  true;				return true;			} else if (urlObj.getParam(sid) ! undefined){				sa_payload.CampaignMasterId  idTables.sidsurlObj.getParam(sid);				questionLookupReq  true;				return true;			} else if (urlObj.getParam(qID) ! undefined){				sa_payload.CampaignMasterId  idTables.qidsurlObj.getParam(qID);				questionLookupReq  true;				return true;			} else if (urlObj.getParam(eid) ! undefined){				sa_payload.CampaignMasterId  idTables.eidsurlObj.getParam(eid);				questionLookupReq  true;				return true;			} else {				console.log(missing master campaign id in query or corresponding id);				return false;			}		},		getQuestionID : function(){			if(questionLookupReq){				// console.log(Question Id lookup Required);				let successState  false;				let cmi_query  ?CampaignMasterId+sa_payload.CampaignMasterId;				let url  AbbViePageInfo.apiEndPoints.getAssessment+cmi_query;				ajaxCall(url, GET, , getAssessmentSuccess, getAssessmentFail);				function getAssessmentSuccess(data){					// console.log(getAssessmentSuccess);					if(data.IsStatusSuccessful  true){						var matchOption  sa_payload.AssessmentQuestion0.QuestionOptions0.OptionId;						var questionList  data.ContentResult.AssessmentQuestion;						var matchedQuestionID  campaignTracking.reverseLookup(questionList, matchOption);						if(matchedQuestionID ! undefined){							sa_payload.AssessmentQuestion0.QuestionId  matchedQuestionID;							successState  true;							// console.log(reverse lookup found question id);						} else { console.log(no option id matching in campaign);}					} else {						console.warn(getAssessment status successful  false);					}				}				function getAssessmentFail(jqXHR, textStatus, errorThrown){console.log(getAssessmentFail);}				return successState;			} else {				if(urlObj.getParam(qid) ! undefined){					sa_payload.AssessmentQuestion0.QuestionId  urlObj.getParam(qid);					return true;				}				else {					console.log(missing question id in query or corresponding id);					return false;				}			}		},		getOptionID : function(){			if(urlObj.getParam(oid,false) ! undefined){				sa_payload.AssessmentQuestion0.QuestionOptions0.OptionId  urlObj.getParam(oid,false);				return true;			} else if (urlObj.getParam(eid) ! undefined){				if(urlObj.getParam(qid) ! undefined){					let lookup  urlObj.getParam(eid) + urlObj.getParam(qid);					if(idTables.optionidslookup ! 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undefined) {        payload.brandName  AbbViePageInfo.brandConfig;    }    var refreshToken_api_url  AbbViePageInfo.apiEndPoints.refreshToken;    console.log(Inside  refresh login : brandAPIRefreshLogin + refreshToken_api_url);    ajaxCall(refreshToken_api_url, POST, JSON.stringify(payload), onSuccessTokenCall, onFailedTokenCall, true);    function onSuccessTokenCall(data) {        if (data.IsStatusSuccessful) {            var newToken  data.ContentResult ||data.admp_login_token ;            cookieObj.createCookie(admp_login_token, newToken, 15 / 1440);            cookieObj.createCookie(HID, newToken, 15 / 1440);        } else {            console.log(Failed to update tokens);        }    }    function onFailedTokenCall() {        console.log(Failed to update tokens);    }}function apigeeAPIRefreshLogin(cookieCheck) {    var payload  {        admp_login_token: cookieCheck        };    if (AbbViePageInfo.brandConfig ! undefined) {        payload.brandName  AbbViePageInfo.brandConfig;    }    var refreshToken_api_url  AbbViePageInfo.apiEndPoints.refreshToken;    console.log(Inside apigee refresh login  + refreshToken_api_url);    ajaxCall(refreshToken_api_url, POST, JSON.stringify(payload), onSuccessTokenCall, onFailedTokenCall, true);    function onSuccessTokenCall(response) {        var refreshLoginResp  JSON.parse(response.admp_login_token);        if (refreshLoginResp.RefreshTokenResponse.IsStatusSuccessful  true) {            cookieObj.createCookie(admp_login_token, refreshLoginResp.RefreshTokenResponse.TokenDetails0.RefreshToken, response.cookie_age/60/60/24, response.cookie_seccure_flag false);        } else {             console.log(Failed to update tokens in APIGEE);        }    }    function onFailedTokenCall() {        console.log(Failed to update tokens IN APIGEE);    }}function setHeaders(url, xhr){	xhr.setRequestHeader(content-type,application/json);	// If call is a save assessment call	if(AbbViePageInfo.apiEndPoints.saveAssessment  url){		let acMcIdCookie  cookieObj.getCookie(ac_mcid);		if(acMcIdCookie ! 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https://www.rxabbvie.com/pdf/humira.pdf,            warning: Important Safety Information., SERIOUS INFECTIONS, Patients treated with HUMIRA are at increased risk for developing serious infections that may lead to hospitalization or death. Most patients who developed these infections were taking concomitant immunosuppressants such as methotrexate or corticosteroids., Discontinue HUMIRA if a patient develops a serious infection or sepsis., Reported infections include:, Active tuberculosis (TB), including reactivation of latent TB. Patients with TB have frequently presented with disseminated or extrapulmonary disease. Test patients for latent TB before HUMIRA use and during therapy. Initiate treatment for latent TB prior to HUMIRA use., Invasive fungal infections, including histoplasmosis, coccidioidomycosis, candidiasis, aspergillosis, blastomycosis, and pneumocystosis. Patients with histoplasmosis or other invasive fungal infections may present with disseminated, rather than localized, disease. Antigen and antibody testing for histoplasmosis may be negative in some patients with active infection. Consider empiric anti‑fungal therapy in patients at risk for invasive fungal infections who develop severe systemic illness., Bacterial, viral, and other infections due to opportunistic pathogens, including Legionella and Listeria., Carefully consider the risks and benefits of treatment with HUMIRA prior to initiating therapy in patients: 1. with chronic or recurrent infection, 2. who have been exposed to TB, 3. with a history of opportunistic infection, 4. who resided in or traveled in regions where mycoses are endemic, 5. with underlying conditions that may predispose them to infection. Monitor patients closely for the development of signs and symptoms of infection during and after treatment with HUMIRA, including the possible development of TB in patients who tested negative for latent TB infection prior to initiating therapy., Do not start HUMIRA during an active infection, including localized infections., Patients older than 65 years, patients with co‑morbid conditions, and/or patients taking concomitant immunosuppressants may be at greater risk of infection., If an infection develops, monitor carefully and initiate appropriate therapy., Drug interactions with biologic products: A higher rate of serious infections has been observed in RA patients treated with rituximab who received subsequent treatment with a TNF blocker. An increased risk of serious infections has been seen with the combination of TNF blockers with anakinra or abatacept, with no demonstrated added benefit in patients with RA. Concomitant administration of HUMIRA with other biologic DMARDs (e.g., anakinra or abatacept) or other TNF blockers is not recommended based on the possible increased risk for infections and other potential pharmacological interactions., MALIGNANCY, Lymphoma and other malignancies, some fatal, have been reported in children and adolescent patients treated with TNF blockers, including HUMIRA. Postmarketing cases of hepatosplenic T‑cell lymphoma (HSTCL), a rare type of T‑cell lymphoma, have been reported in patients treated with TNF blockers, including HUMIRA. These cases have had a very aggressive disease course and have been fatal. The majority of reported TNF blocker cases have occurred in patients with Crohns disease or ulcerative colitis and the majority were in adolescent and young adult males. Almost all of these patients had received treatment with azathioprine or 6‑mercaptopurine concomitantly with a TNF blocker at or prior to diagnosis. It is uncertain whether the occurrence of HSTCL is related to use of a TNF blocker or a TNF blocker in combination with these other immunosuppressants., Consider the risks and benefits of HUMIRA treatment prior to initiating or continuing therapy in a patient with known malignancy., In clinical trials, more cases of malignancies were observed among HUMIRA-treated patients compared to control patients., Non‑melanoma skin cancer (NMSC) was reported during clinical trials for HUMIRA‑treated patients. Examine all patients, particularly those with a history of prolonged immunosuppressant or PUVA therapy, for the presence of NMSC prior to and during treatment with HUMIRA., In HUMIRA clinical trials, there was an approximate 3‑fold higher rate of lymphoma than expected in the general U.S. population. Patients with chronic inflammatory diseases, particularly those with highly active disease and/or chronic exposure to immunosuppressant therapies, may be at higher risk of lymphoma than the general population, even in the absence of TNF blockers., Postmarketing cases of acute and chronic leukemia were reported with TNF blocker use. Approximately half of the postmarketing cases of malignancies in children, adolescents, and young adults receiving TNF blockers were lymphomas; other cases included rare malignancies associated with immunosuppression and malignancies not usually observed in children and adolescents., HYPERSENSITIVITY, Anaphylaxis and angioneurotic edema have been reported following HUMIRA administration. If a serious allergic reaction occurs, stop HUMIRA and institute appropriate therapy., HEPATITIS B VIRUS REACTIVATION, Use of TNF blockers, including HUMIRA, may increase the risk of reactivation of hepatitis B virus (HBV) in patients who are chronic carriers. Some cases have been fatal., Evaluate patients at risk for HBV infection for prior evidence of HBV infection before initiating TNF blocker therapy., Exercise caution in patients who are carriers of HBV and monitor them during and after HUMIRA treatment., Discontinue HUMIRA and begin antiviral therapy in patients who develop HBV reactivation. Exercise caution when resuming HUMIRA after HBV treatment., NEUROLOGIC REACTIONS, TNF blockers, including HUMIRA, have been associated with rare cases of new onset or exacerbation of central nervous system and peripheral demyelinating diseases, including multiple sclerosis, optic neuritis, and Guillain‑Barré syndrome., Exercise caution when considering HUMIRA for patients with these disorders; discontinuation of HUMIRA should be considered if any of these disorders develop., There is a known association between intermediate uveitis and central demyelinating disorders., HEMATOLOGIC REACTIONS, Rare reports of pancytopenia, including aplastic anemia, have been reported with TNF blockers. Medically significant cytopenia has been infrequently reported with HUMIRA., Consider stopping HUMIRA if significant hematologic abnormalities occur., CONGESTIVE HEART FAILURE, Worsening and new onset congestive heart failure (CHF) has been reported with TNF blockers. Cases of worsening CHF have been observed with HUMIRA; exercise caution and monitor carefully., AUTOIMMUNITY, Treatment with HUMIRA may result in the formation of autoantibodies and, rarely, in development of a lupus‑like syndrome. Discontinue treatment if symptoms of a lupus‑like syndrome develop., IMMUNIZATIONS, Patients on HUMIRA should not receive live vaccines., Pediatric patients, if possible, should be brought up to date with all immunizations before initiating HUMIRA therapy., Adalimumab is actively transferred across the placenta during the third trimester of pregnancy and may affect immune response in the in utero exposed infant. The safety of administering live or live‑attenuated vaccines in infants exposed to HUMIRA in utero is unknown. 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Spondyloarthritis,type:external,url:https://www.rinvoqhcp.com/axspa},component:{type:content,l10title:,title:Rinvoq: Rheumatology,name:CTA,position:content},content:{},interaction:{type:,name:Non-radiographic Axial Spondyloarthritis,id:abbv-cta-894147490},menu:{}}}} class    abbv-button-plain  brandexplorer__indication brandexplorer__indication--active  rolelink aria-labelNon-radiographic Axial Spondyloarthritis hrefhttps://www.rinvoqhcp.com/axspa target_self data-linktypeexternal aria-hiddenfalse>Non-radiographic Axial Spondyloarthritis/a>                                                    /div>            div classcta parbase>                                                                        	a data-digitaldata{digitalData:{page:{link:{name:Atopic Dermatitis,displayTitle:Atopic Dermatitis,type:external,url:https://www.rinvoqhcp.com/atopic-dermatitis},component:{type:content,l10title:,title:Rinvoq: Dermatology,name:CTA,position:content},content:{},interaction:{type:,name:Atopic 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Therapies tabindex0 target_self data-linktypeinternal aria-hiddenfalse>Immunology Therapies/a>                                                    /div>    /div>        /div>            div classcontainer parbase>    div classabbv-container brandexplorer__right>                    div classcta parbase>                                                                        	a data-digitaldata{digitalData:{page:{link:{name:,displayTitle:Contact Medical Info,type:internal,url:abbvModalExitContactMedicalInfo},component:{type:content,l10title:,title:,name:CTA,position:content},content:{},interaction:{type:,name:Contact Medical Info,id:abbv-cta-1678518780},menu:{}}}} classabbv-modal-open    abbv-button-plain    data-idabbvModalExitContactMedicalInfo rolelink aria-labelContact Medical Info, Opens in a new modal tabindex0 targetnew-modal data-linktypeinternal aria-hiddenfalse>Contact Medical Info/a>                                                    /div>            div classcta parbase>                                                                        	a data-digitaldata{digitalData:{page:{link:{name:,displayTitle:Full Prescribing Information,type:internal,url:/prescribinginfo},component:{type:content,l10title:,title:,name:CTA,position:content},content:{},interaction:{type:,name:Full Prescribing Information,id:abbv-cta-519277934},mva:{name:,tier:secondary,type:Download,category:Prescribing Information},menu:{}}}} class    abbv-button-plain    rolelink aria-labelFull Prescribing Information, Opens in a new window href/prescribinginfo target_blank data-linktypeinternal aria-hiddenfalse>Full Prescribing Information/a>                                                    /div>            div classcta parbase>                                                                        	a data-digitaldata{digitalData:{page:{link:{name:,displayTitle:Patient Site,type:internal,url:/patientsite},component:{type:content,l10title:,title:,name:CTA,position:content},content:{},interaction:{type:,name:Patient Site,id:abbv-cta-255183296},menu:{}}}} class    abbv-button-plain    rolelink aria-labelPatient Site, Opens in a new window href/patientsite target_blank data-linktypeinternal aria-hiddenfalse>Patient Site/a>                                                    /div>    /div>        /div>    /div>        /div>            div classhtml-container>!--/* Begin: AbbVie Embed Pro Component */ -->div classabbv-html-container abbv-embed-pro >	script>document.addEventListener(DOMContentLoaded, function(event) {  /* Immunology Therapies Button   - On click adds the open class and slide toggles the content */  $(.brandexplorer__browse).click(function(){    $(.brandexplorer).toggleClass(brandexplorer__open);    $(.brandexplorer__content).slideToggle();  });  /* Close Button   - On click removes the open class and slide toggles the content */  $(.brandexplorer__close).click(function(){    $(.brandexplorer).toggleClass(brandexplorer__open);    $(.brandexplorer__content).slideToggle();  });  /* Close on outside click   - On click removes the open class and slide toggles the content */  $(document).click(function(e){    var container  $(.brandexplorer);    // if the target of the click isnt the container nor a descendant of the container    if (!container.is(e.target) && container.has(e.target).length  0) {      if($(.brandexplorer).hasClass(brandexplorer__open)){        $(.brandexplorer).toggleClass(brandexplorer__open);        $(.brandexplorer__content).slideToggle();      }    }  });  /* Accordion Blade   - On click adds the active class to the parent container   -  and slide toggles the content and open accordions   - collapses the current blade if open */  $(.brandexplorer__blade).click(function(){  if($(window).width() 896) {    var prnt  $(this).parent().parent();     $(.brandexplorer__accordion).each(function() {      if($(this).is(prnt)) {        $(this).toggleClass(brandexplorer__active);        $(this).find(.brandexplorer__links).slideToggle();      } else {        $(this).removeClass(brandexplorer__active);        $(this).find(.brandexplorer__links).slideUp();      }    });  }  }); });/script>/div>/div>    /div>        /div>/div>/div>                            div classnewpar new section>/div>                            div classpar iparys_inherited>                /div>        		div classabbv-content-container data-anim-top0 data-anim-btm0>				div>                            div classheader parbase>	header classabbv-header abbv-header-lite    abbv-indication-swap data-stick-offset0>    div classabbv-header-utility-navigation abbv-navigation>        ul>            li>                                                                                          				a data-digitaldata{digitalData:{page:{component:{l10title:,name:Utility Navigation,position:header,type:menu,title:Request a Field Access Specialist},link:{displayTitle:Field Access SpecialistWith expertise in insurance plan processes,name:Request a Field Access Specialist,type:internal,url:/content/humirapro/en-us/request-a-specialist},interaction:{name:Field Access SpecialistWith expertise in insurance plan processes,id:abbv-utilitynavigation-1513166222-0,type:menu,tags:},mva:{tier:secondary,name:Resource Request A Specialist,type:Link,category:Register for Service},menu:{level:1},content:{name:,type:,title:}}}} rolemenuitem class    i-a nav-tier1   header__utility--cta fas href/request-a-specialist target_self data-linktypeinternal>Field Access Specialistspan>With expertise in insurance plan processes/span>/a>	                                                   /li>        /ul>    /div>        div classabbv-header-content-container>        div classabbv-header-content >            div classabbv-header-left>                    																a data-digitaldata{digitalData:{page:{component:{l10title:,name:Logo,position:header,type:link,title:},link:{displayTitle:,name:,type:internal,url:/},interaction:{name:,id:abbv-logo-1440537542-1,type:link,tags:},mva:{},menu:{},content:{name:,type:,title:}}}} href/ target_self data-linktypeinternal>							img altHUMIRA® (adalimumab). src/content/dam/humirapro/images/header-logo.svg/>/img>								/a>								            /div>            div classabbv-header-right>                								div classabbv-header-mobile-primary-navigation tabindex0 aria-labelnavigation menu rolebutton aria-expandedfalse>                    span classline>/span>                    span classline>/span>                    span classline>/span>                /div>            /div>        /div>        		        div classabbv-header-primary-navigation abbv-navigation>	          ul>                li>                    																	a data-digitaldata{digitalData:{page:{component:{l10title:,name:Logo,position:header,type:link,title:},link:{displayTitle:,name:,type:internal,url:/},interaction:{name:,id:abbv-logo-1440537542-1,type:link,tags:},mva:{},menu:{},content:{name:,type:,title:}}}} classabbv-header-lite-logo-inline   href/ target_self data-linktypeinternal>							img altHUMIRA® (adalimumab). src/content/dam/humirapro/images/header-logo.svg/>/img>								/a>								                /li>                									li>         /li>									li>                                                   				a data-digitaldata{digitalData:{page:{component:{l10title:,name:Primary Navigation,position:header,type:menu,title:Home},link:{displayTitle:Home,name:Home,type:internal,url:/},interaction:{name:Home,id:abbv-primarynavigation-570296823,type:menu,tags:},mva:{},menu:{level:1},content:{name:,type:,title:}}}} rolemenuitem relnofollow class       abbv-nav-active href/ target_self>Home/a>	                     /li>									li>                                                      				a data-digitaldata{digitalData:{page:{component:{l10title:,name:Primary Navigation,position:header,type:menu,title:Clinical Profile},link:{displayTitle:Clinical Profile,name:Clinical Profile,type:internal,url:},interaction:{name:Clinical Profile,id:abbv-primarynavigation-570296822,type:menu,tags:},mva:{},menu:{level:1},content:{name:,type:,title:}}}} rolemenuitem relnofollow aria-labelcollapsed Clinical Profile aria-expandedfalse class abbv-has-submenu        href# target_self>Clinical Profile/a>	                  span aria-hiddentrue>i>/i>/span>            div classabbv-header-primary-navigation-submenu abbv-submenu>                     ul rolemenu>                                 li rolenone classabbv-header-primary-navigation-submenu-title >                                                                                                                        					a data-digitaldata{digitalData:{page:{component:{l10title:,name:Primary Navigation,position:header,type:menu,title:Clinical Profile},link:{displayTitle:Rheumatology,name:Rheumotology,type:internal,url:},interaction:{name:Rheumatology,id:abbv-primarynavigation-570296822-0,type:menu,tags:},mva:{},menu:{level:2},content:{name:,type:,title:}}}} class  abbv-icon-keyboard_arrow_right i-a  rolemenuitem href# target_self>Rheumatology/a>	                                                               /li>                                                                                          li rolenone classcontent_moderate-to-severe>                                                                                                            					a data-digitaldata{digitalData:{page:{component:{l10title:,name:Primary Navigation,position:header,type:menu,title:Clinical Profile},link:{displayTitle:Rheumatoid Arthritis,name:Rheumatology: Rheumatoid Arthritis,type:internal,url:/content/humirapro/en-us/rheumatoid-arthritis},interaction:{name:Rheumatoid Arthritis,id:abbv-primarynavigation-570296822-00,type:menu,tags:},mva:{},menu:{level:2},content:{name:,type:,title:}}}} rolemenuitem href/rheumatoid-arthritis target_self>Rheumatoid Arthritis/a>	                                                                        /li>                                                                                             li rolenone classcontent_active>                                                                                                            					a data-digitaldata{digitalData:{page:{component:{l10title:,name:Primary Navigation,position:header,type:menu,title:Clinical Profile},link:{displayTitle:Psoriatic Arthritis,name:Rheumatology: Psoriatic Arthritis,type:internal,url:/content/humirapro/en-us/psoriatic-arthritis},interaction:{name:Psoriatic Arthritis,id:abbv-primarynavigation-570296822-01,type:menu,tags:},mva:{},menu:{level:2},content:{name:,type:,title:}}}} rolemenuitem href/psoriatic-arthritis target_self>Psoriatic Arthritis/a>	                                                                        /li>                                                                                             li rolenone classcontent_active>                                                                                                            					a data-digitaldata{digitalData:{page:{component:{l10title:,name:Primary Navigation,position:header,type:menu,title:Clinical Profile},link:{displayTitle:Ankylosing Spondylitis,name:Rheumatology: Ankylosing Spondylitis,type:internal,url:/content/humirapro/en-us/ankylosing-spondylitis},interaction:{name:Ankylosing Spondylitis,id:abbv-primarynavigation-570296822-02,type:menu,tags:},mva:{},menu:{level:2},content:{name:,type:,title:}}}} rolemenuitem href/ankylosing-spondylitis target_self>Ankylosing Spondylitis/a>	                                                                        /li>                                                                                             li rolenone classcontent_moderate-to-severe>                                                                                                            					a data-digitaldata{digitalData:{page:{component:{l10title:,name:Primary Navigation,position:header,type:menu,title:Clinical Profile},link:{displayTitle:Juvenile Idiopathic Arthritis,name:Rheumatology: Juvenile Idiopathic Arthritis,type:internal,url:/content/humirapro/en-us/jia},interaction:{name:Juvenile Idiopathic Arthritis,id:abbv-primarynavigation-570296822-03,type:menu,tags:},mva:{},menu:{level:2},content:{name:,type:,title:}}}} rolemenuitem href/jia target_self>Juvenile Idiopathic Arthritis/a>	                                                                        /li>                                                                                             li rolenone classcontent_non-infectious>                                                                                                            					a data-digitaldata{digitalData:{page:{component:{l10title:,name:Primary Navigation,position:header,type:menu,title:Clinical Profile},link:{displayTitle:Uveitis (Adult),name:Rheumatology: Uveitis (Adult),type:internal,url:/content/humirapro/en-us/uveitis},interaction:{name:Uveitis (Adult),id:abbv-primarynavigation-570296822-04,type:menu,tags:},mva:{},menu:{level:2},content:{name:,type:,title:}}}} rolemenuitem href/uveitis target_self>Uveitis (Adult)/a>	                                                                        /li>                                                                                             li rolenone classcontent_non-infectious>                                                                                                            					a data-digitaldata{digitalData:{page:{component:{l10title:,name:Primary Navigation,position:header,type:menu,title:Clinical Profile},link:{displayTitle:Pediatric Uveitis,name:Rheumatology: Pediatric Uveitis,type:internal,url:/content/humirapro/en-us/uveitis-pediatric},interaction:{name:Pediatric Uveitis,id:abbv-primarynavigation-570296822-05,type:menu,tags:},mva:{},menu:{level:2},content:{name:,type:,title:}}}} rolemenuitem href/uveitis-pediatric target_self>Pediatric Uveitis/a>	                                                                        /li>                                             /ul>                     ul rolemenu>                                 li rolenone classabbv-header-primary-navigation-submenu-title >                                                                                                                        					a data-digitaldata{digitalData:{page:{component:{l10title:,name:Primary Navigation,position:header,type:menu,title:Clinical Profile},link:{displayTitle:Dermatology,name:Dermatology,type:internal,url:},interaction:{name:Dermatology,id:abbv-primarynavigation-570296822-1,type:menu,tags:},mva:{},menu:{level:2},content:{name:,type:,title:}}}} class  abbv-icon-keyboard_arrow_right i-a  rolemenuitem href# target_self>Dermatology/a>	                                                               /li>                                                                                          li rolenone classcontent_moderate-to-severe>                                                                                                            					a data-digitaldata{digitalData:{page:{component:{l10title:,name:Primary Navigation,position:header,type:menu,title:Clinical Profile},link:{displayTitle:Chronic Plaque Psoriasis,name:Dermatology: Chronic Plaque Psoriasis,type:internal,url:/content/humirapro/en-us/plaque-psoriasis},interaction:{name:Chronic Plaque Psoriasis,id:abbv-primarynavigation-570296822-10,type:menu,tags:},mva:{},menu:{level:2},content:{name:,type:,title:}}}} rolemenuitem href/plaque-psoriasis target_self>Chronic Plaque Psoriasis/a>	                                                                        /li>                                                                                             li rolenone classcontent_active>                                                                                                            					a data-digitaldata{digitalData:{page:{component:{l10title:,name:Primary Navigation,position:header,type:menu,title:Clinical Profile},link:{displayTitle:Psoriatic Arthritis,name:Dermatology: Psoriatic Arthritis,type:internal,url:/content/humirapro/en-us/psoriatic-arthritis},interaction:{name:Psoriatic Arthritis,id:abbv-primarynavigation-570296822-11,type:menu,tags:},mva:{},menu:{level:2},content:{name:,type:,title:}}}} rolemenuitem href/psoriatic-arthritis target_self>Psoriatic Arthritis/a>	                                                                        /li>                                                                                             li rolenone classcontent_moderate-to-severe>                                                                                                            					a data-digitaldata{digitalData:{page:{component:{l10title:,name:Primary Navigation,position:header,type:menu,title:Clinical Profile},link:{displayTitle:Hidradenitis Suppurativa,name:Dermatology: Hidradenitis Suppurativa,type:internal,url:/content/humirapro/en-us/hidradenitis-suppurativa},interaction:{name:Hidradenitis Suppurativa,id:abbv-primarynavigation-570296822-12,type:menu,tags:},mva:{},menu:{level:2},content:{name:,type:,title:}}}} rolemenuitem href/hidradenitis-suppurativa target_self>Hidradenitis Suppurativa/a>	                                                                        /li>                                             /ul>                     ul rolemenu>                                 li rolenone classabbv-header-primary-navigation-submenu-title >                                                                                                                        					a data-digitaldata{digitalData:{page:{component:{l10title:,name:Primary Navigation,position:header,type:menu,title:Clinical Profile},link:{displayTitle:Gastroenterology,name:Gastroenterology: Gastroenterology,type:internal,url:},interaction:{name:Gastroenterology,id:abbv-primarynavigation-570296822-2,type:menu,tags:},mva:{},menu:{level:2},content:{name:,type:,title:}}}} class  abbv-icon-keyboard_arrow_right i-a  rolemenuitem href# target_self>Gastroenterology/a>	                                                               /li>                                                                                          li rolenone classcontent_moderate-to-severe>                                                                                                            					a data-digitaldata{digitalData:{page:{component:{l10title:,name:Primary Navigation,position:header,type:menu,title:Clinical Profile},link:{displayTitle:Crohn\u2019s Disease (Adult),name:Gastroenterology: Crohns Disease (Adult),type:internal,url:/content/humirapro/en-us/crohns-disease},interaction:{name:Crohn\u2019s Disease (Adult),id:abbv-primarynavigation-570296822-20,type:menu,tags:},mva:{},menu:{level:2},content:{name:,type:,title:}}}} rolemenuitem href/crohns-disease target_self>Crohn’s Disease (Adult)/a>	                                                                        /li>                                                                                             li rolenone classcontent_moderate-to-severe>                                                                                                            					a data-digitaldata{digitalData:{page:{component:{l10title:,name:Primary Navigation,position:header,type:menu,title:Clinical Profile},link:{displayTitle:Pediatric Crohn\u2019s Disease,name:Gastroenterology: Pediatric Crohns Disease,type:internal,url:/content/humirapro/en-us/pediatric-crohns-disease},interaction:{name:Pediatric Crohn\u2019s Disease,id:abbv-primarynavigation-570296822-21,type:menu,tags:},mva:{},menu:{level:2},content:{name:,type:,title:}}}} rolemenuitem href/pediatric-crohns-disease target_self>Pediatric Crohn’s Disease/a>	                                                                        /li>                                                                                             li rolenone classcontent_moderate-to-severe>                                                                                                            					a data-digitaldata{digitalData:{page:{component:{l10title:,name:Primary Navigation,position:header,type:menu,title:Clinical Profile},link:{displayTitle:Ulcerative Colitis (Adult),name:Gastroenterology: Ulcerative Colitis (Adult),type:internal,url:/content/humirapro/en-us/ulcerative-colitis},interaction:{name:Ulcerative Colitis (Adult),id:abbv-primarynavigation-570296822-22,type:menu,tags:},mva:{},menu:{level:2},content:{name:,type:,title:}}}} rolemenuitem href/ulcerative-colitis target_self>Ulcerative Colitis (Adult)/a>	                                                                        /li>                                                                                             li rolenone classcontent_moderate-to-severe>                                                                                                            					a data-digitaldata{digitalData:{page:{component:{l10title:,name:Primary Navigation,position:header,type:menu,title:Clinical Profile},link:{displayTitle:Pediatric Ulcerative Colitis,name:Gastroenterology: Pediatric Ulcerative Colitis,type:internal,url:/content/humirapro/en-us/pediatric-ulcerative-colitis},interaction:{name:Pediatric Ulcerative Colitis,id:abbv-primarynavigation-570296822-23,type:menu,tags:},mva:{},menu:{level:2},content:{name:,type:,title:}}}} rolemenuitem href/pediatric-ulcerative-colitis target_self>Pediatric Ulcerative Colitis/a>	                                                                        /li>                                             /ul>                     ul rolemenu>                                 li rolenone classabbv-header-primary-navigation-submenu-title >                                                                                                                        					a data-digitaldata{digitalData:{page:{component:{l10title:,name:Primary Navigation,position:header,type:menu,title:Clinical Profile},link:{displayTitle:Ophthalmology,name:Ophthalmology,type:internal,url:},interaction:{name:Ophthalmology,id:abbv-primarynavigation-570296822-3,type:menu,tags:},mva:{},menu:{level:2},content:{name:,type:,title:}}}} class  abbv-icon-keyboard_arrow_right i-a  rolemenuitem href# target_self>Ophthalmology/a>	                                                               /li>                                                                                          li rolenone classcontent_non-infectious>                                                                                                            					a data-digitaldata{digitalData:{page:{component:{l10title:,name:Primary Navigation,position:header,type:menu,title:Clinical Profile},link:{displayTitle:Uveitis (Adult),name:Ophthalmology: Uveitis (Adult),type:internal,url:/content/humirapro/en-us/uveitis},interaction:{name:Uveitis (Adult),id:abbv-primarynavigation-570296822-30,type:menu,tags:},mva:{},menu:{level:2},content:{name:,type:,title:}}}} rolemenuitem href/uveitis target_self>Uveitis (Adult)/a>	                                                                        /li>                                                                                             li rolenone classcontent_non-infectious>                                                                                                            					a data-digitaldata{digitalData:{page:{component:{l10title:,name:Primary Navigation,position:header,type:menu,title:Clinical Profile},link:{displayTitle:Pediatric Uveitis,name:Ophthalmology: Pediatric Uveitis,type:internal,url:/content/humirapro/en-us/uveitis-pediatric.html},interaction:{name:Pediatric Uveitis,id:abbv-primarynavigation-570296822-31,type:menu,tags:},mva:{},menu:{level:2},content:{name:,type:,title:}}}} rolemenuitem href/uveitis-pediatric target_self>Pediatric Uveitis/a>	                                                                        /li>                                             /ul>               /div>   /li>									li>                                                   				a data-digitaldata{digitalData:{page:{component:{l10title:,name:Primary Navigation,position:header,type:menu,title:Dosing},link:{displayTitle:Dosing,name:Dosing,type:internal,url:/content/humirapro/en-us/dosing},interaction:{name:Dosing,id:abbv-primarynavigation-570296821,type:menu,tags:},mva:{},menu:{level:1},content:{name:,type:,title:}}}} rolemenuitem relnofollow href/dosing target_self>Dosing/a>	                     /li>									li>                                                   				a data-digitaldata{digitalData:{page:{component:{l10title:,name:Primary Navigation,position:header,type:menu,title:Safety},link:{displayTitle:Safety,name:Safety,type:internal,url:/content/humirapro/en-us/global-safety},interaction:{name:Safety,id:abbv-primarynavigation-570296820,type:menu,tags:},mva:{},menu:{level:1},content:{name:,type:,title:}}}} rolemenuitem relnofollow class   dosing-and-monitoring-menu     href/global-safety target_self>Safety/a>	                     /li>									li>                                                   				a data-digitaldata{digitalData:{page:{component:{l10title:,name:Primary Navigation,position:header,type:menu,title:Patient Support},link:{displayTitle:Patient Support,name:Patient Support,type:internal,url:/content/humirapro/en-us/patient-support},interaction:{name:Patient Support,id:abbv-primarynavigation-570296819,type:menu,tags:},mva:{},menu:{level:1},content:{name:,type:,title:}}}} rolemenuitem relnofollow class   dosing-and-monitoring-menu     href/patient-support target_self>Patient Support/a>	                     /li>									li>                                                   				a data-digitaldata{digitalData:{page:{component:{l10title:,name:Primary Navigation,position:header,type:menu,title:About HUMIRA},link:{displayTitle:About HUMIRA,name:About HUMIRA,type:internal,url:/content/humirapro/en-us/about-humira},interaction:{name:About HUMIRA,id:abbv-primarynavigation-570296818,type:menu,tags:},mva:{},menu:{level:1},content:{name:,type:,title:}}}} rolemenuitem relnofollow href/about-humira target_self>About HUMIRA/a>	                     /li>									li>                                                   				a data-digitaldata{digitalData:{page:{component:{l10title:,name:Primary Navigation,position:header,type:menu,title:Field Access Specialist},link:{displayTitle:Field Access Specialist,name:Field Access Specialist,type:internal,url:/content/humirapro/en-us/request-a-specialist},interaction:{name:Field Access Specialist,id:abbv-primarynavigation-570296817,type:menu,tags:},mva:{},menu:{level:1},content:{name:,type:,title:}}}} rolemenuitem relnofollow class   fas-mobile-cta     href/request-a-specialist target_self>Field Access Specialist/a>	                     /li>						                        li classabbv-search-inline>               			span classabbv-search-toggle rolebutton tabindex0 aria-expandedfalse aria-labelSearch>i classabbv-icon-search i-a>/i>/span>	div classabbv-search-navigation>		div classabbv-search-input-container>						a aria-hiddentrue styledisplay:none href/search-results>/a>			input aria-expandedtrue idheader-search tabindex0 typetext maxlength100 value aria-labelSearch placeholderSearch classabbv-search  data-suggest-toggleno data-results-page data-max-suggestions0 data-char-trigger0/>			em aria-labelSearch tabindex0 rolebutton classabbv-icon-search i-a>/em>			div classabbv-search-suggestions styledisplay: none;>				ul>				/ul>			/div>		/div>	/div>                /li>                                            /ul>        /div>    /div>    /header>/div>                            div classnewpar new section>/div>                            div classpar iparys_inherited>                /div>    /div>				section rolemain>            div classbackground-container parbase>			    	    			div>	 			    div classabbv-background-container abbv-background-container-content-abbv-content-block-below marquee-background-container marquee-background-container_home idbackground-container-244389776>        div classabbv-background-container-display abbv-background-container-image-bg        			  stylebackground-image: url(/content/dam/humirapro/images/marquees/home-marquee.jpg)>/div>        div classabbv-background-container-content>            div>/div>            div classabbv-clear>/div>            			    div classabbv-background-container-content-block middle-left abbv-background-container-content-block-medium stylebackground: rgba(192, 192, 192, 0.0);>        div classabbv-background-container-content-block-display abbv-rich-text-common>            h1>A foundation of therapeutic disease management many patients need/h1>														        /div>    /div>        /div>    /div>		/div>	    	    	    	    	/div>            div classbackground-container parbase>			    	div> 			    div classabbv-background-container  background_eggshell idbackground-container-1598042924>        div classabbv-background-container-display           			 >/div>        div classabbv-background-container-content>            div>            div classcontainer parbase>    div classabbv-container container-body section-break>                    div classflexbox parbase>			        		div classabbv-flex-container two-column-charts          >							                					div classabbv-flex-item     >                    div classcontainer parbase>    div classabbv-container card-container card-container--home>                    div classcontainer parbase>    div classabbv-container card-container-header>                    div classimage-text parbase>    style>                .abbv-image-text-v1-610579971-large {                        display: inline-block;                    }    /style>!-- Begin: AbbVie Image + Text Component -->div classabbv-image-text card-container-image>            div classabbv-image-content-container   i-b>            img src/content/dam/humirapro/images/icons/icon-complete.svg classabbv-image-text-img abbv-image-text-v1-610579971-large altHUMIRA Complete logo./>        /div>                        /div>!-- End: AbbVie Image + Text Component -->/div>            div classrich-text>        div classabbv-rich-text card-container-title abbv-rich-text-common>        h4>HUMIRA Complete/h4>p>Learn how HUMIRA Complete can help your patients start and stay on track with their prescribed treatment plan./p>    /div>/div>            div classcta parbase>                                                                        	a data-digitaldata{digitalData:{page:{link:{name:Get Details,displayTitle:Get Details,type:internal,url:/content/humirapro/en-us/patient-support},component:{type:content,l10title:,title:HUMIRA Complete,name:CTA,position:content},content:{},interaction:{type:,name:Get Details,id:abbv-cta-1038421244},menu:{}}}} class    abbv-button-primary    rolelink aria-labelGet Details href/patient-support target_self data-linktypeinternal aria-hiddenfalse>Get Details/a>                                                    /div>    /div>        /div>    /div>        /div>/div>                							                					div classabbv-flex-item     >                    div classcontainer parbase>    div classabbv-container card-container card-container--home>                    div classcontainer parbase>    div classabbv-container card-container-header>                    div classimage-text parbase>    style>                .abbv-image-text-v1-1454773428-large {                        display: inline-block;                    }    /style>!-- Begin: AbbVie Image + Text Component -->div classabbv-image-text card-container-image>            div classabbv-image-content-container   i-b>            img src/content/dam/humirapro/images/icons/icon-pen.svg classabbv-image-text-img abbv-image-text-v1-1454773428-large altPen icon./>        /div>                        /div>!-- End: AbbVie Image + Text Component -->/div>            div classrich-text>        div classabbv-rich-text card-container-title abbv-rich-text-common>        h4>Dosing Information/h4>p>Get the recommended HUMIRA dose regimen for each indication./p>    /div>/div>            div classcta parbase>                                                                        	a data-digitaldata{digitalData:{page:{link:{name:Learn More,displayTitle:Learn More,type:internal,url:/content/humirapro/en-us/dosing},component:{type:content,l10title:,title:Dosing Information,name:CTA,position:content},content:{},interaction:{type:,name:Learn More,id:abbv-cta-1861793837},menu:{}}}} class    abbv-button-primary    rolelink aria-labelLearn More href/dosing target_self data-linktypeinternal aria-hiddenfalse>Learn More/a>                                                    /div>    /div>        /div>    /div>        /div>/div>                							                					div classabbv-flex-item     >                    div classcontainer parbase>    div classabbv-container card-container card-container--home>                    div classcontainer parbase>    div classabbv-container card-container-header>                    div classimage-text parbase>    style>                .abbv-image-text-v1-1355138317-large {                        display: inline-block;                    }    /style>!-- Begin: AbbVie Image + Text Component -->div classabbv-image-text card-container-image>            div classabbv-image-content-container   i-b>            img src/content/dam/humirapro/images/icons/icon-cross.svg classabbv-image-text-img abbv-image-text-v1-1355138317-large altFirst aid icon./>        /div>                        /div>!-- End: AbbVie Image + Text Component -->/div>            div classrich-text>        div classabbv-rich-text card-container-title abbv-rich-text-common>        h4>Resources & Forms/h4>p>Find prescription and enrollment forms, patient support, and other helpful resources./p>    /div>/div>            div classcta parbase>                                                                        	a data-digitaldata{digitalData:{page:{link:{name:Find Now,displayTitle:Find Now,type:internal,url:/content/humirapro/en-us/patient-support},component:{type:content,l10title:,title:Resources \u0026 Forms,name:CTA,position:content},content:{},interaction:{type:,name:Find Now,id:abbv-cta-752978638},menu:{}}}} class    abbv-button-primary    rolelink aria-labelFind Now href/patient-support target_self data-linktypeinternal aria-hiddenfalse>Find Now/a>                                                    /div>    /div>        /div>    /div>        /div>/div>                					/div>	/div>    /div>        /div>/div>            div classabbv-clear>/div>                    /div>    /div>		/div>	    	    	    	    	    	    	/div>            div classbackground-container parbase>			    	    			div>	 			    div classabbv-background-container abbv-background-container-content-abbv-content-block-below marquee-background-container body-background-container idbackground-container-1244050292>        div classabbv-background-container-display abbv-background-container-image-bg        			  stylebackground-image: url(/content/dam/humirapro/images/marquees/home-subsection.jpg)>/div>        div classabbv-background-container-content>            div>/div>            div classabbv-clear>/div>            			    div classabbv-background-container-content-block middle-left abbv-background-container-content-block-medium stylebackground: rgba(0,0,0, 0.0);>        div classabbv-background-container-content-block-display abbv-rich-text-common>            h3>A commitment to patients and the immunology community/h3>p>HUMIRA has been treating patients worldwide for 2 decades and counting./p>																														a linkmd{type:internal,url:/content/humirapro/en-us/about-humira,title:About HUMIRA,component:{type:content,title:A commitment to patients and the immunology community,name:background-container,position:content},journey:{patient:,content:,message_bucket:}} class abbv-button-primary    href/about-humira titleAbout HUMIRA target_self data-linktypeinternal>About HUMIRA/a>															        /div>    /div>        /div>    /div>		/div>	    	    	    	    	/div>            div classbackground-container parbase>			    	div> 			    div classabbv-background-container  background_eggshell section-break idbackground-container-1103715064>        div classabbv-background-container-display           			 >/div>        div classabbv-background-container-content>            div>            div classcontainer parbase>    div classabbv-container container-body section-break>                    div classflexbox parbase>			        		div classabbv-flex-container multi-column          >							                					div classabbv-flex-item flex-center-content flex-center-content--align-top flex-center-content--home        >                    div classrich-text>    a idefficacy aria-hiddentrue>/a>    div classabbv-rich-text container abbv-rich-text-common>        h3>HUMIRAbr />Clinical Profile/h3>p>Choose a therapeutic area and indicationbr />to view efficacy and safety data./p>    /div>/div>/div>                							                					div classabbv-flex-item     >                    div classcontainer parbase>    div classabbv-container card-container>                    div classaccordion parbase>    div classabbv-accordion abbv-accordion-single  data-icon-openabbv-icon-add data-icon-closedabbv-icon-remove>        div classabbv-accordion-container>												            														div data-trigger-forabbv-accordion-blade-1 classabbv-accordion-blade abbv-accordion-blade-1 >						div classabbv-accordion-blade-content tabindex0 rolebutton aria-labelRheumatology aria-expandedfalse data-digitaldata{digitalData:{page:{link:{name:Rheumatology,displayTitle:Rheumatology,type:internal,url:},component:{type:content,l10title:,title:HUMIRA Clinical Profile,name:Accordion,position:content},content:{  type:,title:,name:},interaction:{type:Link,name:Rheumatology,id:abbv-accordion-455443886-1},mva:{name:,tier:,  type:,category:}}}}>														div classabbv-accordion-blade-text    aria-hiddentrue>Rheumatology/div>						/div>						div classabbv-accordion-blade-icon aria-hiddentrue data-digitaldata{digitalData:{page:{link:{name:Rheumatology,displayTitle:Rheumatology,type:internal,url:},component:{type:content,l10title:,title:HUMIRA Clinical Profile,name:Accordion,position:content},content:{  type:,title:,name:},interaction:{type:Link,name:Rheumatology,id:abbv-accordion-455443886-1},mva:{name:,tier:,  type:,category:}}}}>							i classabbv-icon-add i-a>/i>													/div>																			div classabbv-accordion-content styledisplay: none;>																	            div classlink-list parbase>                                div classabbv-link-list  data-highlight-currentfalse>                  ul>                           li>                                                                                    				a data-digitaldata{digitalData:{page:{link:{name:Rheumatoid Arthritis,displayTitle:Rheumatoid Arthritis,type:internal,url:/content/humirapro/en-us/rheumatoid-arthritis},component:{type:navigation,l10title:,title:Rheumatology,name:link list,position:header},content:{},interaction:{type:link,name:Rheumatoid Arthritis,id:inner-abbv-linklist-1427406980-00},mva:{name:,tier:primary,type:,category:},menu:{}}}} class       content_moderate-to-severe  href/rheumatoid-arthritis target_self data-linktypeinternal>Rheumatoid Arthritis/a>	                                                      /li>                           li>                                                                                    				a data-digitaldata{digitalData:{page:{link:{name:Psoriatic Arthritis,displayTitle:Psoriatic Arthritis,type:internal,url:/content/humirapro/en-us/psoriatic-arthritis},component:{type:navigation,l10title:,title:Rheumatology,name:link list,position:header},content:{},interaction:{type:link,name:Psoriatic Arthritis,id:inner-abbv-linklist-1427406980-01},mva:{name:,tier:primary,type:,category:},menu:{}}}} class       content_active  href/psoriatic-arthritis target_self data-linktypeinternal>Psoriatic Arthritis/a>	                                                      /li>                           li>                                                                                    				a data-digitaldata{digitalData:{page:{link:{name:Ankylosing Spondylitis,displayTitle:Ankylosing Spondylitis,type:internal,url:/content/humirapro/en-us/ankylosing-spondylitis},component:{type:navigation,l10title:,title:Rheumatology,name:link list,position:header},content:{},interaction:{type:link,name:Ankylosing Spondylitis,id:inner-abbv-linklist-1427406980-02},mva:{name:,tier:primary,type:,category:},menu:{}}}} class       content_active  href/ankylosing-spondylitis target_self data-linktypeinternal>Ankylosing Spondylitis/a>	                                                      /li>                           li>                                                                                    				a data-digitaldata{digitalData:{page:{link:{name:Juvenile Idiopathic Arthritis,displayTitle:Juvenile Idiopathic Arthritis,type:internal,url:/content/humirapro/en-us/jia},component:{type:navigation,l10title:,title:Rheumatology,name:link list,position:header},content:{},interaction:{type:link,name:Juvenile Idiopathic Arthritis,id:inner-abbv-linklist-1427406980-03},mva:{name:,tier:primary,type:,category:},menu:{}}}} class       content_moderate-to-severe  href/jia target_self data-linktypeinternal>Juvenile Idiopathic Arthritis/a>	                                                      /li>                           li>                                                                                    				a data-digitaldata{digitalData:{page:{link:{name:Uveitis (Adult),displayTitle:Uveitis (Adult),type:internal,url:/content/humirapro/en-us/uveitis},component:{type:navigation,l10title:,title:Rheumatology,name:link list,position:header},content:{},interaction:{type:link,name:Uveitis (Adult),id:inner-abbv-linklist-1427406980-04},mva:{name:,tier:primary,type:,category:},menu:{}}}} class       content_non-infectious  href/uveitis target_self data-linktypeinternal>Uveitis (Adult)/a>	                                                      /li>                           li>                                                                                    				a data-digitaldata{digitalData:{page:{link:{name:Pediatric Uveitis,displayTitle:Pediatric Uveitis,type:internal,url:/content/humirapro/en-us/uveitis-pediatric},component:{type:navigation,l10title:,title:Rheumatology,name:link list,position:header},content:{},interaction:{type:link,name:Pediatric Uveitis,id:inner-abbv-linklist-1427406980-05},mva:{name:,tier:primary,type:,category:},menu:{}}}} class       content_non-infectious  href/uveitis-pediatric target_self data-linktypeinternal>Pediatric Uveitis/a>	                                                      /li>                     /ul>      /div>       /div>															/div>																		/div>				            														div data-trigger-forabbv-accordion-blade-2 classabbv-accordion-blade abbv-accordion-blade-2 >						div classabbv-accordion-blade-content tabindex0 rolebutton aria-labelDermatology aria-expandedfalse data-digitaldata{digitalData:{page:{link:{name:Dermatology,displayTitle:Dermatology,type:internal,url:},component:{type:content,l10title:,title:HUMIRA Clinical Profile,name:Accordion,position:content},content:{  type:,title:,name:},interaction:{type:Link,name:Dermatology,id:abbv-accordion-455443886-2},mva:{name:,tier:,  type:,category:}}}}>														div classabbv-accordion-blade-text    aria-hiddentrue>Dermatology/div>						/div>						div classabbv-accordion-blade-icon aria-hiddentrue data-digitaldata{digitalData:{page:{link:{name:Dermatology,displayTitle:Dermatology,type:internal,url:},component:{type:content,l10title:,title:HUMIRA Clinical Profile,name:Accordion,position:content},content:{  type:,title:,name:},interaction:{type:Link,name:Dermatology,id:abbv-accordion-455443886-2},mva:{name:,tier:,  type:,category:}}}}>							i classabbv-icon-add i-a>/i>													/div>																			div classabbv-accordion-content styledisplay: none;>																	            div classlink-list parbase>                                div classabbv-link-list  data-highlight-currentfalse>                  ul>                           li>                                                                                    				a data-digitaldata{digitalData:{page:{link:{name:Chronic Plaque Psoriasis,displayTitle:Chronic Plaque Psoriasis,type:internal,url:/content/humirapro/en-us/plaque-psoriasis},component:{type:navigation,l10title:,title:Dermatology,name:link list,position:header},content:{},interaction:{type:link,name:Chronic Plaque Psoriasis,id:inner-abbv-linklist-474682155-00},mva:{name:,tier:primary,type:,category:},menu:{}}}} class       content_moderate-to-severe  href/plaque-psoriasis target_self data-linktypeinternal>Chronic Plaque Psoriasis/a>	                                                      /li>                           li>                                                                                    				a data-digitaldata{digitalData:{page:{link:{name:Psoriatic Arthritis,displayTitle:Psoriatic Arthritis,type:internal,url:/content/humirapro/en-us/psoriatic-arthritis},component:{type:navigation,l10title:,title:Dermatology,name:link list,position:header},content:{},interaction:{type:link,name:Psoriatic Arthritis,id:inner-abbv-linklist-474682155-01},mva:{name:,tier:primary,type:,category:},menu:{}}}} class       content_active  href/psoriatic-arthritis target_self data-linktypeinternal>Psoriatic Arthritis/a>	                                                      /li>                           li>                                                                                    				a data-digitaldata{digitalData:{page:{link:{name:Hidradenitis Suppurativa,displayTitle:Hidradenitis Suppurativa ,type:internal,url:/hidradenitis-suppurativa},component:{type:navigation,l10title:,title:Dermatology,name:link list,position:header},content:{},interaction:{type:link,name:Hidradenitis Suppurativa ,id:inner-abbv-linklist-474682155-02},mva:{name:,tier:primary,type:,category:},menu:{}}}} class       content_moderate-to-severe  href/hidradenitis-suppurativa target_self data-linktypeinternal>Hidradenitis Suppurativa /a>	                                                      /li>                     /ul>      /div>       /div>															/div>																		/div>				            														div data-trigger-forabbv-accordion-blade-3 classabbv-accordion-blade abbv-accordion-blade-3 >						div classabbv-accordion-blade-content tabindex0 rolebutton aria-labelGastroenterology aria-expandedfalse data-digitaldata{digitalData:{page:{link:{name:Gastroenterology,displayTitle:Gastroenterology,type:internal,url:},component:{type:content,l10title:,title:HUMIRA Clinical Profile,name:Accordion,position:content},content:{  type:,title:,name:},interaction:{type:Link,name:Gastroenterology,id:abbv-accordion-455443886-3},mva:{name:,tier:,  type:,category:}}}}>														div classabbv-accordion-blade-text    aria-hiddentrue>Gastroenterology/div>						/div>						div classabbv-accordion-blade-icon aria-hiddentrue data-digitaldata{digitalData:{page:{link:{name:Gastroenterology,displayTitle:Gastroenterology,type:internal,url:},component:{type:content,l10title:,title:HUMIRA Clinical Profile,name:Accordion,position:content},content:{  type:,title:,name:},interaction:{type:Link,name:Gastroenterology,id:abbv-accordion-455443886-3},mva:{name:,tier:,  type:,category:}}}}>							i classabbv-icon-add i-a>/i>													/div>																			div classabbv-accordion-content styledisplay: none;>																	            div classlink-list parbase>                                div classabbv-link-list  data-highlight-currentfalse>                  ul>                           li>                                                                                    				a data-digitaldata{digitalData:{page:{link:{name:Crohn\u0027s Disease (Adult),displayTitle:Crohn’s Disease (Adult),type:internal,url:/content/humirapro/en-us/crohns-disease},component:{type:navigation,l10title:,title:Gastroenterology,name:link list,position:header},content:{},interaction:{type:link,name:Crohn’s Disease (Adult),id:inner-abbv-linklist-985216332-00},mva:{name:,tier:primary,type:,category:},menu:{}}}} class       content_moderate-to-severe  href/crohns-disease target_self data-linktypeinternal>Crohn’s Disease (Adult)/a>	                                                      /li>                           li>                                                                                    				a data-digitaldata{digitalData:{page:{link:{name:Pediatric Crohn\u0027s Disease,displayTitle:Pediatric Crohn’s Disease,type:internal,url:/content/humirapro/en-us/pediatric-crohns-disease},component:{type:navigation,l10title:,title:Gastroenterology,name:link list,position:header},content:{},interaction:{type:link,name:Pediatric Crohn’s Disease,id:inner-abbv-linklist-985216332-01},mva:{name:,tier:primary,type:,category:},menu:{}}}} class       content_moderate-to-severe  href/pediatric-crohns-disease target_self data-linktypeinternal>Pediatric Crohn’s Disease/a>	                                                      /li>                           li>                                                                                    				a data-digitaldata{digitalData:{page:{link:{name:Ulcerative Colitis (Adult),displayTitle:Ulcerative Colitis (Adult),type:internal,url:/content/humirapro/en-us/ulcerative-colitis},component:{type:navigation,l10title:,title:Gastroenterology,name:link list,position:header},content:{},interaction:{type:link,name:Ulcerative Colitis (Adult),id:inner-abbv-linklist-985216332-02},mva:{name:,tier:primary,type:,category:},menu:{}}}} class       content_moderate-to-severe  href/ulcerative-colitis target_self data-linktypeinternal>Ulcerative Colitis (Adult)/a>	                                                      /li>                           li>                                                                                    				a data-digitaldata{digitalData:{page:{link:{name:Pediatric Ulcerative Colitis,displayTitle:Pediatric Ulcerative Colitis,type:internal,url:/content/humirapro/en-us/pediatric-ulcerative-colitis},component:{type:navigation,l10title:,title:Gastroenterology,name:link list,position:header},content:{},interaction:{type:link,name:Pediatric Ulcerative Colitis,id:inner-abbv-linklist-985216332-03},mva:{name:,tier:primary,type:,category:},menu:{}}}} class       content_moderate-to-severe  href/pediatric-ulcerative-colitis target_self data-linktypeinternal>Pediatric Ulcerative Colitis/a>	                                                      /li>                     /ul>      /div>       /div>															/div>																		/div>				            														div data-trigger-forabbv-accordion-blade-4 classabbv-accordion-blade abbv-accordion-blade-4 >						div classabbv-accordion-blade-content tabindex0 rolebutton aria-labelOphthalmology aria-expandedfalse data-digitaldata{digitalData:{page:{link:{name:Ophthalmology,displayTitle:Ophthalmology,type:internal,url:},component:{type:content,l10title:,title:HUMIRA Clinical Profile,name:Accordion,position:content},content:{  type:,title:,name:},interaction:{type:Link,name:Ophthalmology,id:abbv-accordion-455443886-4},mva:{name:,tier:,  type:,category:}}}}>														div classabbv-accordion-blade-text    aria-hiddentrue>Ophthalmology/div>						/div>						div classabbv-accordion-blade-icon aria-hiddentrue data-digitaldata{digitalData:{page:{link:{name:Ophthalmology,displayTitle:Ophthalmology,type:internal,url:},component:{type:content,l10title:,title:HUMIRA Clinical Profile,name:Accordion,position:content},content:{  type:,title:,name:},interaction:{type:Link,name:Ophthalmology,id:abbv-accordion-455443886-4},mva:{name:,tier:,  type:,category:}}}}>							i classabbv-icon-add i-a>/i>													/div>																			div classabbv-accordion-content styledisplay: none;>																	            div classlink-list parbase>                                div classabbv-link-list  data-highlight-currentfalse>                  ul>                           li>                                                                                    				a data-digitaldata{digitalData:{page:{link:{name:Uveitis (Adult),displayTitle:Uveitis (Adult),type:internal,url:/content/humirapro/en-us/uveitis},component:{type:navigation,l10title:,title:Ophthalmology,name:link list,position:header},content:{},interaction:{type:link,name:Uveitis (Adult),id:inner-abbv-linklist-1874396097-00},mva:{name:,tier:primary,type:,category:},menu:{}}}} class       content_non-infectious  href/uveitis target_self data-linktypeinternal>Uveitis (Adult)/a>	                                                      /li>                           li>                                                                                    				a data-digitaldata{digitalData:{page:{link:{name:Pediatric Uveitis,displayTitle:Pediatric Uveitis,type:internal,url:/content/humirapro/en-us/uveitis-pediatric.html},component:{type:navigation,l10title:,title:Ophthalmology,name:link list,position:header},content:{},interaction:{type:link,name:Pediatric Uveitis,id:inner-abbv-linklist-1874396097-01},mva:{name:,tier:primary,type:,category:},menu:{}}}} class       content_non-infectious  href/uveitis-pediatric target_self data-linktypeinternal>Pediatric Uveitis/a>	                                                      /li>                     /ul>      /div>       /div>															/div>																		/div>				            			        /div>    /div>script typetext/javaScript>	if(abbvPageLoaded  false){		if(typeof accordion ! undefined){			addWindowLoad(accordion.init);		}	} else {		accordion.init();	}/script>/div>    /div>        /div>/div>                					/div>	/div>    /div>        /div>/div>            div classabbv-clear>/div>                    /div>    /div>		/div>	    	    	    	    	    	    	/div>            div classcontainer parbase>    div classabbv-container container-body section-break>                    div classflexbox parbase>			        		div classabbv-flex-container        align-items-center  >							                					div classabbv-flex-item         >                    div classimage-text parbase>!-- Begin: AbbVie Image + Text Component -->div classabbv-image-text image-right>                            div classabbv-image-content-container  i-b>                                    picture>        source media(min-width: 985px) srcset/content/dam/humirapro/images/icons/icon-lady.svg classabbv-image-text-img imageText001-large/>        source media(min-width: 601px) and (max-width: 984px) srcset/content/dam/humirapro/images/icons/icon-lady.svg classabbv-image-text-img imageText001-medium/>        source media(max-width: 600px) srcset/content/dam/humirapro/images/icons/icon-lady.svg classabbv-image-text-img imageText001-small/>        img src/content/dam/humirapro/images/icons/icon-lady.svg alt/>    /picture>        /div>        /div>!-- End: AbbVie Image + Text Component -->/div>/div>                							                					div classabbv-flex-item  flex-grow-2      >                    div classrich-text>        div classabbv-rich-text  abbv-rich-text-common>        h3>Request a Field Access Specialist/h3>p>Contact a Field Access Specialist to request patient-specific support with access and reimbursement./p>    /div>/div>            div classcta parbase>                                                                        	a data-digitaldata{digitalData:{page:{link:{name:Request Now,displayTitle:Request Now,type:internal,url:/content/humirapro/en-us/request-a-specialist},component:{type:content,l10title:,title:Request a Field Access Specialist,name:CTA,position:content},content:{},interaction:{type:,name:Request Now,id:abbv-cta-10966404},mva:{name:Resource Request A Specialist,tier:secondary,type:Link,category:Register for Service},menu:{}}}} class    abbv-button-primary    rolelink aria-labelRequest Now href/request-a-specialist target_self data-linktypeinternal aria-hiddenfalse>Request Now/a>                                                    /div>/div>                					/div>	/div>    /div>        /div>/section>							            div classabbv-inline-use-isi>            a idabbv_use_statement aria-hiddentrue>/a>            div classabbv-inline-use abbv-indication-swap>                            /div>            a idabbv_safety_information aria-hiddentrue>/a>            div classabbv-inline-safety abbv-indication-swap>                                                div classrich-text>    a idsafety-information aria-hiddentrue>/a>    div classabbv-rich-text humira-safety-bar-maximized-content H-pro-ISI abbv-rich-text-common>        h3 classhum-hcp-isi-title>IMPORTANT SAFETY INFORMATION for HUMIRA (adalimumab)sup>1/sup>/h3>p classhum-hcp-isi-plum-title-bold>b>SERIOUS INFECTIONS/b>/p>p classhum-hcp-isi-bold-text>Patients treated with HUMIRA are at increased risk for developing serious infections that may lead to hospitalization or death. Most patients who developed these infections were taking concomitant immunosuppressants such as methotrexate or corticosteroids./p>p classhum-hcp-isi-bold-text>Discontinue HUMIRA if a patient develops a serious infection or sepsis./p>p classhum-hcp-isi-bold-text>Reported infections include:/p>ul>li classhum-hcp-isi-bold-text>Active tuberculosis (TB), including reactivation of latent TB. Patients with TB have frequently presented with disseminated or extrapulmonary disease. Test patients for latent TB before HUMIRA use and during therapy. Initiate treatment for latent TB prior to HUMIRA use./li>li classhum-hcp-isi-bold-text>Invasive fungal infections, including histoplasmosis, coccidioidomycosis, candidiasis, aspergillosis, blastomycosis, and pneumocystosis. Patients with histoplasmosis or other invasive fungal infections may present with disseminated, rather than localized, disease. Antigen and antibody testing for histoplasmosis may be negative in some patients with active infection. Consider empiric anti-fungal therapy in patients at risk for invasive fungal infections who develop severe systemic illness./li>li classhum-hcp-isi-bold-text>Bacterial, viral, and other infections due to opportunistic pathogens, including Legionella and Listeria./li>/ul>p classhum-hcp-isi-bold-text>Carefully consider the risks and benefits of treatment with HUMIRA prior to initiating therapy in patients: 1. with chronic or recurrent infection, 2. who have been exposed to TB, 3. with a history of opportunistic infection, 4. who resided in or traveled in regions where mycoses are endemic, 5. with underlying conditions that may predispose them to infection. Monitor patients closely for the development of signs and symptoms of infection during and after treatment with HUMIRA, including the possible development of TB in patients who tested negative for latent TB infection prior to initiating therapy./p>ul>li>Do not start HUMIRA during an active infection, including localized infections./li>li>Patients older than 65 years, patients with co-morbid conditions, and/or patients taking concomitant immunosuppressants may be at greater risk of infection./li>li>If an infection develops, monitor carefully and initiate appropriate therapy./li>li>Drug interactions with biologic products: A higher rate of serious infections has been observed in RA patients treated with rituximab who received subsequent treatment with a TNF blocker. An increased risk of serious infections has been seen with the combination of TNF blockers with anakinra or abatacept, with no demonstrated added benefit in patients with RA. Concomitant administration of HUMIRA with other biologic DMARDs (e.g., anakinra or abatacept) or other TNF blockers is not recommended based on the possible increased risk for infections and other potential pharmacological interactions./li>/ul>p classhum-hcp-isi-plum-title-bold>b>MALIGNANCY/b>/p>p classhum-hcp-isi-bold-text>Lymphoma and other malignancies, some fatal, have been reported in children and adolescent patients treated with TNF blockers, including HUMIRA. Postmarketing cases of hepatosplenic T-cell lymphoma (HSTCL), a rare type of T-cell lymphoma, have been reported in patients treated with TNF blockers, including HUMIRA. These cases have had a very aggressive disease course and have been fatal. The majority of reported TNF blocker cases have occurred in patients with Crohn’s disease or ulcerative colitis and the majority were in adolescent and young adult males. Almost all of these patients had received treatment with azathioprine or 6-mercaptopurine concomitantly with a TNF blocker at or prior to diagnosis. It is uncertain whether the occurrence of HSTCL is related to use of a TNF blocker or a TNF blocker in combination with these other immunosuppressants./p>ul>li>Consider the risks and benefits of HUMIRA treatment prior to initiating or continuing therapy in a patient with known malignancy./li>li>In clinical trials, more cases of malignancies were observed among HUMIRA-treated patients compared to control patients./li>li>Non-melanoma skin cancer (NMSC) was reported during clinical trials for HUMIRA-treated patients. Examine all patients, particularly those with a history of prolonged immunosuppressant or PUVA therapy, for the presence of NMSC prior to and during treatment with HUMIRA./li>li>In HUMIRA clinical trials, there was an approximate 3-fold higher rate of lymphoma than expected in the general U.S. population. Patients with chronic inflammatory diseases, particularly those with highly active disease and/or chronic exposure to immunosuppressant therapies, may be at higher risk of lymphoma than the general population, even in the absence of TNF blockers./li>li>Postmarketing cases of acute and chronic leukemia were reported with TNF blocker use. Approximately half of the postmarketing cases of malignancies in children, adolescents, and young adults receiving TNF blockers were lymphomas; other cases included rare malignancies associated with immunosuppression and malignancies not usually observed in children and adolescents./li>/ul>p classhum-hcp-isi-plum-title-bold>b>HYPERSENSITIVITY/b>/p>ul>li>Anaphylaxis and angioneurotic edema have been reported following HUMIRA administration. If a serious allergic reaction occurs, stop HUMIRA and institute appropriate therapy./li>/ul>p classhum-hcp-isi-plum-title-bold>b>HEPATITIS B VIRUS REACTIVATION/b>/p>ul>li>Use of TNF blockers, including HUMIRA, may increase the risk of reactivation of hepatitis B virus (HBV) in patients who are chronic carriers. Some cases have been fatal./li>li>Evaluate patients at risk for HBV infection for prior evidence of HBV infection before initiating TNF blocker therapy./li>li>Exercise caution in patients who are carriers of HBV and monitor them during and after HUMIRA treatment./li>li>Discontinue HUMIRA and begin antiviral therapy in patients who develop HBV reactivation. Exercise caution when resuming HUMIRA after HBV treatment./li>/ul>p classhum-hcp-isi-plum-title-bold>b>NEUROLOGIC REACTIONS/b>/p>ul>li>TNF blockers, including HUMIRA, have been associated with rare cases of new onset or exacerbation of central nervous system and peripheral demyelinating diseases, including multiple sclerosis, optic neuritis, and Guillain-Barré syndrome./li>li>Exercise caution when considering HUMIRA for patients with these disorders; discontinuation of HUMIRA should be considered if any of these disorders develop./li>li>There is a known association between intermediate uveitis and central demyelinating disorders./li>/ul>p classhum-hcp-isi-plum-title-bold>b>HEMATOLOGIC REACTIONS/b>/p>ul>li>Rare reports of pancytopenia, including aplastic anemia, have been reported with TNF blockers. Medically significant cytopenia has been infrequently reported with HUMIRA./li>li>Consider stopping HUMIRA if significant hematologic abnormalities occur./li>/ul>p classhum-hcp-isi-plum-title-bold>b>CONGESTIVE HEART FAILURE/b>/p>ul>li>Worsening and new onset congestive heart failure (CHF) has been reported with TNF blockers. Cases of worsening CHF have been observed with HUMIRA; exercise caution and monitor carefully./li>/ul>p classhum-hcp-isi-plum-title-bold>b>AUTOIMMUNITY/b>/p>ul>li>Treatment with HUMIRA may result in the formation of autoantibodies and, rarely, in development of a lupus-like syndrome. Discontinue treatment if symptoms of a lupus-like syndrome develop./li>/ul>p classhum-hcp-isi-plum-title-bold>b>IMMUNIZATIONS/b>/p>ul>li>Patients on HUMIRA should not receive live vaccines./li>li>Pediatric patients, if possible, should be brought up to date with all immunizations before initiating HUMIRA therapy./li>li>Adalimumab is actively transferred across the placenta during the third trimester of pregnancy and may affect immune response in the em>in utero/em> exposed infant. The safety of administering live or live-attenuated vaccines in infants exposed to HUMIRA em>in utero/em> is unknown. Risks and benefits should be considered prior to vaccinating (live or live-attenuated) exposed infants./li>/ul>p classhum-hcp-isi-plum-title-bold>b>ADVERSE REACTIONS/b>/p>ul>li>The most common adverse reactions in HUMIRA clinical trials (>10%) were: infections (e.g., upper respiratory, sinusitis), injection site reactions, headache, and rash./li>/ul>p idindications> /p>h3>INDICATIONSsup>1/sup>/h3>ul>li>span classhum-hcp-isi-bold-text>Rheumatoid Arthritis:/span> HUMIRA is indicated, alone or in combination with methotrexate or other non-biologic DMARDs, for reducing signs and symptoms, inducing major clinical response, inhibiting the progression of structural damage, and improving physical function in adult patients with moderately to severely active rheumatoid arthritis./li>li>span classhum-hcp-isi-bold-text>Juvenile Idiopathic Arthritis:/span> HUMIRA is indicated, alone or in combination with methotrexate, for reducing signs and symptoms of moderately to severely active polyarticular juvenile idiopathic arthritis in patients 2 years of age and older./li>li>span classhum-hcp-isi-bold-text>Psoriatic Arthritis:/span> HUMIRA is indicated, alone or in combination with non-biologic DMARDs, for reducing signs and symptoms, inhibiting the progression of structural damage, and improving physical function in adult patients with active psoriatic arthritis./li>li>span classhum-hcp-isi-bold-text>Ankylosing Spondylitis:/span> HUMIRA is indicated for reducing signs and symptoms in adult patients with active ankylosing spondylitis./li>li>span classhum-hcp-isi-bold-text>Crohn’s Disease:/span> HUMIRA is indicated for the treatment of moderately to severely active Crohn’s disease in adults and pediatric patients 6 years of age and older./li>li>span classhum-hcp-isi-bold-text>Ulcerative Colitis:/span> HUMIRA is indicated for the treatment of moderately to severely active ulcerative colitis in adults and pediatric patients 5 years of age and older.br />u>Limitations of Use/u>:br />The effectiveness of HUMIRA has not been established in patients who have lost response to or were intolerant to TNF blockers./li>li>span classhum-hcp-isi-bold-text>Plaque Psoriasis:/span> HUMIRA is indicated for the treatment of adult patients with moderate to severe chronic plaque psoriasis who are candidates for systemic therapy or phototherapy, and when other systemic therapies are medically less appropriate. HUMIRA should only be administered to patients who will be closely monitored and have regular follow-up visits with a physician./li>li>span classhum-hcp-isi-bold-text>Hidradenitis Suppurativa:/span> HUMIRA is indicated for the treatment of moderate to severe hidradenitis suppurativa in patients 12 years of age and older./li>li>span classhum-hcp-isi-bold-text>Uveitis:/span> HUMIRA is indicated for the treatment of non-infectious intermediate, posterior, and panuveitis in adults and pediatric patients 2 years of age and older./li>/ul>p>b>Please see a hrefhttps://rxabbvie.com/pdf/humira.pdf target_blank data-digitaldata{"digitalData":{"page":{"link":{"name":"Full Prescribing Information","displayTitle":"Full Prescribing Information","type":"external","url":""},"component":{"type":"content","l10title":"","title":"isi","name":"RTE","position":"content"},"interaction":{"id":"rte-1657641853484","name":"Full Prescribing Information","type":"content"},"mva":{"name":"","tier":"secondary","type":"Download","category":"Prescribing Information"}}}}>Full Prescribing Information/a>./b>/p>p>US-HUM-210183br />/p>    /div>/div>                            /div>            a idabbv_miscisi aria-hiddentrue>/a>            div classabbv-inline-miscisi>                                                div classrich-text>        /div>                            /div>        /div>                                        div classrich-text>        div classabbv-rich-text container-body rte_references abbv-rich-text-common>        p>b>Reference:/b>/p>ol>li>HUMIRA Injection package insert. 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Most patients who developed these infections were taking concomitant immunosuppressants such as methotrexate or corticosteroids./p>						/div>											/div>				/div>			/div>			div classabbv-safety-bar-content abbv-safety-bar-less abbv-safety-bar-content-minimized-mobile>				div classabbv-row-container>					div classabbv-row abbv-row-flush>						div classabbv-col abbv-col-12>							h3 classhum-hcp-isi-title>IMPORTANT SAFETY INFORMATION & INDICATIONS for HUMIRA (adalimumab)sup>1/sup>/h3>p classhum-hcp-isi-plum-title-bold>b>SERIOUS INFECTIONS/b>/p>p classhum-hcp-isi-bold-text>Patients treated with HUMIRA are at increased risk for developing serious infections that may lead to hospitalization or death. Most patients who developed these infections were taking concomitant immunosuppressants such as methotrexate or corticosteroids./p>						/div>											/div>				/div>			/div>			div classabbv-safety-bar-content abbv-safety-bar-more abbv-safety-bar-content-minimized-desktop-more>				div classabbv-row-container>					div classabbv-row abbv-row-flush>						div classabbv-col abbv-col-12>							h3 classhum-hcp-isi-title>IMPORTANT SAFETY INFORMATION & INDICATIONS for HUMIRA (adalimumab)sup>1/sup>/h3>p classhum-hcp-isi-plum-title-bold>b>SERIOUS INFECTIONS/b>/p>p classhum-hcp-isi-bold-text>Patients treated with HUMIRA are at increased risk for developing serious infections that may lead to hospitalization or death. Most patients who developed these infections were taking concomitant immunosuppressants such as methotrexate or corticosteroids./p>						/div>											/div>				/div>			/div>			div classabbv-safety-bar-content abbv-safety-bar-more abbv-safety-bar-content-minimized-mobile-more>				div classabbv-row-container>					div classabbv-row abbv-row-flush>						div classabbv-col abbv-col-12>							h3 classhum-hcp-isi-title>IMPORTANT SAFETY INFORMATION & INDICATIONS for HUMIRA (adalimumab)sup>1/sup>/h3>p classhum-hcp-isi-plum-title-bold>b>SERIOUS INFECTIONS/b>/p>p classhum-hcp-isi-bold-text>Patients treated with HUMIRA are at increased risk for developing serious infections that may lead to hospitalization or death. Most patients who developed these infections were taking concomitant immunosuppressants such as methotrexate or corticosteroids./p>						/div>											/div>				/div>			/div>			div classabbv-safety-bar-content abbv-safety-bar-content-maximized>				div classabbv-row-container>					div classabbv-row abbv-row-flush>												div classabbv-col abbv-col-12>							            div classrich-text>    a idsafety-information aria-hiddentrue>/a>    div classabbv-rich-text humira-safety-bar-maximized-content H-pro-ISI abbv-rich-text-common>        h3 classhum-hcp-isi-title>IMPORTANT SAFETY INFORMATION for HUMIRA (adalimumab)sup>1/sup>/h3>p classhum-hcp-isi-plum-title-bold>b>SERIOUS INFECTIONS/b>/p>p classhum-hcp-isi-bold-text>Patients treated with HUMIRA are at increased risk for developing serious infections that may lead to hospitalization or death. Most patients who developed these infections were taking concomitant immunosuppressants such as methotrexate or corticosteroids./p>p classhum-hcp-isi-bold-text>Discontinue HUMIRA if a patient develops a serious infection or sepsis./p>p classhum-hcp-isi-bold-text>Reported infections include:/p>ul>li classhum-hcp-isi-bold-text>Active tuberculosis (TB), including reactivation of latent TB. Patients with TB have frequently presented with disseminated or extrapulmonary disease. Test patients for latent TB before HUMIRA use and during therapy. Initiate treatment for latent TB prior to HUMIRA use./li>li classhum-hcp-isi-bold-text>Invasive fungal infections, including histoplasmosis, coccidioidomycosis, candidiasis, aspergillosis, blastomycosis, and pneumocystosis. Patients with histoplasmosis or other invasive fungal infections may present with disseminated, rather than localized, disease. Antigen and antibody testing for histoplasmosis may be negative in some patients with active infection. Consider empiric anti-fungal therapy in patients at risk for invasive fungal infections who develop severe systemic illness./li>li classhum-hcp-isi-bold-text>Bacterial, viral, and other infections due to opportunistic pathogens, including Legionella and Listeria./li>/ul>p classhum-hcp-isi-bold-text>Carefully consider the risks and benefits of treatment with HUMIRA prior to initiating therapy in patients: 1. with chronic or recurrent infection, 2. who have been exposed to TB, 3. with a history of opportunistic infection, 4. who resided in or traveled in regions where mycoses are endemic, 5. with underlying conditions that may predispose them to infection. Monitor patients closely for the development of signs and symptoms of infection during and after treatment with HUMIRA, including the possible development of TB in patients who tested negative for latent TB infection prior to initiating therapy./p>ul>li>Do not start HUMIRA during an active infection, including localized infections./li>li>Patients older than 65 years, patients with co-morbid conditions, and/or patients taking concomitant immunosuppressants may be at greater risk of infection./li>li>If an infection develops, monitor carefully and initiate appropriate therapy./li>li>Drug interactions with biologic products: A higher rate of serious infections has been observed in RA patients treated with rituximab who received subsequent treatment with a TNF blocker. An increased risk of serious infections has been seen with the combination of TNF blockers with anakinra or abatacept, with no demonstrated added benefit in patients with RA. Concomitant administration of HUMIRA with other biologic DMARDs (e.g., anakinra or abatacept) or other TNF blockers is not recommended based on the possible increased risk for infections and other potential pharmacological interactions./li>/ul>p classhum-hcp-isi-plum-title-bold>b>MALIGNANCY/b>/p>p classhum-hcp-isi-bold-text>Lymphoma and other malignancies, some fatal, have been reported in children and adolescent patients treated with TNF blockers, including HUMIRA. Postmarketing cases of hepatosplenic T-cell lymphoma (HSTCL), a rare type of T-cell lymphoma, have been reported in patients treated with TNF blockers, including HUMIRA. These cases have had a very aggressive disease course and have been fatal. The majority of reported TNF blocker cases have occurred in patients with Crohn’s disease or ulcerative colitis and the majority were in adolescent and young adult males. Almost all of these patients had received treatment with azathioprine or 6-mercaptopurine concomitantly with a TNF blocker at or prior to diagnosis. It is uncertain whether the occurrence of HSTCL is related to use of a TNF blocker or a TNF blocker in combination with these other immunosuppressants./p>ul>li>Consider the risks and benefits of HUMIRA treatment prior to initiating or continuing therapy in a patient with known malignancy./li>li>In clinical trials, more cases of malignancies were observed among HUMIRA-treated patients compared to control patients./li>li>Non-melanoma skin cancer (NMSC) was reported during clinical trials for HUMIRA-treated patients. Examine all patients, particularly those with a history of prolonged immunosuppressant or PUVA therapy, for the presence of NMSC prior to and during treatment with HUMIRA./li>li>In HUMIRA clinical trials, there was an approximate 3-fold higher rate of lymphoma than expected in the general U.S. population. Patients with chronic inflammatory diseases, particularly those with highly active disease and/or chronic exposure to immunosuppressant therapies, may be at higher risk of lymphoma than the general population, even in the absence of TNF blockers./li>li>Postmarketing cases of acute and chronic leukemia were reported with TNF blocker use. Approximately half of the postmarketing cases of malignancies in children, adolescents, and young adults receiving TNF blockers were lymphomas; other cases included rare malignancies associated with immunosuppression and malignancies not usually observed in children and adolescents./li>/ul>p classhum-hcp-isi-plum-title-bold>b>HYPERSENSITIVITY/b>/p>ul>li>Anaphylaxis and angioneurotic edema have been reported following HUMIRA administration. If a serious allergic reaction occurs, stop HUMIRA and institute appropriate therapy./li>/ul>p classhum-hcp-isi-plum-title-bold>b>HEPATITIS B VIRUS REACTIVATION/b>/p>ul>li>Use of TNF blockers, including HUMIRA, may increase the risk of reactivation of hepatitis B virus (HBV) in patients who are chronic carriers. Some cases have been fatal./li>li>Evaluate patients at risk for HBV infection for prior evidence of HBV infection before initiating TNF blocker therapy./li>li>Exercise caution in patients who are carriers of HBV and monitor them during and after HUMIRA treatment./li>li>Discontinue HUMIRA and begin antiviral therapy in patients who develop HBV reactivation. Exercise caution when resuming HUMIRA after HBV treatment./li>/ul>p classhum-hcp-isi-plum-title-bold>b>NEUROLOGIC REACTIONS/b>/p>ul>li>TNF blockers, including HUMIRA, have been associated with rare cases of new onset or exacerbation of central nervous system and peripheral demyelinating diseases, including multiple sclerosis, optic neuritis, and Guillain-Barré syndrome./li>li>Exercise caution when considering HUMIRA for patients with these disorders; discontinuation of HUMIRA should be considered if any of these disorders develop./li>li>There is a known association between intermediate uveitis and central demyelinating disorders./li>/ul>p classhum-hcp-isi-plum-title-bold>b>HEMATOLOGIC REACTIONS/b>/p>ul>li>Rare reports of pancytopenia, including aplastic anemia, have been reported with TNF blockers. Medically significant cytopenia has been infrequently reported with HUMIRA./li>li>Consider stopping HUMIRA if significant hematologic abnormalities occur./li>/ul>p classhum-hcp-isi-plum-title-bold>b>CONGESTIVE HEART FAILURE/b>/p>ul>li>Worsening and new onset congestive heart failure (CHF) has been reported with TNF blockers. Cases of worsening CHF have been observed with HUMIRA; exercise caution and monitor carefully./li>/ul>p classhum-hcp-isi-plum-title-bold>b>AUTOIMMUNITY/b>/p>ul>li>Treatment with HUMIRA may result in the formation of autoantibodies and, rarely, in development of a lupus-like syndrome. Discontinue treatment if symptoms of a lupus-like syndrome develop./li>/ul>p classhum-hcp-isi-plum-title-bold>b>IMMUNIZATIONS/b>/p>ul>li>Patients on HUMIRA should not receive live vaccines./li>li>Pediatric patients, if possible, should be brought up to date with all immunizations before initiating HUMIRA therapy./li>li>Adalimumab is actively transferred across the placenta during the third trimester of pregnancy and may affect immune response in the em>in utero/em> exposed infant. The safety of administering live or live-attenuated vaccines in infants exposed to HUMIRA em>in utero/em> is unknown. Risks and benefits should be considered prior to vaccinating (live or live-attenuated) exposed infants./li>/ul>p classhum-hcp-isi-plum-title-bold>b>ADVERSE REACTIONS/b>/p>ul>li>The most common adverse reactions in HUMIRA clinical trials (>10%) were: infections (e.g., upper respiratory, sinusitis), injection site reactions, headache, and rash./li>/ul>p idindications> /p>h3>INDICATIONSsup>1/sup>/h3>ul>li>span classhum-hcp-isi-bold-text>Rheumatoid Arthritis:/span> HUMIRA is indicated, alone or in combination with methotrexate or other non-biologic DMARDs, for reducing signs and symptoms, inducing major clinical response, inhibiting the progression of structural damage, and improving physical function in adult patients with moderately to severely active rheumatoid arthritis./li>li>span classhum-hcp-isi-bold-text>Juvenile Idiopathic Arthritis:/span> HUMIRA is indicated, alone or in combination with methotrexate, for reducing signs and symptoms of moderately to severely active polyarticular juvenile idiopathic arthritis in patients 2 years of age and older./li>li>span classhum-hcp-isi-bold-text>Psoriatic Arthritis:/span> HUMIRA is indicated, alone or in combination with non-biologic DMARDs, for reducing signs and symptoms, inhibiting the progression of structural damage, and improving physical function in adult patients with active psoriatic arthritis./li>li>span classhum-hcp-isi-bold-text>Ankylosing Spondylitis:/span> HUMIRA is indicated for reducing signs and symptoms in adult patients with active ankylosing spondylitis./li>li>span classhum-hcp-isi-bold-text>Crohn’s Disease:/span> HUMIRA is indicated for the treatment of moderately to severely active Crohn’s disease in adults and pediatric patients 6 years of age and older./li>li>span classhum-hcp-isi-bold-text>Ulcerative Colitis:/span> HUMIRA is indicated for the treatment of moderately to severely active ulcerative colitis in adults and pediatric patients 5 years of age and older.br />u>Limitations of Use/u>:br />The effectiveness of HUMIRA has not been established in patients who have lost response to or were intolerant to TNF blockers./li>li>span classhum-hcp-isi-bold-text>Plaque Psoriasis:/span> HUMIRA is indicated for the treatment of adult patients with moderate to severe chronic plaque psoriasis who are candidates for systemic therapy or phototherapy, and when other systemic therapies are medically less appropriate. HUMIRA should only be administered to patients who will be closely monitored and have regular follow-up visits with a physician./li>li>span classhum-hcp-isi-bold-text>Hidradenitis Suppurativa:/span> HUMIRA is indicated for the treatment of moderate to severe hidradenitis suppurativa in patients 12 years of age and older./li>li>span classhum-hcp-isi-bold-text>Uveitis:/span> HUMIRA is indicated for the treatment of non-infectious intermediate, posterior, and panuveitis in adults and pediatric patients 2 years of age and older./li>/ul>p>b>Please see a hrefhttps://rxabbvie.com/pdf/humira.pdf target_blank data-digitaldata{"digitalData":{"page":{"link":{"name":"Full Prescribing Information","displayTitle":"Full Prescribing Information","type":"external","url":""},"component":{"type":"content","l10title":"","title":"isi","name":"RTE","position":"content"},"interaction":{"id":"rte-1657641853484","name":"Full Prescribing Information","type":"content"},"mva":{"name":"","tier":"secondary","type":"Download","category":"Prescribing Information"}}}}>Full Prescribing Information/a>./b>/p>p>US-HUM-210183br />/p>    /div>/div>						/div>								 			/div>				/div>			/div> 		/div>	!-- End: AbbVie Safety Bar Component -->	/div>                            div classnewpar new section>/div>                            div classpar iparys_inherited>                /div>    		svg classabbv-svg-defs version1.1 xmlnshttp://www.w3.org/2000/svg xmlns:xlinkhttp://www.w3.org/1999/xlink xml:spacepreserve>		defs>		  linearGradient idabbv-h-gradient-1 x10 y10 x21 y20>			stop offset0% stop-color#23417b/>			stop offset100% stop-color#071d49/>		  /linearGradient>		  linearGradient idabbv-h-gradient-2 x10 y10 x21 y20>			stop offset0% stop-color#c0bdc2/>			stop offset100% stop-color#96999e/>		  /linearGradient>		  linearGradient idabbv-v-gradient-1 x10 y10 x20 y21>			stop offset0% stop-color#23417b/>			stop offset100% stop-color#071d49/>		  /linearGradient>		  linearGradient idabbv-v-gradient-2 x10 y10 x20 y21>			stop offset0% stop-color#c0bdc2/>			stop offset100% stop-color#96999e/>		  /linearGradient>		  radialGradient idabbv-r-gradient-1>			stop offset0% stop-color#23417b/>			stop offset100% stop-color#071d49/>		  /radialGradient>		  radialGradient idabbv-r-gradient-2>			stop offset0% stop-color#c0bdc2/>			stop offset100% stop-color#96999e/>		  /radialGradient>		   clipPath idabbv-square-point clipPathUnitsobjectBoundingBox>			rect x.15 y.15 width.7 height.7/>		  /clipPath>		  clipPath idabbv-diamond-point clipPathUnitsobjectBoundingBox>			path dM0,.5 L.5,0 L1,.5 L.5,1 z/>		  /clipPath>		  linearGradient idgradient-red x1300 y1-260 x2300 y20 gradientUnitsuserSpaceOnUse>    stop stop-color#ae235f stop-opacity0 offset0 />    stop stop-color#ae235f stop-opacity0.15 offset1 />/linearGradient>linearGradient idgradient-red--chart x1300 y1-260 x2300 y20 gradientUnitsuserSpaceOnUse>    stop stop-color#ae235f stop-opacity0 offset0 />    stop stop-color#ae235f stop-opacity0.25 offset1 />/linearGradient>linearGradient idgradient-light-red--chart x1300 y1-260 x2300 y20 gradientUnitsuserSpaceOnUse>    stop stop-color#FC99CF stop-opacity0 offset0 />    stop stop-color#FC99CF stop-opacity0.25 offset1 />/linearGradient>linearGradient idgradient-blue--chart x1300 y1-260 x2300 y20 gradientUnitsuserSpaceOnUse>    stop stop-color#4178C7 stop-opacity0 offset0 />    stop stop-color#4178C7 stop-opacity0.25 offset1 />/linearGradient>		/defs>	/svg>	/div>										    script src/etc/clientlibs/common-elements/clientlibs/v1/components.min.50c3a4126f837f0141f17201106b436f.js>/script>						/body>            /html>

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Date	Domain	IP
www-p.humirapro.com	2024-08-01	3.163.24.46
www.humirapro.com	2024-11-18	204.246.191.128

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