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Domain > www.dashgenomics.com
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Date
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2020-04-26
54.193.18.17
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2025-12-07
172.67.130.218
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HTTP/1.1 200 OKDate: Sun, 07 Dec 2025 06:56:27 GMTContent-Type: text/html; charsetUTF-8Transfer-Encoding: chunkedConnection: keep-aliveServer: cloudflareNel: {report_to:cf-nel,success_fraction:0.0,max_age:604800}Vary: Accept-EncodingReport-To: {group:cf-nel,max_age:604800,endpoints:{url:https://a.nel.cloudflare.com/report/v4?sGIEC908drZ5OeeJfEERrkgnk9xP4TAlKht7KJW8RO5SNrAvs7sVEvBwVc1iWIix%2FG6rJeIcAM2IEzp9EJ8bD6H3g%2BdK1GT0mbKRXKsWyuMmNqKNX}}cf-cache-status: DYNAMICCF-RAY: 9aa21f86ddc8da91-PDXalt-svc: h3:443; ma86400 !DOCTYPE html>html langen> head>meta http-equivContent-Type contenttext/html; charsetUTF-8> script> dataLayer { pageCategory: signup, visitorType: high-value };/script> !-- Begin Inspectlet Asynchronous Code -->script typetext/javascript>(function() { window.__insp window.__insp || ; __insp.push(wid, 1158903497); var ldinsp function() { if (typeof window.__inspld ! undefined) return; window.__inspld 1; var insp document.createElement(script); insp.type text/javascript; insp.async true; insp.id inspsync; insp.src (https: document.location.protocol ? https : http) + ://cdn.inspectlet.com/inspectlet.js?wid1158903497&r + Math.floor(new Date().getTime() / 3600000); var x document.getElementsByTagName(script)0; x.parentNode.insertBefore(insp, x); }; setTimeout(ldinsp, 0);})();/script> !-- End Inspectlet Asynchronous Code --> title>Dash Genomics - Personalized Alzheimer’s disease risk/title> link relcanonical hrefhttps://www.dashgenomics.com/>meta nameRobots contentindex, follow> meta namedescription contentResearch based individual Alzheimers disease risk using 23andMe and Ancestry genomic data> meta namekeywords contentDNA,Alzheimers,Personal,Risk,Research,Disease,Genomic,Genetic,23andMe,Ancestry,Data> meta nameviewport contentwidthdevice-width, initial-scale1.0> meta http-equivX-UA-Compatible contentIEedge> meta nameauthor contentDash Genomics> !-- Bootstrap v4.0.0 CSS via CDN --> !-- link relstylesheet hrefhttps://maxcdn.bootstrapcdn.com/bootstrap/4.0.0/css/bootstrap.min.css> --> link relstylesheet hrefassets/css/bootstrap.min.css> !-- Plugins required on all pages NOTE: Additional non-required plugins are loaded ondemand as of AppStrap 2.5 --> !-- Theme style --> !-- link hrefassets/css/theme-style.min.css relstylesheet> --> link hrefassets/css/theme-style.css relstylesheet> !--Your custom colour override--> link hrefassets/css/colour-dash.css idcolour-scheme relstylesheet> !-- link href# idcolour-scheme relstylesheet> --> !-- Your custom override --> link hrefassets/css/custom-style.css relstylesheet> !-- Optional: ICON SETS --> !-- Iconset: Font Awesome 5.0.4 via CDN --> link hrefreleases/v5.0.13/css/all.css relstylesheet> !-- Iconset: ionicons - http://ionicons.com/ --> link hrefionicons/2.0.1/css/ionicons.min.css relstylesheet> !-- Iconset: Linearicons - https://linearicons.com/free --> link hreffree/1.0.0/icon-font.min.css relstylesheet> !-- Le fav and touch icons - @todo: fill 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--> a classnavbar-brand href/ titleHome> img srcassets/img/logo.png classimg-fluid logo> /a> !-- hamburger botton for mobile --> button classnavbar-toggler typebutton data-togglecollapse data-target#navbarResponsive> span classnavbar-toggler-icon>span> /span>/span>/button> div classcollapse navbar-collapse idnavbarResponsive> ul classnavbar-nav ml-auto dropdown-effect-fade text-uppercase font-weight-bold text-sm text-center styleline-height: 50px;> li classnav-item> a classnav-link href#faq data-togglescroll-link>Faq/a> /li> div classdropdown-divider>/div> li classnav-item> a classnav-link href#product data-togglescroll-link>Product/a> /li> div classdropdown-divider>/div> li classnav-item nav-item-login> a classnav-link href#login data-togglescroll-link>Log in/a> /li> div classdropdown-divider nav-item-login>/div> li classnav-item nav-item-login> a href#create-account classbtn btn-primary btn-lg btn-rounded text-uppercase font-weight-bold px-3 mt-md-2 my-0 button-signup>Sign Up/a> /li> div classdropdown-divider nav-item-login>/div> li classnav-item nav-item-loggedIn dropdown styledisplay:none> a classnav-link dropdown-toggle href# idaccountName data-toggledropdown data-hoverdropdown>/a> !-- Menu --> div classdropdown-menu> a href#report idref-return-report classdropdown-item>Report/a> a href#change-password idref-change-password classdropdown-item>Change password/a> a href# idref-logout classdropdown-item>Log out/a> /div> /li>li classnav-item nav-item-loggedIn dropdown styledisplay:none>a hrefhttps://www.ristorantelabotticella.com/>Migliori Casino Online 2025/a>/li>li classnav-item nav-item-loggedIn dropdown styledisplay:none>a hrefhttps://uk-sobs.org.uk/>Casino Not On Gamstop/a>/li>li classnav-item nav-item-loggedIn dropdown styledisplay:none>a hrefhttps://www.livingcoasts.org.uk/>Online Casinos UK/a>/li>li classnav-item nav-item-loggedIn dropdown styledisplay:none>a hrefhttps://www.powwownow.co.uk/>Non Gamstop Casinos UK/a>/li>li classnav-item nav-item-loggedIn dropdown styledisplay:none>a hrefhttps://gdalabel.org.uk/>Non Gamstop Casinos/a>/li> /ul> /div> /div> /nav> /div> !-- @Region: #content --> div idcontent classpt-6> div classupload page> div classcontainer content-spacer-top> nav classbreadcrumb> h4> span classbreadcrumb-item>i classfas fa-check icon-1.5x>/i>Order Completed/span> span classbreadcrumb-item active>Upload/span> /h4> /nav> div classcontainer mb-4 bg-light p-3 rounded mb-4 idupload> div classrow> div classcol-md-6 my-4> h4 classtext-uppercase font-weight-bold mb-2>Compatible data sources:/h4> span classfont-weight-normal mt-2>Follow the data sources instruction for data downloading./span> div> ul classmt-4> li> p> a name23andmeLink>23andMe/a> small> (See a name23andmeHowToLink>FAQ23andme/a>)/small> /p> /li> li> p> a nameancestryLink>Ancestry.com/a> small> (See a nameancestryHowToLink>FAQAncestry/a>)/small> /p> /li> /ul> /div> /div> div classcol-md-6 my-4> h4 classtext-uppercase font-weight-bold mb-2>Upload your genetic data/h4> span classfont-weight-normal mt-2 mb-5>Get your report in seconds/span> form idform-upload enctypemultipart/form-data> div classform-group mt-4> input namefile typefile classform-control-file aria-describedbyfileHelp> div classinvalid-feedback fileError> File must be under 30 mb. /div> /div> div classform-group> input idbutton-upload typebutton classbtn btn-primary valueUpload disabled> /div> /form> div classprogress progress-lg> div idprocess-progress classprogress-bar roleprogressbar aria-valuenow0 aria-valuemin0 aria-valuemax100>/div> /div> /div> /div> div idconfirmation-success classtext-center mb-4 d-none> hr classmb-4 w-50 mx-auto> div classform-group container> table classtable table-borderless> tbody> tr classw-100> td classw-25 text-right align-middle> i classfa fa-check-circle icon-4x text-success>/i> /td> td classw-75> h5> We have successfully processed your genotype profile. /h5> h5> Please click the button below to access your report. /h5> /td> /tr> /tbody> /table> /div> div> form idform-consent> div classrow> input typebutton classbutton-consent m-auto btn btn-lg btn-primary text-uppercase float-right font-weight-bold btn-rounded px-4 valueProceed to my report> /div> /form> /div> /div> div idconfirmation-error classtext-center mb-4 d-none> hr classmb-4 w-50 mx-auto> div classform-group container> table classtable table-borderless> tbody> tr> td classw-25 text-right align-middle> i classion ion-alert-circled icon-4x text-danger>/i> /td> td classw-75 text-center align-middle> h5> The file is not compatible with Polygenic Alzheimers Disease risk analysis. /h5> h5> Please upload another file br> or contact a href/cdn-cgi/l/email-protection#3541505458755154465d52505b5a585c56461b565a580a4640575f5056410864405046415c5a5b4610070554575a4041100705515441541007054045595a54511b>span class__cf_email__ data-cfemail522637333f123633213a35373c3d3f3b31217c313d3f>email protected/span>/a>. /h5> /td> /tr> /tbody> /table> /div> div> form> div classrow mb-3> input typebutton classbutton-reupload m-auto btn btn-lg btn-primary float-right text-uppercase font-weight-bold btn-rounded px-4 valueReupload another file> !-- a href#upload classbtn btn-primary button-reupload>I want to reupload another file/a> --> /div> div classrow> a href# classlink-not-proceed m-auto data-togglemodal data-target#confirm-cancel-order>I do NOT want to proceed/a> /div> /form> /div> /div> div idconfirmation-warning classtext-center mb-4 d-none> hr classmb-4 w-50 mx-auto> div classform-group container> table classtable table-borderless> tbody> tr> td classw-25 text-right align-middle> i classfa fa-info-circle icon-4x text-warning>/i> /td> td classw-75 align-middle> h5> small> span idprocessing-warning-content>/span> /small> /h5> /td> /tr> /tbody> /table> /div> div> form> div classrow mb-4> input typebutton classbutton-consent m-auto btn btn-lg btn-primary float-right text-uppercase font-weight-bold btn-rounded px-4 valueProceed to my report> /div> div classrow> a href# classlink-not-proceed m-auto data-togglemodal data-target#confirm-not-proceed>I do NOT want to proceed/a> /div> /form> /div> /div> /div> /div> /div> div classmodal fade idconfirm-not-proceed tabindex-1 roledialog aria-labelledbymyModalLabel aria-hiddentrue> /div> div classmodal fade idconfirm-cancel-order tabindex-1 roledialog aria-labelledbymyModalLabel aria-hiddentrue> /div> div idhighlighted classhome page> !-- Image Banner: Use the the data-bg-img functionality to create a simple image banner Use spacer classes to make the banner larger with padding, allows for easy responsive changes too see: elements-ctas.htm To make the banner full height add the attributes: data-togglefull-height data-offset#header --> div namebanner classbg-white overlay overlay-op-6 text-center px-3 py-5 py-lg-10 flex-valign bg-img blazy-bg b-loaded stylebackground-position-x: center; background-position-y: 30%; background-image: url(assets/img/homepage.jpg);> h2 classdisplay-4 text-white data-animate-delay0.2 styleanimation-delay: 0.2s;> span classfont-weight-bold>Personalized Alzheimer’s disease risk/span> br> from your genomic data /h2> !-- h3 classtext-grey font-weight-normal data-animate-delay0.35 styleanimation-delay: 0.35s;> Kickstart your next web project with AppStrap! /h3> --> hr classhr-primary hr-lg w-20 mx-auto my-4 data-animate-delay0.45 styleanimation-delay: 0.45s;> div namehome-pricing classcontainer text-white mt-3 mb-4 text-center> /div> div> a href#create-account classbutton-signup btn btn-primary btn-rounded btn-xl py-lg-3 px-lg-6 text-uppercase font-weight-bold>Get Started/a> /div> /div> div classcontainer> hr classhr-lg mt-7 mb-8 w-10 mx-auto hr-primary> h3 classtext-center text-uppercase font-weight-bold my-0> Your personal risk profile,br> grounded in research /h3> hr classmb-4 w-50 mx-auto> div classrow col-md-12> div classcol-md-6 mt-3> a href#product>img srcassets/img/macbook_wscreenshot.png classimg-fluid altmacbook>/a> p classtext-center font-weight-bold font-italic>Read more about the science featured in a classfold-weight-bold hrefhttps://www.wired.com/story/polygenic-alzheimers-test-predicts-age-of-disease-onset/ target_new>Wired/a>/p> /div> div classcol-md-6 mt-3 d-flex align-items-center> div classalign-middle> p classtext-justify mt-2>Dash Genomics has partnered with a namehealthLytixLink>HealthLytix/a> to bring you a new model to understand your individual risk of Alzheimer’s disease using a name23andmeLink>23andMe/a> and a nameancestryLink>Ancestry.com/a> data. Based on research from a nameucsdLink>UC San Diego/a> and a nameucsfLink>UC San Francisco/a>, this model estimates your personalized risk as a function of age and your genetic information. Online games can support Alzheimers patients by enhancing cognitive function, improving memory, and promoting mental agility through engaging challenges. In 2025, initiatives like a hrefhttps://kimi-siegel.de/wettanbieter-ohne-oasis/>Wetten ohne Oasis 2025/a> may focus on games designed to stimulate brain activity safely, providing entertainment while fostering social connections and maintaining cognitive health in a secure environment. /p> br> p classfont-weight-bold font-italic> Learn more about our a href#product>product/a> and see a href#demoreport>a sample of our report/a>. /p> /div> /div> /div> hr classhr-lg mt-7 mb-8 w-10 mx-auto hr-primary> div classcontainer namehowItWorks> /div> div data-animatefadeIn data-animate-duration0.8 styleanimation-duration: 0.8s; classanimated animated-done> hr classhr-lg mt-7 mb-8 w-10 mx-auto hr-primary> h3 classtext-center text-uppercase font-weight-bold my-0> Delve into the Research /h3> hr classmb-4 w-50 mx-auto> p classtext-justify> The proprietary algorithm used by Dash Genomics was developed by a namehealthLytixLink>HealthLytix/a>, a precision health company in San Diego, and is based on cutting-edge research from a nameucsdLink>UC San Diego/a> and a nameucsfLink>UC San Francisco/a>. The research looks at age-specific risk of developing Alzheimer’s disease based on genetic markers that have never been used before for estimating risk. /p> p classtext-justify> Individual genetic risk of Alzheimer’s disease is quantified based on your genetic markers and age. Several studies have found that engaging in brain-stimulating activities like trading cryptocurrencies on online platforms like a hrefhttps://kryptoszene.de/bitcoin-robot/bitcoin-gemini/>bitcoin gemini app/a> can lessen an individuals genetic risk of Alzheimers disease to some extent. The automatic trading software Bitcoin Gemini is easy-to-use and can be used by even novice traders. The model looks at the similarities between your genetic profile and the average risk in the group analyzed in the research. /p> p classfont-italic> Find more details about the research team’s analysis, including methodology and findings, in their a hrefhttp://journals.plos.org/plosmedicine/article?id10.1371/journal.pmed.1002258 target_new>published research papers/a>. /p> /div> div data-animatefadeIn data-animate-duration0.8 styleanimation-duration: 0.8s; classanimated animated-done> hr classhr-lg mt-7 mb-8 w-10 mx-auto hr-primary> h3 classtext-center text-uppercase font-weight-bold my-0> As Featured in /h3> hr classmb-4 w-50 mx-auto> /div> /div> div classcontainer> div classrow text-center bg-light> div classcol-md-2 my-3> a hrefhttps://www.wired.com/story/polygenic-alzheimers-test-predicts-age-of-disease-onset/ target_new>img srcassets/img/featured/logo-wired.svg classimg-fluid mt-2 stylemax-height: 60px altWired>/a> /div> div classcol-md-3 my-3> a hrefhttps://www.technologyreview.com/s/610251/forecasts-of-genetic-fate-just-got-a-lot-more-accurate/ target_new>img srcassets/img/featured/logo-mit-tech-review.svg classimg-fluid stylemax-height: 60px altMIT Technology Review>/a> /div> div classcol-md-2 my-3> a hrefhttps://onlinelibrary.wiley.com/doi/full/10.1002/ana.25029 target_new>img srcassets/img/featured/logo-neurology.jpg classimg-fluid stylemax-height: 60px altMIT Technology Review>/a> /div> div classcol-md-3 my-1> a hrefhttp://www.sandiegouniontribune.com/business/biotech/sd-me-alzheimers-test-20170922-story.html target_new>img srcassets/img/featured/logo_san-diego-union-tribune.png classimg-fluid mt-2 stylemax-height: 60px altUnion Tribune>/a> /div> div classcol-md-2 my-3> a hrefhttp://journals.plos.org/plosmedicine/article?id10.1371/journal.pmed.1002258 target_new>img srcassets/img/featured/logo-plos-medicine.png classimg-fluid mt-2 stylemax-height: 60px; min-height: 30px altPlos Medicine>/a> /div> /div> /div> /div> div classlogin page> div classcontainer login content-spacer-top> div classrow> div classcontainer col-md-9> div idalert-invalid-login classalert alert-danger rolealert styledisplay:none> There was an error with your login. /div> div idlogin> !-- Login form --> form idform-login classform-login form-wrapper form-narrow> h3> span>Login/span> hr classw-50 to-left mb-0> small classmt-4>Not signed up? a href#create-account classbutton-signup>Sign up here/a>/small> /h3>p classmargin-bottom-2rem>/p>p> /p>div classform-group> label classsr-only forloginEmail>Email/label> input typeemail nameloginEmail classform-control email placeholderEmail> /div> div classform-group> label classsr-only forloginPassword value>Password/label> input typepassword nameloginPassword classform-control password placeholderPassword value> /div> small>a href#forgot-password text-alignleft>Forgot Password?/a>/small> button idbutton-login typebutton classbtn btn-primary stylefloat: right;>Login/button> /form> /div> /div> /div> /div> /div> div classforgot-password page> div classcontainer forgot-password content-spacer-top> div classrow> div classcontainer col-md-10> div idalert-reset-account-not-found classalert alert-danger rolealert styledisplay:none> We can not find the email in our records, please use the email address that you used to register the account. Thanks. /div> a classfloat-left href#login text-alignleft>Back/a> div idforgot-password> form idform-forgot-password classform-forgot-password form-wrapper form-narrow styleoverflow: auto;> h3> span>Reset password/span> hr classw-50 to-left mb-0> small classmargin-bottom-2rem>Please provide your email/small> /h3>p classmargin-bottom-2rem>/p> div classform-group> label classsr-only foremail>Email/label> input typeemail nameresetEmail classform-control email placeholderEmail required> div classinvalid-feedback> Not a valid email address /div> /div> div classform-group> label classsr-only forforgotPasswordButton>Reset Password Button/label> button idbutton-forgot-password typebutton classbtn btn-primary float-right>Reset Password/button> /div> /form> /div> /div> /div> /div> /div> div classchange-password page> div classcontainer change-password content-spacer-top> div classrow> div classcontainer col-md-10> div idalert-password-invalid classalert alert-danger rolealert styledisplay:none> span idalert-password-invalid-msg>/span> /div> div idalert-password-ok classalert alert-success rolealert styledisplay:none> Your password was successfully updated. /div> a classfloat-left href#report text-alignleft>< Back/a> div idchange-password> !-- change password form --> form idform-change-password classform-change-password form-wrapper form-narrow styleoverflow: auto;> h3> span>Change password/span> hr classw-50 to-left mb-0> /h3>p classmargin-bottom-2rem>/p>p> /p>div classform-group> label classsr-only foroldPassword>Old Password/label> input typepassword nameoldPassword classform-control password placeholderOld Password> div classinvalid-feedback old-password> Required /div> /div> div classform-group> label classsr-only fornewPassword value>New Password/label> input typepassword namenewPassword classform-control password placeholderNew Password value> div classinvalid-feedback new-password> span classinvalid-new-password>/span> /div> /div> div classform-group> label classsr-only forconfirmNewPassword value>Confirm New Password/label> input typepassword nameconfirmNewPassword classform-control password placeholderConfirm New Password value> div classinvalid-feedback new-password> span classinvalid-new-password>/span> /div> /div> div classform-group> label classsr-only forchangePasswordButton>Change Password Button/label> button idbutton-change-password typebutton classbtn btn-primary float-right clearfix>Change Password/button> /div> /form> /div> /div> /div> /div> /div> div classreset-password page> div classcontainer reset-password content-spacer-top> div classrow> div classcontainer col-md-10> div idalert-password-reset-ok classalert alert-success rolealert styledisplay:none> Your password was successfully updated. Please click a href#report>here/a> to see your report. /div> div idalert-password-reset-invalid classalert alert-danger rolealert styledisplay:none> span idalert-password-reset-invalid-msg>/span> /div> div idreset-password> form idform-reset-password classform-reset-password form-wrapper form-narrow styleoverflow: auto;> h3> span>Reset password/span> hr classw-50 to-left mb-0> /h3>p classmargin-bottom-2rem>/p>p> /p>div classform-group> label classsr-only forresetPassword value>New Password/label> input typepassword nameresetPassword classform-control password placeholderNew Password value> div classinvalid-feedback new-password> span classinvalid-new-password>/span> /div> /div> div classform-group> label classsr-only forconfirmResetPassword value>Confirm New Password/label> input typepassword nameconfirmResetPassword classform-control password placeholderConfirm New Password value> div classinvalid-feedback new-password> span classinvalid-new-password>/span> /div> /div> div classform-group> label classsr-only forchangePasswordButton>Reset Password Button/label> button idbutton-reset-password typebutton classbtn btn-primary float-right clearfix>Update Password/button> /div> /form> /div> /div> /div> /div> /div> div classverified page> div classcontainer> div classrow justify-content-center content-spacer-top> div idcol-md-10> div idalert-verified classalert alert-success rolealert> Your account email has been verified. Please a href#login>login/a> to access your report. /div> /div> /div> /div> /div> div classpasswordResetConfirmed page> div classcontainer> div classrow justify-content-center content-spacer-top> div idcol-md-10> div idalert-verified classalert alert-success rolealert> Your password has been successfully reset. Please a href#login>login/a> with your new password to view your report. /div> /div> /div> /div> /div> div classnotVerified page> div classcontainer content-spacer-top> div classrow justify-content-center> div classcol-md-10> div idalert-not-verified-error classalert alert-danger d-none rolealert> Your account could not be verified. Please enter your email address to receive a verification email. /div> div idalert-not-verified classalert alert-danger d-none rolealert> You still need to verify your account. Please enter the email address you used to sign up and we will send you a new verification email. /div> /div> /div> div classrow justify-content-center> div classcol-md-10 idverify-account> div idalert-account-not-found classalert alert-danger d-none rolealert> Email not found. Please enter the email you used to sign up. /div> div classcontainer> form idform-verify-account classform-verify-account form-wrapper form-narrow styleoverflow: auto;> h3> span>Verify your email/span> hr classw-50 to-left mb-0> small classmargin-bottom-2rem>Please provide your email/small> /h3>p classmargin-bottom-2rem>/p> div classform-group mt-4> label classsr-only foremail>Email/label> input typeemail nameverifyEmail classform-control email placeholderEmail required> div classinvalid-feedback> Not a valid email address /div> /div> div classform-group> label classsr-only forbutton-resend-verification-email>Resend/label> button idbutton-resend-verification-email typesubmit classbtn btn-primary float-right>Resend/button> /div> /form> /div> /div> /div> /div> /div> div classresetInvalid page> div classcontainer content-spacer-top> div classrow> div classcol-md-12> div idalert-reset-invalid-error classalert alert-danger rolealert> Reset request is no longer valid. Click a href#forgot-password>here/a> to request another reset email. /div> /div> /div> /div> /div> div classconfirmSend page> div classcontainer content-spacer-top> div classrow justify-content-center> div classcol-md-12> div idalert-sent classalert alert-success rolealert> span idalert-sent-msg>/span> /div> /div> /div> /div> /div> div classproduct page> div namebanner classbg-white overlay overlay-op-6 text-center px-3 py-5 py-lg-10 flex-valign bg-img blazy-bg b-loaded stylebackground-position-x: center; background-position-y: 30%; background-image: url(assets/img/screenshots_lg.png);> h2 classdisplay-4 text-white data-animate-delay0.2 styleanimation-delay: 0.2s;> span classfont-weight-bold>Model from Real Sciencebr>+br>Your Genomic Databr>br> Personalized Alzheimer’s Disease Risk/span> /h2> !-- h3 classtext-grey font-weight-normal data-animate-delay0.35 styleanimation-delay: 0.35s;> Kickstart your next web project with AppStrap! /h3> --> hr classhr-primary hr-lg w-20 mx-auto my-4 data-animate-delay0.45 styleanimation-delay: 0.45s;> div nameproduct-pricing classcontainer text-white mt-3 mb-4 text-center> /div> div> a href#create-account classbutton-signup btn btn-primary btn-rounded btn-xl py-lg-3 px-lg-6 text-uppercase font-weight-bold>Get Started/a> /div> /div> div classcontainer w-90> hr classhr-lg mt-7 mb-8 w-10 mx-auto hr-primary> h3 classtext-center text-uppercase font-weight-bold my-0> Why should I order this analysis? /h3> hr classmb-4 w-50 mx-auto> div classrow col-md-12> div classcol-md-5 d-flex align-items-center> img srcassets/img/why-wordCloud.jpg classimg-fluid mt-4 mb-4 altPower in Knowledge> /div> div classcol-md-7 d-flex align-items-center> div> h4 classfont-weight-bold text-uppercase text-primary my-3> POWER IN KNOWLEDGE /h4> p>Although symptoms of Alzheimers disease usually onset in the later stages of life, the brain begins changing 10-20 years before. The age of onset for an individual with low risk versus one with high risk can vary by span classfont-weight-bold>as much as 15 years or more/span> based on research conducted by UCSF and UCSD./p> p>Understanding the latest research and similarities of your genetic profile to research cohorts can help continue your journey in learning about your genetic risks for Alzheimers Disease./p> p>Once you know more about the risk of Alzheimers disease, you can make more informed lifestyle changes. Although these have not yet been clinically validated or formally approved by the medical community, some early research studies suggest lifestyle changes can improve outcomes for those with Alzheimers disease, including physical exercise, diet, social connections and intellectual activity. Learn more at a href/ target\_new\>Alzheimers Association/a>./p> /div> /div> /div> /div> div classcontainer w-90> hr classhr-lg mt-7 mb-8 w-10 mx-auto hr-primary> h3 classtext-center text-uppercase font-weight-bold my-0> Beyond APOE /h3> hr classmb-4 w-50 mx-auto> div classrow col-md-12> div classcol-md-12 d-flex align-items-center> div> h4 classfont-weight-bold text-uppercase text-primary my-3> How are we different from other APOE based risk analyses? /h4> p>Dash Genomics offers the ONLY Alzheimers disease risk algorithm that goes beyond the APOE gene./p>p> /p>p>Its span classfont-weight-bold text-primary>more EXTENSIVE/span>. Other APOE offerings only report the risk based on the genotypes of 2 loci (rs429358 and rs7412) within the APOE gene. Dash Genomics considers not only these 2 loci but also looks into span classfont-weight-bold>as many as 600,000 loci/span> in your genome that may contribute to the genetic risk of Alzheimers disease based on the research model./p>p> /p>p>Its span classfont-weight-bold text-primary>QUANTITATIVE/span>. Only Dash Genomics analysis estimates the risk of Alzheimers disease as a function of age. At any given age, Dash Genomics provides the risk of Alzheimers disease onset by this age (span classfont-weight-bold>Cumulative risk/span>) and within the year of the age (span classfont-weight-bold>Instantaneous risk/span>) based on the research model. The analysis also estimates the percentage of people who have lower/higher risk than you (span classfont-weight-bold>Polygenic Hazard Score (PHS) percentile/span>)./p> p>Its span classfont-weight-bold text-primary>INTUITIVE/span>. Dash Genomics Alzheimers risk report provides charts, tables and quick tips to help you understand different aspects of your risk profile easily. See a href#demoreport>a demo report/a>./p> /div> /div> /div> div classrow mt-3> div classcontainer stylemin-width: 666px;> table classtable-sm table-striped table-hover stylewidth: 90% aligncenter> tr> th classw-30 border-bottom border-top text-left colspan4>/th> th classw-35 border-bottom border-top text-center colspan4>Dash Genomics/th> th classw-35 border-bottom border-top text-center colspan4>Other APOE Offerings/th> /tr> tr classborder-bottom> td classw-30 text-left font-weight-bold colspan4>Approach/td> td classw-35 text-center colspan4>Polygenic Hazard Score (PHS)br>Genomewide Loci are evaluated./td> td classw-35 text-center colspan4>Genotypes of two loci of the APOE gene/td> /tr> tr classborder-bottom> td classw-30 text-left font-weight-bold colspan4>Loci in Consideration/td> td classw-35 text-center colspan8>/td> /tr> tr classborder-bottom> td classw-30 text-left font-weight-bold colspan4> rs425893 (APOE)/td> td classw-35 text-center colspan4>i classfas fa-check icon-1.5x text-primary>/i>/td> td classw-35 text-center colspan4>i classfas fa-check icon-1.5x text-primary>/i>/td> /tr> tr classborder-bottom> td classw-30 text-left font-weight-bold colspan4> rs7412 (APOE)/td> td classw-35 text-center colspan4>i classfas fa-check icon-1.5x text-primary>/i>/td> td classw-35 text-center colspan4>i classfas fa-check icon-1.5x text-primary>/i>/td> /tr> tr classborder-bottom> td classw-30 text-left font-weight-bold colspan4> 600,000 loci in the genome/td> td classw-35 text-center colspan4>i classfas fa-check icon-1.5x text-primary>/i>/td> td classw-35 text-center colspan4>i classfas fa-dash icon-1.5x text-primary>/i>/td> /tr> tr classborder-bottom> td classw-30 text-left font-weight-bold colspan4>Report/td> td classw-35 text-center colspan8>/td> /tr> tr classborder-bottom> td classw-30 text-left font-weight-bold colspan4> APOE subtypesbr> (APOE-e4 variant counts)/td> td classw-35 text-center colspan4>i classfas fa-check icon-1.5x text-primary>*/i>/td> td classw-35 text-center colspan4>i classfas fa-check icon-1.5x text-primary>/i>/td> /tr> tr classborder-bottom> td classw-30 text-left font-weight-bold colspan4> Cumulative Risk/td> td classw-35 text-center colspan4>i classfas fa-check icon-1.5x text-primary>/i>/td> td classw-35 text-center colspan4>i classfas fa-dash icon-1.5x text-primary>/i>/td> /tr> tr classborder-bottom> td classw-30 text-left font-weight-bold colspan4> Instantaneous Risk/td> td classw-35 text-center colspan4>i classfas fa-check icon-1.5x text-primary>/i>/td> td classw-35 text-center colspan4>i classfas fa-dash icon-1.5x text-primary>/i>/td> /tr> tr classborder-bottom> td classw-30 text-left font-weight-bold colspan4> AZsub>50/sub> Age/td> td classw-35 text-center colspan4>i classfas fa-check icon-1.5x text-primary>/i>/td> td classw-35 text-center colspan4>i classfas fa-dash icon-1.5x text-primary>/i>/td> /tr> tr classborder-bottom> td classw-30 text-left font-weight-bold colspan4> PHS Percentile/td> td classw-35 text-center colspan4>i classfas fa-check icon-1.5x text-primary>/i>/td> td classw-35 text-center colspan4>i classfas fa-dash icon-1.5x text-primary>/i>/td> /tr> /table> div classcontainer w-90 mt-3> p>* The feature will be made available to all Dash Genomics users soon./p> /div> /div> /div> /div> div classcontainer w-90> hr classhr-lg mt-7 mb-8 w-10 mx-auto hr-primary> h3 classtext-center text-uppercase font-weight-bold my-0> Your report will present /h3> hr classmb-4 w-50 mx-auto> div classrow col-md-12> div classcol-md-6 d-flex align-items-center> img srcassets/img/rs_table.png classimg-fluid mt-4 mb-4 altresult summary table> /div> div classcol-md-6 bg-light d-flex align-items-center> div> h5 classtext-primary text-center text-uppercase font-weight-bold my-0 mt-4> Summary Section /h5> hr classmb-4 w-50 mx-auto> p>Summarize the most relevant information about your Alzheimers disease risk, including:/p> ul> li>Cumulative risk by the current agesup>*/sup>/li> li>Instantaneous risk at the current agesup>*/sup>/li> li>AZsub>50/sub>Age/li> li>Polygenic Hazard Score (PHS) percentile/li> /ul> br> p classtext-right mb-4>small>sup>*/sup>For people younger than 60, the risk will be based on the age of 65./small>/p> /div> /div> /div> div classrow col-md-12> div classcol-md-6 bg-light d-flex align-items-center> div> h5 classtext-primary text-center text-uppercase font-weight-bold my-0 mt-4> Cumulative Risk Section /h5> hr classmb-4 w-50 mx-auto> p classmb-4>Based on the similarity between your genetic information to that of the research cohort analyzed, learn about your risk of developing Alzheimer’s Disease by a specific age -- your cumulative risk. Compare your information to the average for different age groups./p> /div> /div> div classcol-md-6 d-flex align-items-center> img srcassets/img/cr_figure.png classimg-fluid mt-4 mb-4 altinstantaneous figure> /div> /div> div classrow col-md-12> div classcol-md-6 d-flex align-items-center> img srcassets/img/ir_figure.png classimg-fluid mt-4 mb-4 altinstantaneous figure> /div> div classcol-md-6 bg-light d-flex align-items-center> div> h5 classtext-primary text-center text-uppercase font-weight-bold my-0 mt-4> Instantaneous Risk Section /h5> hr classmb-4 w-50 mx-auto> p classmb-4>Understand your risk of developing Alzheimer’s Disease at a specific age - your instantaneous risk. Again, this estimate is based on the similarity between your genetic information to that of the research cohort analyzed. Compare your information to the average for different age groups./p> /div> /div> /div> div classrow col-md-12> div classcol-md-6 bg-light d-flex align-items-center> div> h5 classtext-primary text-center text-uppercase font-weight-bold my-0 mt-4> 5-year Risk Sectionsup>*/sup> /h5> hr classmb-4 w-50 mx-auto> p classmb-4>Want to zoom into the next few years? Based on your current age and genetic profile, explore your risk of developing Alzheimer’s Disease in the next 5 years. This profile will evolve over time./p> br> p classtext-right mb-4>small>sup>*/sup>Only available for people who are older than 60./small>/p> /div> /div> div classcol-md-6 d-flex align-items-center> img srcassets/img/5yr_figure.png classimg-fluid mt-4 mb-4 altinstantaneous figure> /div> /div> div classrow col-md-12> div classcol-md-6 d-flex align-items-center> img srcassets/img/phs_figure.png classimg-fluid mt-4 mb-4 altphs percentile figure> /div> div classcol-md-6 bg-light d-flex align-items-center> div> h5 classtext-primary text-center text-uppercase font-weight-bold my-0 mt-4> Polygenic Hazard Score (PHS) Percentile /h5> hr classmb-4 w-50 mx-auto> p classmb-4>Compare your personalized risk to the general population. Your Polygenic Hazard Score (PHS) percentile presents the percentage of people in the general population who have equal or lower age-specific risks for developing the late-onset Alzheimers disease than you based on the research model./p> br> /div> /div> /div> br> h3 classtext-center text-primary>sup>i classfa fa-file-alt icon-2x>/i>/sup> i>a href#demoreport/#Introduction>View a demo report/a>/i>/h3> hr classhr-lg mt-7 mb-8 w-10 mx-auto hr-primary> div classcontainer namehowItWorks> /div> hr classhr-lg mt-7 mb-8 w-10 mx-auto hr-primary> div classcontainer idproductLimitation> h3 classtext-center text-uppercase font-weight-bold my-0> Limitations /h3> hr classmb-4 w-50 mx-auto> div classrow col-md-12 mb-5 namelimitation-content> /div> /div> hr classhr-lg mt-7 mb-8 w-10 mx-auto hr-primary> div classcontainer idproductDisclaimer> h3 classtext-center text-uppercase font-weight-bold my-0> Disclaimers /h3> hr classmb-4 w-50 mx-auto> div classrow col-md-12 mb-5 namedisclaimer-content> /div> /div> /div> /div> div classfaq page> div classcontainer page-header border-0> h1 aligncenter>Fsmall>requently/small> Asmall>sked/small> Qsmall>uestions/small> /h1> hr classw-75 mx-auto m-4> /div> div classrow mt-4> div idfaq classcol-md-12> div classcontainer panel-group idaccordion> div classpanel panel-default namefaq-list> /div> /div> /div> /div> /div> div classtos page> div classcontainer page-header border-0> h1 aligncenter nametos-list-title> /h1> hr classw-75 mx-auto m-4> h3 alignright>small>i nametos-list-lastupdate>/i>/small> /h3>/div> div classrow mt-4> div idtos classcol-md-12> div classcontainer panel-group idaccordion> div classpanel panel-default nametos-list> /div> /div> /div> /div> /div> div classpp page> div classcontainer page-header border-0> h1 aligncenter namepp-list-title> /h1> hr classw-75 mx-auto m-4> h3 alignright> small>i namepp-list-lastupdate>/i>/small> /h3>/div> div classrow mt-4> div idpp classcol-md-12> div classcontainer panel-group idaccordion> div classpanel panel-default namepp-list> /div> /div> /div> /div> /div> div classreport page> div classcontainer> div classrow> div classcol-md-12> div classcontainer sticky> !--@todo: replace with company copyright details--> br> ul classreportIndex-list-inline idreportIndex> li classlist-inline-item mx-0>a namereportInternalLinks href#report/#Introduction>Introduction/a> | /li> li classlist-inline-item mx-0>a namereportInternalLinks href#report/#Limitations>Limitations/a> | /li> li classlist-inline-item mx-0>a namereportInternalLinks href#report/#Disclaimers>Disclaimers/a> | /li> li classlist-inline-item mx-0>a namereportInternalLinks href#report/#Science>Science/a>/li> br> li classlist-inline-item mx-0>a namereportInternalLinks href#report/#ResultSummary>Analysis Summary/a> | /li> li classlist-inline-item mx-0>a namereportInternalLinks href#report/#CumulativeRisk>Cumulative Risk/a> | /li> li classlist-inline-item mx-0>a namereportInternalLinks href#report/#InstantaneousRisk>Instantaneous Risk/a>/li> li classlist-inline-item mx-0 nameFiveYearRisk> | a namereportInternalLinks href#report/#FiveYearRiskSection>5 Year Risk/a>/li> br> li classlist-inline-item mx-0>a namereportInternalLinks href#report/#PHS>Polygenic Hazard Score Percentile/a> | /li> li classlist-inline-item mx-0 nameAPOETag>a namereportInternalLinks href#report/#APOE>APOE Status/a> | /li> li classlist-inline-item mx-0>a namereportInternalLinks href#report/#NextStep>Next Steps/a>/li> /ul> /div> div classcontainer text-right mt-3> a hrefjavascript:window.print()>i classfa fa-print icon-2x text-primary aria-hiddentrue>/i>/a> /div> div classcontainer idIntroduction> div data-animatefadeIn data-animate-duration0.8 styleanimation-duration: 0.8s; classanimated animated-done> hr classhr-lg mt-7 mb-8 w-10 mx-auto hr-primary> h3 classtext-left text-uppercase font-weight-bold mt-0> Introduction /h3> hr classmb-4 w-50 to-left> p classtext-justify> Dementia affects around 50 million people worldwide, with nearly 10 million new cases each year. Alzheimer’s disease is the most common form of dementia, accounting for 60-80% of cases. The condition is often associated with loss of memory, confusion, and the decline of other cognitive functions. Alzheimer’s disease can be influenced by a number of factors including genetics, lifestyle and environment. /p> p classtext-justify> Late Onset Alzheimer’s disease is the most common form of Alzheimer’s disease, which develops after the age of 65. Research suggests that by 80 years of age, over 10.3% of individuals face the onset of Alzheimers disease. /p> p classfont-justify> Our partner, a namehealthLytixLink>HealthLytix/a>, a precision health company based in San Diego, has developed a new model, based on research from University of California San Diego and University of California San Francisco, that estimates your personalized risk of developing Alzheimer’s disease as a function of age based on your genetic information (subject to the limitations described below). Dash Genomics has worked with a namehealthLytixLink>HealthLytix/a> to bring this analysis to anyone who has had their genetic information provided by either a name23andmeLink>23andMe/a> or a nameancestryLink>Ancestry.com/a>. /p> /div> /div> div classcontainer idLimitations> div data-animatefadeIn data-animate-duration0.8 styleanimation-duration: 0.8s; classanimated animated-done> hr classhr-lg mt-7 mb-8 w-10 mx-auto hr-primary> h3 classtext-left text-uppercase font-weight-bold mt-0> Limitations /h3> hr classmb-4 w-50 to-left> div classrow container namelimitation-content> /div> /div> /div> div classcontainer idDisclaimers> div data-animatefadeIn data-animate-duration0.8 styleanimation-duration: 0.8s; classanimated animated-done> hr classhr-lg mt-7 mb-8 w-10 mx-auto hr-primary> h3 classtext-left text-uppercase font-weight-bold mt-0> Disclaimers /h3> hr classmb-4 w-50 to-left> div classrow container namedisclaimer-content> /div> /div> /div> div classcontainer idScience> div data-animatefadeIn data-animate-duration0.8 styleanimation-duration: 0.8s; classanimated animated-done> hr classhr-lg mt-7 mb-8 w-10 mx-auto hr-primary> h3 classtext-left text-uppercase font-weight-bold mt-0> Science - How Does it Work? /h3> hr classmb-4 w-50 to-left> p classtext-justify> u>Your Genetic Data./u> To estimate your Alzheimers disease risk, we imported your data from a namedataSource>/a> and analyzed your data using the model developed by a namehealthLytixLink>HealthLytix/a>. This model is based on research that originally looked at 33 loci near 28 genes and the list of genes/loci evaluated as part of this research can be found in the a hrefhttp://journals.plos.org/plosmedicine/article/figure?id10.1371/journal.pmed.1002258.t002 target_new>work/a> published by a nameucsdLink>UC San Diego/a> and a nameucsfLink>UC San Francisco/a>. The HealthLytix team has since expanded the algorithm to look at up to approximately 600,000 high quality loci that are commonly found in 23andMe and Ancestry.com data files. span nameancestryImputeTag>In certain cases, because a namedataSource>/a> data might not cover all the genotypes of the critical genetic loci that are used in the algorithm or because it contains known or perceived errors, we impute (infer the values for) certain genetic loci based on other parts of your genome./span> /p> p classtext-justify> u>Research Model./u> a namehealthLytixLink>HealthLytix/a>’s proprietary algorithm used for this analysis was developed based on research from a nameucsdLink>UC San Diego/a> and a nameucsfLink>UC San Francisco/a> to assess age-dependent risk of developing Alzheimer’s disease. While previous research has identified certain genetic markers associated with Alzheimer’s disease (such as APOE), the genetic markers newly identified by our partner researchers have never before been used to estimate risk. /p> p classtext-justify> This analysis estimates individual genetic risk of Alzheimer’s disease based on a persons genetic markers and age by looking at the similarities between your genetic profile and the risk of genetic profiles in the patient research cohort analyzed. You can find details about the research team’s analysis, including methodology and findings, in a namepaperLink>their published research/a>. /p> /div> /div> div classcontainer idResultSummary> div data-animatefadeIn data-animate-duration0.8 styleanimation-duration: 0.8s; classanimated animated-done> hr classhr-lg mt-7 mb-8 w-10 mx-auto hr-primary> h3 classtext-left text-uppercase font-weight-bold mt-0> Analysis Summary /h3> hr classmb-4 w-50 to-left> table classtable-sm table-striped table-hover stylewidth: 90% aligncenter> tr classw-100> th colspan3 classw-50> img srcassets/img/logo.png classimg-fluid logo> br> p>small>Polygenic Alzheimers Disease Risk/small>/p> /th> th classw-50 text-right align-bottom> p nameprocessed-on>/p> /th> /tr>tr> /tr>tr> th classw-100 border-bottom border-top colspan4>Personal Information/th> /tr> tr classborder-bottom align-bottom> td classw-20 text-right>small>Name: /small>/td> td classw-30 nameclient-name>b>John Dash/b>/td> td classw-20 text-right border-left>small>Age: /small>/td> td classw-30 namecurrent-age>b>65/b>/td> /tr> tr classborder-bottom align-bottom> td classw-20 text-right>small>Data source: /small>/td> td classw-30 colspan3 namedataSource>b>23andme/b>/td> !-- td classw-20 text-right border-left>small>Analysis : small>/td> --> !-- td classw-30 namedata-qc>b classtext-success>Pass/b>/td> --> /tr> /table> br> table classtable-sm table-striped table-hover stylewidth: 90% aligncenter> tr> th classw-100 border-bottom border-top colspan4>Summary/th> /tr> tr classborder-bottom> td classw-50 text-right namecrtitle>Cumulative Risk by the Current Age sup>1/sup> : /td> td classw-50 text-center namecurrentCR>b>5.0%b>/b>/b>/td> !-- td classw-40 colspan2 >/td> --> /tr> tr classborder-bottom> td classw-50 text-right nameirtitle>Instantaneous Risk at the Current Age sup>2/sup> : /td> td classw-50 text-center namecurrentIR>b>7.0%/b>/td> !-- td classw-40 colspan2>/td> --> /tr> tr classborder-bottom> td classw-50 text-right>AZsub>50/sub> Age sup>3/sup> : /td> td classw-50 text-center nameaz50age>b>70/b>/td> !-- td classw-40 colspan2>/td> --> /tr> tr classborder-bottom> td classw-50 text-right>Polygenic Hazard Score Percentile sup>4/sup> : /td> td classw-50 text-center namephs>b>50b>/b>/b>/td> !-- td classw-40 colspan2 >/td> --> /tr> tr classborder-bottom nameAPOETag> td classw-50 text-right>APOE status span classd-none idimputedTag1>(imputed) /span>sup> 5/sup> : /td> td classw-50 text-center nameapoe-status colspan3>b>APOE-ε2/APOE-ε2b>/b>/b>/td> /tr> /table> div classcontainer w-90 mt-4 mb-4> ol classlist mb-3 sup_n> li classlist-item>a namereportInternalLinks href#report/#CumulativeRisk> Cumulative Risk: /a>Risk of onset of Alzheimer’s disease by span nameageDescription>your current age/span>./li> li classlist-item>a namereportInternalLinks href#report/#InstantaneousRisk> Instantaneous Risk: /a>Risk of onset of Alzheimer’s disease within the year of span nameageDescription>your current age/span>, if you have not already developed the condition./li> li classlist-item>a namereportInternalLinks href#report/#CumulativeRisk> AZsub>50/sub> Age: /a>The age when your cumulative risk of onset of Alzheimer’s disease exceeds 50%./li> li classlist-item>a namereportInternalLinks href#report/#PHS> Polygenic Hazard Score Percentile: /a>The percentage of people in the general population who are estimated to have equal or lower age-specific risks for developing late-onset Alzheimers disease than you, based on the research model./li> li classlist-item nameAPOETag>a namereportInternalLinks href#report/#APOE> APOE status: /a>The combination of 2 copies of the APOE forms span classd-none idimputedTag2>(imputed) /span>in your genome./li> /ol> /div> p classtext-justify> Individual genetic risk of Alzheimer’s disease is quantified based on your genetic markers and age. We use the proprietary research model to look at the similarities between your genetic profile and the average risk in the group analyzed in the research. Note that this model is unique to Late-Onset Alzheimer’s disease, which by definition is the onset after the age of 65. In this report, we include risk information from the age of 60, which may be the starting point of decline. Additionally, your instanteous probabilities of onset will change each year based on whether or not you’ve experienced any symptoms. /p> p classfont-italic> Find more details about the research team’s analysis, including methodology and findings, in their a hrefhttp://journals.plos.org/plosmedicine/article?id10.1371/journal.pmed.1002258 target_new>published research papers/a>. At any point, you can reference the a href#product>Product Overview/a> to learn more about Alzheimer’s disease and this model’s science and limitations. /p> /div> /div> div classcontainer idCumulativeRisk> div data-animatefadeIn data-animate-duration0.8 styleanimation-duration: 0.8s; classanimated animated-done> hr classhr-lg mt-7 mb-8 w-10 mx-auto hr-primary> h3 classtext-left text-uppercase font-weight-bold mt-0> Cumulative Risk /h3> hr classmb-4 w-50 to-left> h5 classtext-justify> Cumulative risk is a measure of the probability of onset of Alzheimer’s disease by a certain age based on the similarity of your genetic profile to the research population. /h5> div classcontainer w-95 form-control-rounded rounded-20 bg-light mt-4 mb-4> div classcontainer pt-3 pb-3 text-justify> h3>Q: small>b>What does cumulative risk mean?/b>/small> /h3> p>Cumulative risk is measured by looking at the number of incidences (i.e. onset of Alzheimer’s disease) among people with similar genetic profiles to you in the research cohort studied over a specific time period (e.g. 70 years). As a simplified example, let’s assume that the research cohort studied had 1000 people with the same relevant genetic profile as you. If, upon analyzing the number of occurrences of onset of Alzheimers disease up until the age of 70, we only observed one person in this group who had the onset of Alzheimers disease, then the incidence ratio to the total population at risk over 70 years is 1/1000, which represents a cumulative risk of onset of Alzheimers disease by the age of 70 at 0.1%. /p> /div> /div> p classtext-justify mb-4> The table and figure below provide span classfont-weight-bold>(a)/span> your cumulative risk (in span classtext-red>red/span>) of developing Alzheimer’s disease at any point up to and including a certain age based on your genetic profile and its similarity to the research cohort and span classfont-weight-bold>(b)/span> the baseline or average cumulative risk (in span classtext-blue>blue/span>) based on the average of the research population as a whole. /p> /div> div classcontainer mb-4 stylewidth: 80%; min-width: 666px> br> canvas classd-none idcr_canvas_demo>/canvas> canvas classd-none idcr_canvas>/canvas> br> /div> div classcontainer w-90> div classrow> div classcol-md-6> table classtable-sm table-striped table-hover mt-3 aligncenter> tr idCumulativeRiskTableLeft aligncenter> th classw-10 col-md-2>Age (years)/th> th classw-45 col-md-5>Baseline Cumulative Risk (%)/th> th classw-45 col-md-5>Cumulative Risk Based on Your Profile (%)/th> /tr> tbody nameCumulativeRiskTableLeft> /tbody> /table> /div> div classcol-md-6> table classtable-sm table-striped table-hover mt-3 aligncenter> tr idCumulativeRiskTableRight aligncenter> th classw-10 col-md-2>Age (years)/th> th classw-45 col-md-5>Baseline Cumulative Risk (%)/th> th classw-45 col-md-5>Cumulative Risk Based on Your Profile (%)/th> /tr> tbody nameCumulativeRiskTableRight> /tbody> /table> /div> /div> /div> /div> div classcontainer idInstantaneousRisk> div data-animatefadeIn data-animate-duration0.8 styleanimation-duration: 0.8s; classanimated animated-done> hr classhr-lg mt-7 mb-8 w-10 mx-auto hr-primary> h3 classtext-left text-uppercase font-weight-bold mt-0> Instantaneous Risk /h3> hr classmb-4 w-50 to-left> h5 classtext-justify> Instantaneous Risk is a measure of the probability of onset of Alzheimer’s disease within a given year, assuming you have not yet experienced the disease. /h5> div classcontainer w-95 form-control-rounded rounded-20 bg-light mt-4 mb-4> div classcontainer pt-3 pb-3 text-justify> h3>Q: small>b>What does the instantaneous risk mean?/b>/small> /h3> p>Instantaneous risk is also called the annualized incidence rate, which represents the estimated proportion (in percent) of individuals with a similar genetic profile and age as yours who have not yet developed Alzheimer’s disease but will develop it within the year of each given age. /p> !-- p>The incidence rate is more analogous to the speed of a car, which is typically expressed in miles per hour. Time has to elapse to measure a cars speed, but we dont have to wait a whole hour; we can glance at the speedometer to see the instantaneous rate of travel. Rather than measuring total incidence per se, the instantaneous risk rate measures the rate at which new cases of Alzheimers disease occur per unit of time (annualized in our case). --> p classtext-justify> For example, if you are a nameage>/a> years old, the expected incidence rate for your age group as a whole (the baseline risk) is a namebaselineInstantaneousRisk>/a>, meaning a namebaselineInstantaneousRisk>/a> of people in this age group generally experience the onset of Alzheimer’s disease during the age of a nameage>/a>. /p> p classtext-justify> With this model, assuming that you are a nameage>/a> years old and have not already developed Alzheimer’s disease, for people with similar genetic profiles as yours, the probability of onset of Alzheimer’s disease in the current year is instead estimated to be a namepersonalizedInstantaneousRisk>/a>. /p> /div> /div> p classtext-justify mb-4> The table and figure below provide span classfont-weight-bold>(a)/span> your instantaneous risk (in span classtext-red>red/span>) or probability of developing Alzheimer’s disease during each given age calculated based on your genetic profile and its similarity to the research cohort and span classfont-weight-bold>(b)/span> the baseline or average instantaneous risk (in span classtext-blue>blue/span>) based on the average of the research population as a whole. /p> /div> div classcontainer mb-4 stylewidth: 80%; min-width: 666px> br> canvas classd-none idir_canvas_demo>/canvas> canvas classd-none idir_canvas>/canvas> br> /div> div classcontainer w-90> div classrow> div classcol-md-6> table classtable-sm table-striped table-hover mt-3 aligncenter> tr idInstantaneousRiskTableLeft aligncenter> th classw-10 col-md-2>Age (years)/th> th classw-45 col-md-5>Baseline Instantaneous Risk (%)/th> th classw-45 col-md-5>Instantaneous Risk Based on Your Genetic Profile (%)/th> /tr> tbody nameInstantaneousRiskTableLeft> /tbody> /table> /div> div classcol-md-6> table classtable-sm table-striped table-hover mt-3 aligncenter> tr idInstantaneousRiskTableRight aligncenter> th classw-10 col-md-2>Age (years)/th> th classw-45 col-md-5>Baseline Instantaneous Risk (%)/th> th classw-45 col-md-5>Instantaneous Risk Based on Your Genetic Profile (%)/th> /tr> tbody nameInstantaneousRiskTableRight> /tbody> /table> /div> /div> /div> /div> div classcontainer idFiveYearRiskSection nameFiveYearRisk> div data-animatefadeIn data-animate-duration0.8 styleanimation-duration: 0.8s; classanimated animated-done> hr classhr-lg mt-7 mb-8 w-10 mx-auto hr-primary> h3 classtext-left text-uppercase font-weight-bold mt-0> 5-Year Risk /h3> hr classmb-4 w-50 to-left> p classtext-justify> span name5yrrintro>The graph below provides your estimated risk over the next five years of developing Alzheimer’s disease./span> It is generated through our research model and by combining the estimates for risk of onset by or at a certain age -- based on looking at the similarities between your genetic profile and the risk of genetic profiles in the patient research cohort analyzed. In this chart, your initial risk is reset to 0, assuming that you have not had any symptoms of Alzheimers disease by the current age. /p> /div> div classcontainer stylewidth: 80%; min-width: 666px> br> canvas classd-none id5yrr_canvas>/canvas> canvas classd-none id5yrr_canvas_demo>/canvas> br> /div> /div> div classcontainer idPHS> div data-animatefadeIn data-animate-duration0.8 styleanimation-duration: 0.8s; classanimated animated-done> hr classhr-lg mt-7 mb-8 w-10 mx-auto hr-primary> h3 classtext-left text-uppercase font-weight-bold mt-0> Polygenic Hazard Score (PHS) Percentile /h3> hr classmb-4 w-50 to-left> h5 classtext-justify> Polygenic Hazard Score(PHS) for late-onset Alzheimer’s disease is a new polygenic model for determining the risk of Alzheimers disease that accounts for multiple genetic loci (beyond APOE status) and their weights associated with risk based on research cohorts. /h5> div classcontainer w-95 form-control-rounded rounded-20 bg-light mt-4 mb-4> div classcontainer pt-3 pb-3 text-justify> h3>Q: small>b>What does a Polygenic Hazard Score (PHS) percentile mean?/b>/small> /h3> p>Your Polygenic Hazard Score (PHS) percentile, ranging from 1 to 100, represents the percentage of people in the general population who have equal or lower age-specific risks for developing the late-onset Alzheimers disease than you based on the research model. For an individual whose PHS percentile is 1, it means that at any given age, only 1% of people are estimated to have an equal or lower risk of developing the Alzheimers disease than the individual. A PHS percentile of 99 implies that 99% of people are estimated to have an equal or lower risk than such individual. An individual with a high PHS percentile is estimated to have a higher risk than the one with a low PHS percentile, at any given age. /p> /div> /div> p classtext-justify mb-4> Your Polygenic Hazard Score is span classfont-weight-bold h3 namephs>75/span>. br> This means span classfont-weight-bold>span namephs>25%/span>%/span> of the population is estimated to have a lower or equal risk than you of developing Alzheimer’s disease based on the research model (See the figure below). /p> !-- p> This means span classfont-weight-bold>span namephs>15/span>%/span> of the population has a lower or equal risk than you of developing Alzheimer’s disease. /p> --> /div> div classcontainer mb-4 stylewidth: 80%; min-width: 666px> br> div classtext-center namephsChart>/div> br> p classtext-center mb-4> i classfas fa-male icon-1x text-primary>/i>: Population with lower risk than you; i classfas fa-male icon-1x text-warning>/i>: Population with higher risk than you; i classfas fa-male icon-1x text-blue>/i>: You. /p> /div> /div> div classcontainer idAPOE nameAPOETag> div data-animatefadeIn data-animate-duration0.8 styleanimation-duration: 0.8s; classanimated animated-done> hr classhr-lg mt-7 mb-8 w-10 mx-auto hr-primary> h3 classtext-left text-uppercase font-weight-bold mt-0> APOE status /h3> hr classmb-4 w-50 to-left> h5 classtext-justify> The APOE gene provides instructions for making a protein called apolipoprotein E. This protein combines with fats (lipids) in the body to form molecules called lipoprotein, which help control the levels of cholesterol and fats in the blood. /h5> div classcontainer w-95 form-control-rounded rounded-20 bg-light mt-4 mb-4> div classcontainer pt-3 pb-3 text-justify> h3>Q: small>b>What are the different APOE forms?/b>/small> /h3> p>The APOE gene has three relatively common forms defined by two SNPs, rs429358 and rs7412. These forms are known as APOE-ε2 (APOE-e2), APOE-ε3 (APOE-e3), and APOE-ε4 (APOE-e4), and encodes the proteins APOE2, APOE3, and APOE4 respectively (See the table below). APOE-ε3 is the most common formsup>a namereportInternalLinks href#report/#reference> 1/a>/sup>, followed by APOE-ε4 and APOE-ε2. /p> div classcontainer w-80 my-3> p>span classfont-weight-bold>Table: /span>Different APOE genotypes and forms/p> table classtable-sm table-striped table-hover w-75 aligncenter> tr classborder-bottom border-top text-center font-weight-bold> th>rs429358/th> th>rs7412/th> th>APOE Form/Subtype/th> th>Encoded Protein/th> /tr> tr classborder-bottom align-bottom text-center> td>T/td> td>T/td> td>APOE-ε2/td> td>APOE2/td> /tr> tr classborder-bottom align-bottom text-center> td>T/td> td>C/td> td>APOE-ε3/td> td>APOE3/td> /tr> tr classborder-bottom align-bottom text-center> td>C/td> td>C/td> td>APOE-ε4/td> td>APOE4/td> /tr> /table> /div> p>Research has suggested that having the APOE-ε4 form increases one’s risk of developing Alzheimer’s disease more than having only APOE-ε2 or APOE-ε3 form; those who inherit two copies of the APOE-ε4 form have an even higher risksup>a namereportInternalLinks href#report/#reference> 2 - 4/a>/sup>. In addition, those with the APOE-ε4 form are more likely to develop Alzheimer’s disease at a younger age than those with the APOE-ε2 or APOE-ε3 formssup>a namereportInternalLinks href#report/#reference> 5/a>/sup>./p> p>A meta-analysissup>a namereportInternalLinks href#report/#reference> 6/a>/sup> including 20 published articles describing the frequency of the APOE-ε4 form among people in the United States who had been diagnosed with Alzheimer’s found that 56 percent had one copy of the APOE-ε4 gene, and 11 percent had two copies of the APOE-ε4 gene (see figure below)./p> div classcontainer w-80 stylemin-width: 666px> br> canvas idapoe_percentage_canvas>/canvas> br> /div> br> h3>Q: small>b>What is APOE status?/b>/small> /h3> p>Each person inherits one copy of the APOE gene in a certain form from each parent. The combination of the 2 copies of the APOE forms represents the APOE status (See table below)./p> div classcontainer w-80> p>span classfont-weight-bold>Table: /span>Estimated Percentages of the U.S. Population by APOE statussup>a namereportInternalLinks href#report/#reference> 7/a>/sup> (Source: a hrefmedia/HomeOffice/Facts%20and%20Figures/facts-and-figures.pdf target_new>Alzheimer’s Association/a>)/p> table classtable-sm table-striped table-hover w-75 aligncenter> tr classborder-bottom border-top text-center font-weight-bold> th>APOE Status/th> th>Percentagesup>*/sup>/th> /tr> tr classborder-bottom align-bottom text-center> td>APOE-ε2 / APOE-ε2/td> td>0.5/td> /tr> tr classborder-bottom align-bottom text-center> td>APOE-ε2 / APOE-ε3/td> td>11/td> /tr> tr classborder-bottom align-bottom text-center> td>APOE-ε2 / APOE-ε4/td> td>2/td> /tr> tr classborder-bottom align-bottom text-center> td>APOE-ε3 / APOE-ε3/td> td>61/td> /tr> tr classborder-bottom align-bottom text-center> td>APOE-ε3 / APOE-ε4/td> td>23/td> /tr> tr classborder-bottom align-bottom text-center> td>APOE-ε4 / APOE-ε4/td> td>2/td> /tr> /table> p>sup>*/sup>small>Percentages do not total 100 due to rounding./small>/p> /div> /div> div classcontainer pt-3 pb-3 text-justify nameancestryImputeTag> h3>Q: small>b>What does “imputed” mean? Why do the genotypes of APOE loci in my genome need to be imputed?/b>/small> /h3> p>Imputation in genetics refers to using a statistical approach to infer the genotypes of missing loci with known genotypes of other loci in the genome that are generally inherited together./p> p>When you see that APOE genotypes are imputed in your report, it means the original raw data file either does not have this genotype information or the genotypes provided are believed to contain errors based on researchers’ analyses. In those cases, other loci in your genome are used to infer (impute) the genotypes of the APOE loci, rs429358 and rs7412./p> p>It is a known issue for Ancestry.com users that the raw data file often fails to include or may misreport the genotypes for APOE status (see a hrefhttps://www.snpedia.com/index.php/APOE target_new>here/a>). Thus, to identify the APOE status, the genotypes of rs429358 and rs7412 are imputed based on genotypes of other loci in your genome. Although genotypes with high correlations with this particular APOE status are used, imputation may not always be accurate and accordingly, your actual APOE status may differ from what is presented here. Dash Genomics has not independently verified any of the genotypes reported by Ancestry that are used for the imputation process./p> /div> div> h4 classsmall font-weight-bold idreference>Reference /h4> ol classsmall> li idrefindex38>Mahley RW, Rall Jr. SC. Apolipoprotein E: Far more than a lipid transport protein. Annu Rev Genomics Hum Genet 2000;1:507-37./li> li idrefindex37>Loy CT, Schofield PR, Turner AM, Kwok JBJ. Genetics of dementia. Lancet 2014;383:828-40. /li>li idrefindex40>Holtzman DM, Herz J, Bu G. Apolipoprotein E and apolipoprotein E receptors: Normal biology and roles in Alzheimer disease. Cold Spring Harb Perspect Med 2012;2(3):a006312./li> li idrefindex41>Alzheimer’s Drug Discovery Foundation. What APOE Means for Your Health. Available at: http://www.alzdiscovery.org/cognitive-vitality/what-apoe-means-for-your-health. Accessed September 27, 2017./li> li idrefindex43>Ward A, Crean S, Mercaldi CJ, Collins JM, Boyd D, Cook MN, et al. Prevalence of apolipoprotein e4 genotype and homozygotes (APOE e4/4) among patients diagnosed with Alzheimer’s disease: A systematic review and meta-analysis. Neuroepidemiology 2012;38:1-17./li> li idrefindex42>Spinney L. Alzheimer’s disease: The forgetting gene. Nature 2014;510(7503):26-8./li> li idrefindex39>Raber J, Huang Y, Ashford JW. APOE genotype accounts for the vast majority of AD risk and AD pathology. Neurobiol Aging 2004;25:641-50./li> /ol> /div> /div> div classcontainer pt-5> h4>Your APOE status report:/h4> br> table classtable-sm table-striped table-hover w-80 aligncenter> tr> th classw-100 border-bottom border-top colspan4>APOE Genotype/th> /tr> tr classborder-bottom align-bottom> td classw-50 text-right>rs429358 span classd-none idrs429358-imputed>(imputed)/span>sup> */sup>: /td> td classw-50 text-center namers429358-imputed-genotype>b>CC/b>/td> /tr> tr classborder-bottom align-bottom> td classw-50 text-right>rs7412 span classd-none idrs7412-imputed>(imputed)/span>sup> */sup>: /td> td classw-50 text-center namers7412-imputed-genotype>b>CC/b>/td> /tr> /table> br> table classtable-sm table-striped table-hover w-80 aligncenter> tr> th classw-100 border-bottom border-top colspan4>APOE Status/th> /tr> tr classborder-bottom align-bottom> td classw-50 text-right>APOE-ε4 Copy Count sup>**/sup>: /td> td classw-50 text-center nameapoe-variant-count>b>0/b>/td> /tr> tr classborder-bottom align-bottom> td classw-50 text-right>APOE Status: /td> td classw-50 text-center nameapoe-status>b>APOE-ε4 / APOE-ε4/b>/td> /tr> /table> /div> !-- p classtext-justify> Using the proprietary research model and your genetic data file from a namedataSource>/a>, we have provided information below on: /p> --> div classcontainer w-80 mt-4 mb-4> p name23andMeTag>sup>*/sup> small>APOE status is determined based on your raw data file provided by 23andMe. We have not independently verified any of the information provided by 23andMe./small>/p> p nameancestryImputeTag>sup>*/sup> small>We have imputed genotypes of rs429358 and/or rs7412, because of a known issue for Ancestry.com users where the raw data file may fail to include or may misreport certain genotypes for APOE loci. We report your APOE status above based on the imputed genotypes. For reference, your actual Ancestry.com raw data file reported the following genotypes: rs429358 (span namers429358-genotype>/span>) and rs7412 (span namers7412-genotype>/span>)./small>/p> p>sup>**/sup> small>Number of copies of the APOE-ε4 form of the APOE gene in your genome./small>/p>p> /p>/div> /div> /div> div classcontainer idNextStep> div data-animatefadeIn data-animate-duration0.8 styleanimation-duration: 0.8s; classanimated animated-done> hr classhr-lg mt-7 mb-8 w-10 mx-auto hr-primary> h3 classtext-left text-uppercase font-weight-bold mt-0> Next Steps /h3> hr classmb-4 w-50 to-left> p classtext-justify> Remember, this analysis has not been validated for clinical or medical use and although this model looks at the similarity of your genetic information to the research cohort, none of the information presented here should be viewed as definitive regarding your Alzheimer’s disease risk or whether you will or will not get Alzheimer’s disease. Always consult with a medical professional before taking any actions related to your health. /p> p classtext-justify> You can learn more about Alzheimer’s disease through the following resources: /p> p>/p> ul classlist mb-3> li classlist-item>a idalzLink target_new hrefhttps://www.alz.org/>Alzheimers Association/a>/li> li classlist-item>a idmayoLink target_new hrefhttps://www.mayoclinic.org/diseases-conditions/alzheimers-disease/symptoms-causes/syc-20350447>Mayo Clinics/a>/li> /ul> p classtext-justify> Have questions on the genetic information related to this research? You can find and contact a genetic counselor by visiting the a idnsgcLink target_new hrefhttps://www.nsgc.org/findageneticcounselor>National Society of Genetic Counselors/a>. /p> /div> /div> /div> /div> /div> /div> div classcreate-account page> form> div classcontainer> nav classbreadcrumb> h4> span classbreadcrumb-item active>Account/span> span classbreadcrumb-item>Payment/span> span classbreadcrumb-item>Review/span> /h4> /nav> div classmb-4 bg-light p-3 rounded mb-4 idcreateAccount> div classrow col-md-12> div classcol-md-7> h4 classmt-4>Create an Account/h4> div classrow mt-4 pt-3> div classcol> span>Once you create an account, you can upload your data and get immediate access to your results./span> /div> /div> div classrow mt-4> div classcol mb-3> label classsr-only>First Name/label> input namefirstName typetext classform-control placeholderFirst Name required> div classinvalid-feedback> Required /div> /div> /div> div classrow> div classcol mb-3> label classsr-only>Last Name/label> input namelastName typetext classform-control placeholderLast Name required> div classinvalid-feedback> Required /div> /div> /div> div classrow> div classcol mb-3 form-group> label forformGroupExampleInput classcol-form-label>Date of Birth/label> select iddobmonth>/select> select iddobday>/select> select iddobyear>/select> div classinvalid-feedback dob> span classinvalid-feedback-dob>/span> /div> /div> /div> div classrow> div classcol mb-3> label classsr-only>Email/label> input nameemail typeemail classform-control placeholderEmail required> div classinvalid-feedback> Invalid email format /div> /div> /div> div classrow> div classcol mb-3> label classsr-only>Password/label> input namepassword typepassword classform-control placeholderPassword required minlength3> div classinvalid-feedback password> Password must be at least 3 characters /div> /div> /div> div classrow> div classform-group ml-3> div classform-check> input typecheckbox classform-check-input namehaveFile idhaveFile valuehaveFile required> div classcol mb-3> label classform-check-label forhaveFile> I have my genomic data file from a name23andmeLink>23andMe/a> or a nameancestryLink>Ancestry.com/a>sup>*/sup>. /label> /div> div classinvalid-feedback ml-3> You must acknowledge that you have one of these files before continuing /div> /div> /div> /div> div classrow> div classform-group ml-3> div classform-check> input typecheckbox classform-check-input nametosAgree idtosAgree valuetosAgree required> div classcol mb-3> label classform-check-label fortosAgree> I am at least 18 years old and agree to the a target_new href#tos>Terms of Service/a> and a target_new href#privacy>Privacy Policy/a>. I understand that this analysis is for informational purposes only and is not intended for clinical use and I have read and consent to all the a target_new href#product/#productLimitation>Limitations/a> and a target_new href#product/#productDisclaimer>Disclaimers/a>. /label> /div> div classinvalid-feedback ml-3> You must agree to the terms of service before continuing /div> /div> /div> /div> div classrow> div classform-group ml-3> p>* small>We support all 23andMe and Ancestry raw data files, but note that certain Ancestry files require us to impute (infer the values for) the genotypes of certain important genetic loci from other parts in your genome - which can affect accuracy./small>/p> /div> /div> /div> div classcol-md-5 nameorder-summary> /div> /div> /div> div classrow> div classcol-md-8>/div> div classcol-md-4> input idbutton-payment typesubmit classbtn btn-lg btn-primary float-right text-uppercase font-weight-bold btn-rounded-right px-4 valueContinue to payment> /div> /div> /div> /form> /div> div classpayment page> form idpayment-form> div classcontainer> nav classbreadcrumb> h4> span classbreadcrumb-item>Account/span> span classbreadcrumb-item active>Payment/span> span classbreadcrumb-item>Review/span> /h4> /nav> div classbg-light p-3 rounded mb-4 idpayment> div classrow col-md-12> div classcol-md-7 mt-4> h4>Payment Information/h4> div classrow mt-4 pt-3> div classcol mb-3> label classsr-only>Name on the card/label> input nameccName typetext classform-control placeholderName on the card required> div classinvalid-feedback> Required /div> /div> /div> div classrow> div classcol mb-3> !-- form idpayment-form> --> div idcard-element classform-control> !-- A Stripe Element will be inserted here. --> /div> !-- Used to display form errors. --> div idcard-errors stylecolor: #dc3545; font-size: 80%; margin-top: .25rem>/div> !-- /form> --> /div> /div> /div> div classcol-md-5 nameorder-summary> !-- order summary table will be insert here --> /div> /div> /div> div classrow align-middle> div classcol> a href#create-account classbtn btn-lg border-0>Back to Account/a> /div> div classcol> input idbutton-review typesubmit classbtn btn-lg btn-primary float-right text-uppercase font-weight-bold btn-rounded-right px-4 valueContinue to Review> /div> /div> /div> /form> /div> !-- review page --> div classreview page> div classcontainer> nav classbreadcrumb> h4> span classbreadcrumb-item>Account/span> span classbreadcrumb-item>Payment/span> span classbreadcrumb-item active>Review/span> /h4> /nav> div idalert-account-exists classalert alert-danger rolealert styledisplay:none> Account already exists. Please log in instead. /div> div idalert-payment-error classalert alert-danger rolealert styledisplay:none> Your payment could not be processed. Please double check that all your information is accurate. /div> div classmb-4 bg-light p-3 rounded mb-4 idreview> !-- div classrow> div classcol-md-8>/div> div classcol-md-4>h4>Order Summary/h4>/div> /div> --> form idform-order> div classrow col-md-12> div classcol-md-7> h4 classmt-4>Review Order/h4> div classrow mt-4 pt-3> div classcol-md-9>h5>Account Information/h5>/div> div classcol-md-3>a href#create-account>Edit/a>/div> /div> div classrow> div classcol-md-3>Name:/div> div idname classcol-md-4>/div> input typehidden namefirstName> input typehidden namelastName> /div> div classrow> div classcol-md-3>Date of Birth:/div> div iddob classcol-md-4>/div> input typehidden namedob> /div> div classrow> div classcol-md-3>Email:/div> div idemail classcol-md-4>/div> input typehidden nameemail> /div> div classrow> div classcol-md-3>Password:/div> div classcol-md-4>******/div> input typehidden namepassword> /div> !-- Consent related values--> input typecheckbox namehaveFile classd-none> input typecheckbox nametosAgree classd-none> div classrow pt-3> div classcol-md-9>h5>Payment Information/h5>/div> div classcol-md-3>a href#payment>Edit/a>/div> /div> div classrow> div classcol-md-3>Name on Card:/div> div idccName classcol-md-4>/div> input typehidden nameccName> /div> div classrow> div classcol-md-3>Credit Card:/div> div idccLast4 classcol-md-4>/div> input typehidden namestripeToken> /div> div classrow> div classcol-md-3>Expiration Date:/div> div idexpDate classcol-md-4>/div> /div> div classrow mb-3> div classcol-md-3>Zip Code:/div> div idzipCode classcol-md-4>/div> input typehidden namezipCode> /div> /div> div classcol-md-5 nameorder-summary> /div> /div> /form> /div> !-- End of gray bg--> div classrow> div classcol> a href#payment classbtn btn-lg border-0>Back to Payment/a> /div> div classcol> input idbutton-order typebutton classbtn btn-lg btn-primary float-right text-uppercase font-weight-bold btn-rounded-right px-4 valueSubmit Order> /div> /div> /div> /div> div classthankyou page> div classcontainer content-spacer-top> nav classbreadcrumb> h4> span classbreadcrumb-item>Account/span> span classbreadcrumb-item>Payment/span> span classbreadcrumb-item>Review/span> span classbreadcrumb-item active>i classfas fa-check icon-1.5x text-primary>/i> Completed/span> /h4> /nav> div classmb-4 bg-light p-3 rounded mb-4 idreview> div classrow col-md-12> div classcol-md-7> div classrow align-center> div idthankyou classcontainer> form idform-thankyou classform-thankyou> h4 classmt-4> i classfas fa-check icon-1.5x text-primary>/i>span> Order Completed/span> /h4> div classrow mt-4 mb-4 pt-3> div classcol-md-9>h5>Thank you for your order!/h5>/div> /div> ul> li>Access your results immediately by a href#upload>uploading/a> your compatible data file. /li> p> /p>li>You will receive a confirmation email shortly. 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