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body classpath-frontpage page-node-type-home page-enter>    a href#main-content classvisually-hidden focusable skip-link>      Skip to main content    /a>    div idpageCanvas>      noscript>iframe srchttps://www.googletagmanager.com/ns.html?idGTM-MBPNGL8                  height0 width0 styledisplay:none;visibility:hidden>/iframe>/noscript>        div classdialog-off-canvas-main-canvas data-off-canvas-main-canvas>              div idmySidenav classsidenav>          /div>    button typebutton classnavbar-toggle >      span classsr-only>Toggle navigation/span>      span classicon-bar>/span>      span classicon-bar>/span>      span classicon-bar>/span>    /button>    div idlayout-container>      header idnavbar rolebanner >                        div classcontainer>                div classnavbar-header js-navbar-header>          div classcontainer>            div classrow>              div classnavbar-header__wrapper>                  div classregion region-navigation>    div idblock-cslb-branding classblock block-system block-system-branding-block>              a href/ relhome classsite-logo>      img src/sites/default/files/Portraits_of_Progress_black_logo.svg altPortraits of Progress - Decades of Progress in Hemophilia />    /a>      /div>nav rolenavigation aria-labelledbyblock-cslb-main-menu-menu idblock-cslb-main-menu classblock block-menu navigation menu--main>              h2 classvisually-hidden idblock-cslb-main-menu-menu>Main navigation/h2>                        ul classmenu>                    li classmenu-item>        a href/ data-drupal-link-system-path<front> classis-active>Portrait of Progress/a>              /li>                li classmenu-item>        a href/learn-more-about-gene-therapy-and-hemophilia data-drupal-link-system-pathnode/17>About Haemophilia/a>              /li>                li classmenu-item>        a href/rankin-and-the-exhibit data-drupal-link-system-pathnode/16>Rankin and the Portraits/a>              /li>        /ul>    /nav>  /div>                                button classmenu-toggle js-menu-toggle aria-controlsmain-nav aria-labelBurger menu button aria-expandedfalse namemenu button>                  span classicon-bar>/span>                  span classicon-bar>/span>                  span classicon-bar>/span>                /button>              /div>            /div>          /div>        /div>        div classnavbar-header__mobile>            div classregion region-navigation-mobile>    div idblock-sitebranding classblock block-system block-system-branding-block>              a href/ relhome classsite-logo>      img src/sites/default/files/Portraits_of_Progress_black_logo.svg altHome />    /a>      /div>nav rolenavigation aria-labelledbyblock-mainnavigation-menu idblock-mainnavigation classblock block-menu navigation menu--main>              h2 classvisually-hidden idblock-mainnavigation-menu>Main navigation/h2>                        ul classmenu>                    li classmenu-item>        a href/ data-drupal-link-system-path<front> classis-active>Portrait of Progress/a>              /li>                li classmenu-item>        a href/learn-more-about-gene-therapy-and-hemophilia data-drupal-link-system-pathnode/17>About Haemophilia/a>              /li>                li classmenu-item>        a href/rankin-and-the-exhibit data-drupal-link-system-pathnode/16>Rankin and the Portraits/a>              /li>        /ul>    /nav>  /div>        /div>                  /div>        		div classdisclaimer-text>p>Disclaimer: due to compliance regulations, the content of this webpage is not intended for UK audiences/p>/div>      /header>                        div classhighlighted>  div classregion region-highlighted>    div data-drupal-messages-fallback classhidden>/div>div classviews-element-container block block-views block-views-blockheader-hero-block-1 idblock-views-block-header-hero-block-1>                            div classviews-field views-field-nothing>span classfield-content>div classhero-banner roleheading>  img classhero-banner__letter -line-1 -left src/themes/custom/cslb/img/hero-banner/letters/line-1-left.svg altPortraits Of Progress>  img classhero-banner__letter -line-1 -right src/themes/custom/cslb/img/hero-banner/letters/line-1-right.svg altPortraits Of Progress>  img classhero-banner__letter -line-2 -right src/themes/custom/cslb/img/hero-banner/letters/line-2.svg altPortraits Of Progress>  img classhero-banner__letter -line-3 -left src/themes/custom/cslb/img/hero-banner/letters/line-3-left.svg altPortraits Of Progress>  img classhero-banner__letter -line-3 -right src/themes/custom/cslb/img/hero-banner/letters/line-3-right.svg altPortraits Of Progress>  div classhero-banner__content js-animated-block>    div classcontent js-content>      h1>/h1>      div classcontent__intro>p>span>span>span>span>span>span>From the identification of haemophilia A and B in the 1940s,sup>1/sup>/span>/span>/span>/span>/span>/span>span>span>span>span>span>span> the past 70 years have revolutionised our understanding and treatment of the disease./span>/span>/span>/span>/span>/span>/p>p>span>span>span>span>span>span>As we look to the future, learn how haemophilia and the evolving treatment landscape has impacted the lives of this community. /span>/span>/span>/span>/span>/span>/p>p>span>span>span>span>span>span>This is Portraits of Progress – join us as we celebrate how far we’ve come./span>/span>/span>/span>/span>/span>/p>/div>      span classcontent__text>Enter Gallery/span>      img classcontent__arrow js-content__arrow src/themes/custom/cslb/img/icons/enter-gallery-arrow.svg altPortraits Of Progress>    /div>  /div>  div classhero-banner__img>    img src/themes/custom/cslb/img/hero-banner/portraits-of-progress.svg altPortraits Of Progress>  /div>/div>/span>/div>              /div>  /div>/div>              div rolemain classmain-container container js-quickedit-main-content>      div classrow>                                                        section classcol-sm-12>                                                                        a idmain-content>/a>            div classctn-main>                div classregion region-content>    div idblock-cslb-content classblock block-system block-system-main-block>            article data-history-node-id1 about/node/1 classnode node--type-home node--promoted node--view-mode-full>          div classnode__content>      /div>/article>  /div>div classviews-element-container block block-views block-views-blocktimeline-layout-block-1 idblock-views-block-timeline-layout-block-1>                            div id1940s–1960s classtimeline js-timeline>  div classtimeline__wrapper ctn-main>    div classtimeline__section-year>                      div classsection-year__row js-default-items -left-right>                  div classsection-year js-section-year js-animated-block   -no-title>    div classsection-year__content>          span classyear>1947/span>                  p>span>Dr Alfredo Pavlovsky, a doctor in Buenos Aires, Argentina, distinguishes two types of haemophilia in his lab – A and B.sup>1/sup>/span>/p>          /div>/div>  div classsection-year js-section-year js-animated-block -has-img  -no-title>      div classsection-year__img -desktop-only>        img loadinglazy src/sites/default/files/timeline/1940s-60s.jpg width1040 height1338 altCSL Behring typeofImage />              span classimg__caption>Image courtesy of CSL Behring/span>          /div>    div classsection-year__content>          span classyear>1952/span>                  p>span>Stephen Christmas is diagnosed with haemophilia B, which doctors colloquially refer to as Christmas Disease. Fresh frozen plasma is the only treatment option available, and the average life expectancy is less than 20 years old.sup>1/sup>/span>/p>              div classcontent__mobile>        div classcontent__img>            img loadinglazy src/sites/default/files/timeline/1940s-60s.jpg width1040 height1338 altCSL Behring typeofImage />                      span classimg__caption>Image courtesy of CSL Behring/span>                  /div>        div classcontent__text>                              p>span>Stephen Christmas is diagnosed with haemophilia B, which doctors colloquially refer to as Christmas Disease. Fresh frozen plasma is the only treatment option available, and the average life expectancy is less than 20 years old.sup>1/sup>/span>/p>                  /div>      /div>      /div>/div>            /div>  div classsection-year__row js-default-items ->                              /div>div data-iddan classsection-year__row -is-story - >  div classsection-year js-animated-block -no-video>    div classsection-year__story js-section-year__story>      div classstory__header -before>        div classspacer>/div>        div classheader js-story-content >                      span classsection-year__cat>Patient/span>                                h2>Dan/h2>                  /div>      /div>      div classstory__img-video -before>                          div classsection-year__img js-story-content>              img loadinglazy src/sites/default/files/timeline/dan.jpg width1920 height2487 altRankin portrait of hemophilia patient, Dan typeofImage />          /div>               /div>              div classstory__content -before>          div classspacer>/div>          div classsection-year__content js-story-content>            p>span>span>span>span>span>span>Dan has experienced the full treatment spectrum for haemophilia, from lyophilised plasma to factor. Now with a young grandson who also has haemophilia, he’s amazed by how far we’ve come and is excited for where the science is headed./span>/span>/span>/span>/span>/span>/p>                              a href/story/dan>Dan's story/a>                        /div>        /div>                /div>  /div>/div>                /div>  /div>/div>  div id1970s classtimeline js-timeline>  div classtimeline__wrapper ctn-main>    div classtimeline__section-year>                      div classsection-year__row js-default-items -right>                  div classsection-year js-section-year js-animated-block -has-img  -no-title>      div classsection-year__img -desktop-only>        img loadinglazy src/sites/default/files/timeline/1970s.jpg width1508 height1158 altGary Bottoms typeofImage />              span classimg__caption>Image courtesy of Gary Bottoms/span>          /div>    div classsection-year__content>          span classyear>1970s/span>                  p>Factor concentrates in powdered form become available, allowing for home infusions and a significant reduction in treatment time.sup>1/sup> /p>hr />p>Researchers pioneer genetic engineering, creating the potential to treat genetic conditions by modifying a person’s genes.sup>2/sup>/p>              div classcontent__mobile>        div classcontent__img>            img loadinglazy src/sites/default/files/timeline/1970s.jpg width1508 height1158 altGary Bottoms typeofImage />                      span classimg__caption>Image courtesy of Gary Bottoms/span>                  /div>        div classcontent__text>                              p>Factor concentrates in powdered form become available, allowing for home infusions and a significant reduction in treatment time.sup>1/sup> /p>hr />p>Researchers pioneer genetic engineering, creating the potential to treat genetic conditions by modifying a person’s genes.sup>2/sup>/p>                  /div>      /div>      /div>/div>            /div>  div classsection-year__row js-default-items ->                              /div>div data-idsue classsection-year__row -is-story - >  div classsection-year js-animated-block -no-video>    div classsection-year__story js-section-year__story>      div classstory__header -before>        div classspacer>/div>        div classheader js-story-content >                      span classsection-year__cat>Healthcare Provider/span>                                h2>Sue/h2>                  /div>      /div>      div classstory__img-video -before>                          div classsection-year__img js-story-content>              img loadinglazy src/sites/default/files/timeline/sue.jpg width1920 height2474 altRankin portrait of hemophilia nurse coordinator, Sue typeofImage />          /div>               /div>              div classstory__content -before>          div classspacer>/div>          div classsection-year__content js-story-content>            p>span>span>span>span>span>span>Sue, a now-retired nurse coordinator, spent the last three decades on the front lines caring for people with haemophilia./span>/span>/span>/span>/span>/span>/p>                              a href/story/sue>Sue's story/a>                        /div>        /div>                /div>  /div>/div>                /div>  /div>/div>  div id1980s classtimeline js-timeline>  div classtimeline__wrapper ctn-main>    div classtimeline__section-year>                      div classsection-year__row js-default-items -right>                  div classsection-year js-section-year js-animated-block -has-img  -no-title>      div classsection-year__img -desktop-only>        img loadinglazy src/sites/default/files/timeline/1980s---Sue.jpg width902 height1181 altSue Geraghty typeofImage />              span classimg__caption>Image courtesy of Sue Geraghty/span>          /div>    div classsection-year__content>          span classyear>1980s/span>                  p>Scientists successfully clone the Factor VIII and IX genes, paving the way for breakthrough synthetic therapies (not derived from human plasma) using recombinant technologies.sup>1/sup>/p>hr />p> /p>              div classcontent__mobile>        div classcontent__img>            img loadinglazy src/sites/default/files/timeline/1980s---Sue.jpg width902 height1181 altSue Geraghty typeofImage />                      span classimg__caption>Image courtesy of Sue Geraghty/span>                  /div>        div classcontent__text>                              p>Scientists successfully clone the Factor VIII and IX genes, paving the way for breakthrough synthetic therapies (not derived from human plasma) using recombinant technologies.sup>1/sup>/p>hr />p> /p>                  /div>      /div>      /div>/div>            /div>                /div>  /div>/div>  div id1990s classtimeline js-timeline>  div classtimeline__wrapper ctn-main>    div classtimeline__section-year>                      div classsection-year__row js-default-items -right>                  div classsection-year js-section-year js-animated-block -has-img  -no-title>      div classsection-year__img -desktop-only>        img loadinglazy src/sites/default/files/2022-05/Thomas-Wilkes%5B54%5D.jpg width646 height414 altThomas Wilkes typeofImage />              span classimg__caption>Image courtesy of Thomas Wilkes/span>          /div>    div classsection-year__content>          span classyear>1990s/span>                  p>The first recombinant FIX products are approved by the US Food and Drug Administration (FDA) and European Medicines Agency (EMA) to treat haemophilia B, leading the way for prophylactic treatment, which dramatically improves patients’ lives.sup>1,3/sup>/p>hr />p>Haemophilia patient life expectancy improves to 67 years old.sup>4/sup>/p>              div classcontent__mobile>        div classcontent__img>            img loadinglazy src/sites/default/files/2022-05/Thomas-Wilkes%5B54%5D.jpg width646 height414 altThomas Wilkes typeofImage />                      span classimg__caption>Image courtesy of Thomas Wilkes/span>                  /div>        div classcontent__text>                              p>The first recombinant FIX products are approved by the US Food and Drug Administration (FDA) and European Medicines Agency (EMA) to treat haemophilia B, leading the way for prophylactic treatment, which dramatically improves patients’ lives.sup>1,3/sup>/p>hr />p>Haemophilia patient life expectancy improves to 67 years old.sup>4/sup>/p>                  /div>      /div>      /div>/div>            /div>  div classsection-year__row js-default-items -right>                              /div>div data-idadam classsection-year__row -is-story -right >  div classsection-year js-animated-block >    div classsection-year__story js-section-year__story>      div classstory__header -after>        div classspacer>/div>        div classheader js-story-content >                      span classsection-year__cat>Patient/span>                                h2>Adam/h2>                  /div>      /div>      div classstory__img-video -after>                  div classsection-year__video -desktop-only>            div classvideo__thumbnail js-video__thumbnail js-video -player-icon data-video-id6312921514112>                img loadinglazy src/sites/default/files/styles/story_video_thumbnail_500x281/public/timeline/Adam.jpg?itokV8xZZ1IP width500 height281 altWatch video of Adam’s story. typeofImage classimage-style-story-video-thumbnail-500x281 />            /div>          /div>                          div classsection-year__img js-story-content>              img loadinglazy src/sites/default/files/timeline/adam.jpg width1920 height2473 altRankin portrait of hemophilia patient, Adam typeofImage />          /div>               /div>              div classstory__content -after>          div classspacer>/div>          div classsection-year__content js-story-content>            p>span>span>span>span>span>span>A child of the 90s, Adam felt comfortable engaging in most activities with family and friends thanks to the availability of prophylactic haemophilia treatments./span>/span>/span>/span>/span>/span>/p>                              a href/story/adam>Adam's Story/a>                        /div>        /div>                    div classsection-year__video -mobile-only>          div classvideo__thumbnail js-video__thumbnail js-video -player-icon data-video-id6312921514112>              img loadinglazy src/sites/default/files/styles/story_video_thumbnail_500x281/public/timeline/Adam.jpg?itokV8xZZ1IP width500 height281 altWatch video of Adam’s story. typeofImage classimage-style-story-video-thumbnail-500x281 />          /div>        /div>          /div>  /div>/div>  div classsection-year__row js-default-items -left>                              /div>div data-iddr-klamroth classsection-year__row -is-story -left -main>  div classsection-year js-animated-block >    div classsection-year__story js-section-year__story>      div classstory__header -before>        div classspacer>/div>        div classheader js-story-content >                      span classsection-year__cat>Healthcare Provider/span>                                h2>Dr. Klamroth/h2>                  /div>      /div>      div classstory__img-video -before>                  div classsection-year__video -desktop-only>            div classvideo__thumbnail js-video__thumbnail js-video -player-icon data-video-id6312923999112>                img loadinglazy src/sites/default/files/timeline/Dr-Klamroth.jpg width3744 height2106 altWatch video of Dr. Klamroth’s story. typeofImage />            /div>          /div>                          div classsection-year__img js-story-content>              img loadinglazy src/sites/default/files/timeline/Dr-Klamroth.jpg width3744 height2106 altWatch video of Dr. Klamroth’s story. typeofImage />          /div>               /div>              div classstory__content -before>          div classspacer>/div>          div classsection-year__content js-story-content>            p>span>span>span>span>span>span>A leader in the haemophilia medical community, Dr. Klamroth has witnessed several major treatment advancements over the past 25 years and looks forward to what the next 25 years will bring./span>/span>/span>/span>/span>/span>/p>                              a href/story/dr-klamroth>Dr. Klamroth’s Story/a>                        /div>        /div>                    div classsection-year__video -mobile-only>          div classvideo__thumbnail js-video__thumbnail js-video -player-icon data-video-id6312923999112>              img loadinglazy src/sites/default/files/timeline/Dr-Klamroth.jpg width3744 height2106 altWatch video of Dr. Klamroth’s story. typeofImage />          /div>        /div>          /div>  /div>/div>                /div>  /div>/div>  div id2000s classtimeline js-timeline>  div classtimeline__wrapper ctn-main>    div classtimeline__section-year>                      div classsection-year__row js-default-items -right>                  div classsection-year js-section-year js-animated-block -has-img  -no-title>      div classsection-year__img -desktop-only>        img loadinglazy src/sites/default/files/2022-05/GettyImages-168166202_bw_4x.jpg width1280 height855 altEvidence grows for the potential typeofImage />          /div>    div classsection-year__content>          span classyear>2000s/span>                  p>span>Evidence grows for the potential of adeno-associated virus (AAV) vectors to deliver safe, effective, and lasting genes that produce blood-clotting factor in the body.sup>1/sup>/span>/p>              div classcontent__mobile>        div classcontent__img>            img loadinglazy src/sites/default/files/2022-05/GettyImages-168166202_bw_4x.jpg width1280 height855 altEvidence grows for the potential typeofImage />                  /div>        div classcontent__text>                              p>span>Evidence grows for the potential of adeno-associated virus (AAV) vectors to deliver safe, effective, and lasting genes that produce blood-clotting factor in the body.sup>1/sup>/span>/p>                  /div>      /div>      /div>/div>            /div>  div classsection-year__row js-default-items ->                              /div>div data-idjeron classsection-year__row -is-story - >  div classsection-year js-animated-block -no-video>    div classsection-year__story js-section-year__story>      div classstory__header -before>        div classspacer>/div>        div classheader js-story-content >                      span classsection-year__cat>Patient/span>                                h2>Jeron/h2>                  /div>      /div>      div classstory__img-video -before>                          div classsection-year__img js-story-content>              img loadinglazy src/sites/default/files/timeline/jeron.jpg width1920 height2472 altRankin portrait of hemophilia patient, Jeron typeofImage />          /div>               /div>              div classstory__content -before>          div classspacer>/div>          div classsection-year__content js-story-content>            p>span>span>span>span>span>span>Though held back from playing sports as a child, Jeron has channel/span>/span>/span>/span>/span>/span>span>span>span>span>span>span>span>l/span>/span>/span>/span>/span>/span>/span>span>span>span>span>span>span>ed his energy into being an advocate in the haemophilia community, travel/span>/span>/span>/span>/span>/span>span>span>span>span>span>span>span>l/span>/span>/span>/span>/span>/span>/span>span>span>span>span>span>span>ing the world and inspiring others with the condition./span>/span>/span>/span>/span>/span>/p>                              a href/story/jeron>Jeron's Story/a>                        /div>        /div>                /div>  /div>/div>                /div>  /div>/div>  div id2010s classtimeline js-timeline>  div classtimeline__wrapper ctn-main>    div classtimeline__section-year>                      div classsection-year__row js-default-items -right>                  div classsection-year js-section-year js-animated-block -has-img  -no-title>      div classsection-year__img -desktop-only>        img loadinglazy src/sites/default/files/timeline/Jennifer%202.jpg width1530 height1146 altJennifer Mermilliod typeofImage />              span classimg__caption>Image courtesy of Jennifer Mermilliod/span>          /div>    div classsection-year__content>          span classyear>2010s/span>                  p>Long-acting recombinant factor therapies are available offering the haemophilia community additional treatment options.sup>1/sup>/p>hr />p>Late-stage trials for AAV-based gene therapy in haemophilia begin.sup>6/sup>/p>              div classcontent__mobile>        div classcontent__img>            img loadinglazy src/sites/default/files/timeline/Jennifer%202.jpg width1530 height1146 altJennifer Mermilliod typeofImage />                      span classimg__caption>Image courtesy of Jennifer Mermilliod/span>                  /div>        div classcontent__text>                              p>Long-acting recombinant factor therapies are available offering the haemophilia community additional treatment options.sup>1/sup>/p>hr />p>Late-stage trials for AAV-based gene therapy in haemophilia begin.sup>6/sup>/p>                  /div>      /div>      /div>/div>            /div>  div classsection-year__row js-default-items -left>                              /div>div data-idstormy classsection-year__row -is-story -left >  div classsection-year js-animated-block >    div classsection-year__story js-section-year__story>      div classstory__header -after>        div classspacer>/div>        div classheader js-story-content >                      span classsection-year__cat>Patient/Caregiver/span>                                h2>Stormy/h2>                  /div>      /div>      div classstory__img-video -after>                  div classsection-year__video -desktop-only>            div classvideo__thumbnail js-video__thumbnail js-video -player-icon data-video-id6312922030112>                img loadinglazy src/sites/default/files/styles/story_video_thumbnail_500x281/public/timeline/Stormy.jpg?itokn2uVeFOk width500 height281 altWatch video of Stormy’s story. typeofImage classimage-style-story-video-thumbnail-500x281 />            /div>          /div>                          div classsection-year__img js-story-content>              img loadinglazy src/sites/default/files/timeline/stormy.jpg width1920 height2474 altRankin portrait of hemophilia patient and caregiver, Stormy typeofImage />          /div>               /div>              div classstory__content -after>          div classspacer>/div>          div classsection-year__content js-story-content>            p>span>span>span>span>span>span>As a woman with haemophilia and a caregiver to a son with haemophilia, Stormy has made it her mission to educate others, advocating for men and women alike in the haemophilia community./span>/span>/span>/span>/span>/span>/p>p> /p>                              a href/story/stormy>Stormy's story/a>                        /div>        /div>                    div classsection-year__video -mobile-only>          div classvideo__thumbnail js-video__thumbnail js-video -player-icon data-video-id6312922030112>              img loadinglazy src/sites/default/files/styles/story_video_thumbnail_500x281/public/timeline/Stormy.jpg?itokn2uVeFOk width500 height281 altWatch video of Stormy’s story. typeofImage classimage-style-story-video-thumbnail-500x281 />          /div>        /div>          /div>  /div>/div>                /div>  /div>/div>  div id2020s classtimeline js-timeline>  div classtimeline__wrapper ctn-main>    div classtimeline__section-year>                      div classsection-year__row js-default-items -right>                  div classsection-year js-section-year js-animated-block -has-img  -no-title>      div classsection-year__img -desktop-only>        img loadinglazy src/sites/default/files/timeline/2020s---Mike-Hargett.jpg width986 height1324 altMike Hargett typeofImage />              span classimg__caption>Image courtesy of Mike Hargett/span>          /div>    div classsection-year__content>          span classyear>2020s/span>                  p>Gene therapy trials in haemophilia continue to show promise in potentially decreasing annualised bleeding rates as well as the use of replacement therapy.sup>8/sup>/p>              div classcontent__mobile>        div classcontent__img>            img loadinglazy src/sites/default/files/timeline/2020s---Mike-Hargett.jpg width986 height1324 altMike Hargett typeofImage />                      span classimg__caption>Image courtesy of Mike Hargett/span>                  /div>        div classcontent__text>                              p>Gene therapy trials in haemophilia continue to show promise in potentially decreasing annualised bleeding rates as well as the use of replacement therapy.sup>8/sup>/p>                  /div>      /div>      /div>/div>            /div>  div classsection-year__row js-default-items -right>                              /div>div data-idwayne classsection-year__row -is-story -right >  div classsection-year js-animated-block >    div classsection-year__story js-section-year__story>      div classstory__header -after>        div classspacer>/div>        div classheader js-story-content >                      span classsection-year__cat>Patient/span>                                h2>Wayne/h2>                  /div>      /div>      div classstory__img-video -after>                  div classsection-year__video -desktop-only>            div classvideo__thumbnail js-video__thumbnail js-video -player-icon data-video-id6312920952112>                img loadinglazy src/sites/default/files/styles/story_video_thumbnail_500x281/public/timeline/Wayne.jpg?itokwwEx7her width500 height281 altWatch video of Wayne’s story. typeofImage classimage-style-story-video-thumbnail-500x281 />            /div>          /div>                          div classsection-year__img js-story-content>              img loadinglazy src/sites/default/files/timeline/wayne.jpg width1920 height2474 altRankin portrait of hemophilia patient, Wayne typeofImage />          /div>               /div>              div classstory__content -after>          div classspacer>/div>          div classsection-year__content js-story-content>            p>span>span>span>span>span>span>As an advocate for haemophilia for over 40 years, Wayne has experienced/span>/span>/span>/span>/span>/span>span>span>span>span>span>span>span>span> /span>/span>/span>/span>/span>/span>/span>/span>span>span>span>span>span>span>monumental advancements in haemophilia treatments and has committed his life to ensuring a better world for today’s haemophilia community./span>/span>/span>/span>/span>/span>/p>                              a href/story/wayne>Wayne's story/a>                        /div>        /div>                    div classsection-year__video -mobile-only>          div classvideo__thumbnail js-video__thumbnail js-video -player-icon data-video-id6312920952112>              img loadinglazy src/sites/default/files/styles/story_video_thumbnail_500x281/public/timeline/Wayne.jpg?itokwwEx7her width500 height281 altWatch video of Wayne’s story. typeofImage classimage-style-story-video-thumbnail-500x281 />          /div>        /div>          /div>  /div>/div>  div classsection-year__row js-default-items -right>                              /div>div data-idlukas classsection-year__row -is-story -right >  div classsection-year js-animated-block >    div classsection-year__story js-section-year__story>      div classstory__header -after>        div classspacer>/div>        div classheader js-story-content >                      span classsection-year__cat>Patient/span>                                h2>Lukas/h2>                  /div>      /div>      div classstory__img-video -after>                  div classsection-year__video -desktop-only>            div classvideo__thumbnail js-video__thumbnail js-video -player-icon data-video-id6312922246112>                img loadinglazy src/sites/default/files/styles/story_video_thumbnail_500x281/public/2022-09/Lukas%20image_0.png?itokG_w28RuD width500 height281 altLukas Image typeofImage classimage-style-story-video-thumbnail-500x281 />            /div>          /div>                          div classsection-year__img js-story-content>              img loadinglazy src/sites/default/files/2022-09/Lukas%20image.png width1166 height1072 altLukas Image typeofImage />          /div>               /div>              div classstory__content -after>          div classspacer>/div>          div classsection-year__content js-story-content>            p>Diagnosed at nine months old, Lukas hopes to shine a light on life with haemophilia, including the importance of increasing understanding of the disease to ensure children with haemophilia are given the same opportunities as their peers at school, as well as his hopes for the future. /p>                              a href/story/lukas>Lukas' story/a>                        /div>        /div>                    div classsection-year__video -mobile-only>          div classvideo__thumbnail js-video__thumbnail js-video -player-icon data-video-id6312922246112>              img loadinglazy src/sites/default/files/styles/story_video_thumbnail_500x281/public/2022-09/Lukas%20image_0.png?itokG_w28RuD width500 height281 altLukas Image typeofImage classimage-style-story-video-thumbnail-500x281 />          /div>        /div>          /div>  /div>/div>  div classsection-year__row js-default-items -right>                              /div>div data-idalex-and-josh classsection-year__row -is-story -right >  div classsection-year js-animated-block >    div classsection-year__story js-section-year__story>      div classstory__header -after>        div classspacer>/div>        div classheader js-story-content >                      span classsection-year__cat>Patient/span>                                h2>Alex and Josh/h2>                  /div>      /div>      div classstory__img-video -after>                  div classsection-year__video -desktop-only>            div classvideo__thumbnail js-video__thumbnail js-video -player-icon data-video-id6316464525112>                img loadinglazy src/sites/default/files/styles/story_video_thumbnail_500x281/public/2022-12/Alex-and-Josh_2.png?itoktui6QLCo width500 height281 altalex-and-josh typeofImage classimage-style-story-video-thumbnail-500x281 />            /div>          /div>                          div classsection-year__img js-story-content>              img loadinglazy src/sites/default/files/2022-12/Alex-and-Josh_1.png width967 height489 altalex-and-josh typeofImage />          /div>               /div>              div classstory__content -after>          div classspacer>/div>          div classsection-year__content js-story-content>            p>Alex and Josh, now 26, were born and raised in the UK. At three years old the brothers were diagnosed with severe haemophilia A. Growing up they found it difficult to fit in with their peers, especially as they were unable to take part in popular school sports such as rugby. Despite this, they got used to learning how to better manage their haemophilia and now strive to live as ‘normal’ a life as possible./p>p> /p>                              a href/node/36>Alex and Josh's story/a>                        /div>        /div>                    div classsection-year__video -mobile-only>          div classvideo__thumbnail js-video__thumbnail js-video -player-icon data-video-id6316464525112>              img loadinglazy src/sites/default/files/styles/story_video_thumbnail_500x281/public/2022-12/Alex-and-Josh_2.png?itoktui6QLCo width500 height281 altalex-and-josh typeofImage classimage-style-story-video-thumbnail-500x281 />          /div>        /div>          /div>  /div>/div>  div classsection-year__row js-default-items -right>                              /div>div data-idfabio classsection-year__row -is-story -right >  div classsection-year js-animated-block >    div classsection-year__story js-section-year__story>      div classstory__header -after>        div classspacer>/div>        div classheader js-story-content >                      span classsection-year__cat>Patient/span>                                h2>Fabio/h2>                  /div>      /div>      div classstory__img-video -after>                  div classsection-year__video -desktop-only>            div classvideo__thumbnail js-video__thumbnail js-video -player-icon data-video-id6318808566112>                img loadinglazy src/sites/default/files/styles/story_video_thumbnail_500x281/public/2023-01/Fabio_2.jpg?itokBPqXi1Y- width500 height281 altFabios image typeofImage classimage-style-story-video-thumbnail-500x281 />            /div>          /div>                          div classsection-year__img js-story-content>              img loadinglazy src/sites/default/files/2023-01/Fabio_1.jpg width898 height493 altFabios image typeofImage />          /div>               /div>              div classstory__content -after>          div classspacer>/div>          div classsection-year__content js-story-content>            p>Fabio is 27 years old and was diagnosed with severe haemophilia B when he was two. Despite the setbacks he has faced, Fabio does not allow haemophilia to hinder his passions. He actively participates in sports, cycling around his hometown of Zaragoza, Spain and camping in the mountains. Hopes for new treatment options keep Fabio optimistic for the future, with the prospect of a freer life, away from regular hospital visits./p>p> /p>                              a href/node/37>Fabios' story/a>                        /div>        /div>                    div classsection-year__video -mobile-only>          div classvideo__thumbnail js-video__thumbnail js-video -player-icon data-video-id6318808566112>              img loadinglazy src/sites/default/files/styles/story_video_thumbnail_500x281/public/2023-01/Fabio_2.jpg?itokBPqXi1Y- width500 height281 altFabios image typeofImage classimage-style-story-video-thumbnail-500x281 />          /div>        /div>          /div>  /div>/div>  div classsection-year__row js-default-items -right>                              /div>div data-ideke-and-sterre classsection-year__row -is-story -right >  div classsection-year js-animated-block >    div classsection-year__story js-section-year__story>      div classstory__header -after>        div classspacer>/div>        div classheader js-story-content >                      span classsection-year__cat>Patient/span>                                h2>Eke and Sterre/h2>                  /div>      /div>      div classstory__img-video -after>                  div classsection-year__video -desktop-only>            div classvideo__thumbnail js-video__thumbnail js-video -player-icon data-video-id6338526257112>                img loadinglazy src/sites/default/files/styles/story_video_thumbnail_500x281/public/2023-12/MicrosoftTeams-image%20%281%29%20%281%29_2.png?itokZlICqek4 width500 height281 altEke and Sterre typeofImage classimage-style-story-video-thumbnail-500x281 />            /div>          /div>                          div classsection-year__img js-story-content>              img loadinglazy src/sites/default/files/2023-12/MicrosoftTeams-image%20%281%29%20%281%29_1.png width1566 height792 altEke and Sterre typeofImage />          /div>               /div>              div classstory__content -after>          div classspacer>/div>          div classsection-year__content js-story-content>            p>Eke and Sterre, a mother and daughter with haemophilia, share their experiences, emphasising the advances made in the understanding and treatment of haemophilia in women and girls./p>                              a href/node/41>Eke and Sterre's story/a>                        /div>        /div>                    div classsection-year__video -mobile-only>          div classvideo__thumbnail js-video__thumbnail js-video -player-icon data-video-id6338526257112>              img loadinglazy src/sites/default/files/styles/story_video_thumbnail_500x281/public/2023-12/MicrosoftTeams-image%20%281%29%20%281%29_2.png?itokZlICqek4 width500 height281 altEke and Sterre typeofImage classimage-style-story-video-thumbnail-500x281 />          /div>        /div>          /div>  /div>/div>                /div>  /div>/div>              footer>      div classtimeline__years js-timeline__years>  span classyear__border js-year__border>/span>                  a classyear js-year href#1940s–1960s>1940s – 1960s/a>  a classyear js-year href#1970s>1970s/a>  a classyear js-year href#1980s>1980s/a>  a classyear js-year href#1990s>1990s/a>  a classyear js-year href#2000s>2000s/a>  a classyear js-year href#2010s>2010s/a>  a classyear js-year href#2020s>2020s/a>             /div>div classstory__video-modal js-story__video-modal>/div>    /footer>      /div>  /div>            /div>                  /section>                      /div>    /div>      footer classfooter rolecontentinfo>                  div classcontainer>            div classregion region-footer-wide>    div idblock-references classblock block-block-content block-block-contenta4223ad1-3ac4-4e73-b7a2-2ab6992df204>                        div classclearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item>p> /p>p> /p>p> /p>p>sup>1/sup> Mannucci P. Back to the future: a recent history of haemophilia treatment. Haemophilia 2008; 14(3) ; 10-18.br />sup>2/sup> Friedmann T. A brief history of gene therapy. i>Nature/i> 1992; 2:93-98.br />sup>3/sup>  EMA. i>Benefix: Authorisation details/i>. Available at: a hrefhttp://www.ema.europa.eu/en/medicines/human/EPAR/benefix#authorisation-details-section>www.ema.europa.eu/en/medicines/human/EPAR/benefix#authorisation-details-section/a> (Accessed September 2022).br />sup>4/sup> Czapek LA et al. Life expectancy in Haemophilia outcome. i>J Thromb Haemostat/i> 2006; 4(3):507-509.br />sup>5/sup> Srivastava et al. WFH Guidelines for the Management of Hemophilia, 3sup>rd/sup> Edition. i>Haemophilia/i> 2020. 6 (Suppl 6):1-158.br />sup>6/sup> ClinicalTrials.gov.i> HOPE-B: Trial of AMT-061 in Severe or Moderately Severe Haemophilia B Patients/i>. Available at: a hrefhttp://www.clinicaltrials.gov/ct2/show/NCT03569891>www.clinicaltrials.gov/ct2/show/NCT03569891/a> (Accessed September 2022).br />sup>7/sup> Myrin-Westesson L et al. The experience of being a female care of haemophilia. Haemophilia 2013; 19(2): 219-224.br />sup>8/sup> Pipe SW et al. First Data from the Phase 3 HOPE-B Gene Therapy Trial. i>Ash Publications/i> 2020; presentation./p>/div>        /div>nav rolenavigation aria-labelledbyblock-footermenu-menu idblock-footermenu classblock block-menu navigation menu--footer-menu>              h2 classvisually-hidden idblock-footermenu-menu>Footer Menu/h2>                  ul classmenu>                  li classmenu-item>        a href/ data-drupal-link-system-path<front> classis-active>Portraits of Progress/a>              /li>                li classmenu-item>        a href/learn-more-about-gene-therapy-and-hemophilia data-drupal-link-system-pathnode/17>About Haemophilia/a>              /li>                li classmenu-item>        a href/rankin-and-the-exhibit data-drupal-link-system-pathnode/16>Rankin and the Portraits/a>              /li>      /ul>      /nav>nav rolenavigation aria-labelledbyblock-cslb-footer-menu idblock-cslb-footer classblock block-menu navigation menu--footer>              h2 classvisually-hidden idblock-cslb-footer-menu>Footer menu/h2>                  ul classmenu>                  li classmenu-item>        a hrefhttps://www.cslbehring.com/ target_blank>CSLB Logo/a>              /li>                li classmenu-item>        a hrefhttps://www.cslbehring.de/en-us/contact-us target_blank>Contact Us/a>              /li>                li classmenu-item>        a hrefhttps://www.csl.com/privacy-policy target_blank>Privacy Policy/a>              /li>                li classmenu-item>        a href/cookie-policy target_self data-drupal-link-system-pathnode/34>Cookie Policy/a>              /li>                li classmenu-item>        a hrefhttps://www.cslbehring.de/en-us/terms-of-use target_blank>Terms of Use/a>              /li>                li classmenu-item>        a hrefhttps://www.cslbehring.de/en-us/our-company target_blank>About CSL Behring/a>              /li>                li classmenu-item>        a hrefhttps://www.cslbehring.de/impressum>IMPRESSUM/a>              /li>      /ul>      /nav>div idblock-intendedforeuropeanaudiences classblock block-block-content block-block-contente295ad0e-68c1-464f-8f8e-7af3b761e8d2>                        div classclearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item>p>The content on this website is intended for European audiences. 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Port 443

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Domain > portraitsofprogress.eu

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Port 80

Port 443